The latest on the coronavirus pandemic and vaccines

By Jessie Yeung, Zamira Rahim, Kareem Khadder and Ed Upright, CNN

Updated 8:15 PM ET, Thu March 4, 2021
19 Posts
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11:27 a.m. ET, March 4, 2021

Ivermectin drug is not effective at treating mild Covid-19, study finds

From CNN’s Jen Christensen

A health worker shows a bottle of Ivermectin in Cali, Colombia, on July 21, 2020.
A health worker shows a bottle of Ivermectin in Cali, Colombia, on July 21, 2020. Luis Robayo/AFP/Getty Images

Ivermectin, a drug normally used to treat parasites including lice and rabies, did not seem to have a significant impact and improve the symptoms of patients with Covid-19, according to new research published Thursday, in the Journal of the American Medical Association.

In January, the National Institutes of Health’s Treatment Guidelines Panel said that there is not enough data to recommend for or against the drug to treat Covid-19 patients. 

Even without studies to demonstrate that it works, a few doctors have heavily promoted the drug. It’s a cheap medication with anti-inflammatory properties and it seemed to stop the virus from replicating in lab studies. But just because it works in the lab, doesn’t mean it will work in real life. Most mainstream physicians have reserved their judgment about it

In this study based in Cali, Colombia, nearly 500 adults with mild disease who had symptoms for 7 days, volunteered to help test the drug. The trial is what’s known as a double-blind randomized control trial, the gold-standard of trials. 

Half the volunteers got the drug for five days, the other half got a placebo, and standard care. Patients were enrolled in the trial between July 2020 and November 2020 and doctors followed up with that through December. 

At the end of the trial, there were a nearly equal number of adverse events (mostly headache) in both groups of volunteers. The patients who got the drug said their symptoms subsided by 10 days. For the group that got the placebo, it was 12 days. Two days was not considered a “significant” improvement. 

“The findings do not support the use of ivermectin for treatment of mild COVID-19,” the study concludes. It adds that larger trials may be needed to better understand if ivermectin provides any other kind of benefit to patients with Covid-19. In this case, the study focused on symptoms and mild disease. 

 

11:03 a.m. ET, March 4, 2021

Slovakia will receive 15,000 AstraZeneca vaccines from France, prime minister says

From CNN's Zahid Mahmood and Pierre Bairin

Slovakia will receive 15,000 doses of the AstraZeneca coronavirus vaccine from France, the Slovak Prime Minister Igor Matovic said.

In a statement posted to Facebook on Thursday, Matovic said France has made a gesture of friendship and European solidarity during this “difficult epidemiological situation.”

“At a time when it is understandably very sensitive for all EU countries to offer their own vaccines elsewhere, even if they may need more somewhere else because of a bad situation, the greater is this gesture and the greater is our thanks to the French government,” Matovic said.

On Feb. 25, Macron was questioned on France’s distribution of vaccines to other European states and said some countries did not order their allocated amount from the EU, resulting in France and other countries receiving more doses – now distributing them back.

“In a way, to order more and to have more doses than the pro rata of their population, we have done so. France did it. So strictly speaking, we have a little more doses than our population, same for Germany, Denmark, several, many, many countries,” Macron said.

10:57 a.m. ET, March 4, 2021

Cuba announces its vaccine candidate is authorized to begin Phase 3 trials

From CNN’s Patrick Oppmann

A technician works with the Soberana 02 Covid-19 vaccine at the Finlay Vaccine Institute in Havana, Cuba, on January 20.
A technician works with the Soberana 02 Covid-19 vaccine at the Finlay Vaccine Institute in Havana, Cuba, on January 20. Yamil Lage/Pool/AP

Cuban scientists announced that the island’s Soberana vaccine candidate had received authorization to begin phase three trials immediately.

A second vaccine Abdala would also begin phase three trials soon, scientists said.

While many developing countries have struggled to import vaccines, Cuba has focused on making their own as a way to raise money and instill national pride in the island’s bio-medical industry. 

Two of the four Cuban vaccines candidates are named Soberana – Spanish for sovereignty. The remaining two are called Abdala, the name of a poem written by Cuban revolutionary icon Jose Marti, and Mambisa, referring to Cuban guerillas who fought a bloody war for freedom against the Spanish.

More than 85,000 Cubans would take part in the two final phases of the trials as the island’s state-run biomedical industry begins larger production of the vaccines. If approved for widescale use, Soberana and Abdala would be the first two vaccines developed in Latin America.

You can read more on Cuba’s vaccine trials here.

9:12 a.m. ET, March 4, 2021

Relaxing Covid-19 guidelines is an "invitation" for virus to spread faster, epidemiologist says

From CNN's Adrienne Vogt

Epidemiologist Michael Osterholm on March 4.
Epidemiologist Michael Osterholm on March 4. CNN

Epidemiologist Michael Osterholm said he is concerned about the spread of Covid-19 variants, especially as states ease restrictions. 

“Expect in the next two to three weeks we're going to see a number of areas in this country, I think, that will follow exactly what we've seen in Europe and the Middle East. We're going to see a surge in cases. And everything that the governors are doing right now to relax all the public health recommendations that we've made are only going to be a major invitation of this virus to spread faster and farther,” said Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota.

Texas and Mississippi governors announced they are lifting mask mandates and fully opening businesses, a move that National Institute of Allergy and Infectious Diseases Director Dr. Anthony Fauci called "inexplicable."

While it is very positive that vaccinations continue at a steady pace, “we are denying the gravity of the situation before us,” particularly concerning the more-transmissible variant first identified in the United Kingdom, Osterholm said on CNN’s “New Day.” 

Osterholm said that the number of people currently vaccinated and those previously infected who have immunity add up to about 35 to 40% of the population protected. 

“For the whole last year — for all the pain, suffering and death and illness — we still are only at about 40%. … So add that together with the following: more infectious, more severe illness, and we're loosening up everything. You put those two together and I think the question is, what is going to happen? None of us can say with certainty other than to say it's not going to be good,” he said. 

9:14 a.m. ET, March 4, 2021

The Czech Republic becomes the second EU country to ask for China's Sinopharm vaccine

From CNN's Tomas Etzler in Prague 

A nurse in Budapest, Hungary, holds a dose of the Covid-19 vaccine developed by China's Sinopharm on February 25.
A nurse in Budapest, Hungary, holds a dose of the Covid-19 vaccine developed by China's Sinopharm on February 25. Attila Kisbenedek/AFP/Getty Images

The Czech Republic has requested doses of China’s Sinopharm coronavirus vaccine, according to a tweet from the Czech president's spokesman Jiri Ovcacek. The nation has now become the second country in the European Union (EU) to request Sinopharm, following Hungary. 

The shot has not been approved by the EU's vaccine regulator, the European Medicines Agency (EMA).

"The Prime Minister asked the President of the Republic to contact the President of the PRC with a request for the delivery of the Chinese vaccine Sinopharm,” Ovcacek said on Twitter.
“The Chinese side decided to immediately accommodate this request," he added.

The announcement came after Czech health minister Jan Blatny said on Wednesday that there was no reason to import unregistered vaccines, because insurance companies could not cover the application of such vaccines. 

President Miloš Zeman's move attracted criticism from the country’s opposition parties who described his action’s as “hazardous" for vaccine confidence.

To undermine a fragile trust of many Czechs in vaccination by using insufficiently verified vaccines is hazardous," opposition leader Marketa Pekarova Adamova said on Wednesday according to Czech media. 

She added: "All vaccines should have equal conditions -- if we demand Pfizer, Johnson&Johnson, AstraZeneca [vaccines] and others approval from EMA, we also have to demand it for Sinopharm or Sputnik [Russia's vaccine]."

President Zeman also said in a televised interview on Sunday that he sent a letter to Russian President Vladimir Putin asking him for delivery of Sputnik V. Putin agreed to help, according to Zeman. 

The Czech Republic has been hit hard by Covid-19, with hospitals in the country's Central-Bohemian and Pardubice districts this declaring a state of “mass disability of persons."

This is where hospitals run out of bed space and suffer staff shortages, meaning the quality of care does not comply to national health and safety standards.

The country has recorded more than 1.2 million Covid-19 infections and over 21,000 deaths since the start of the pandemic.

8:43 a.m. ET, March 4, 2021

Germany will extend interval between vaccine doses "to its maximum"

From CNN's Nadine Schmidt in Berlin and Sarah Dean in London

German Chancellor Angela Merkel in Berlin on March 4.
German Chancellor Angela Merkel in Berlin on March 4. Markus Schreiber/AP

Germany will stretch the interval between administering the first and second doses of Covid-19 vaccines “to its maximum," Chancellor Angela Merkel announced on Wednesday.

She said there will be a 42-day gap for the second dose of the Pfizer/BioNTech shot and a 12-week one for the second shot of the AstraZeneca/Oxford vaccine. 

This will allow us to vaccinate more people faster for the first vaccination. This is also recommended by the STIKO [Germany’s vaccine commission],” Merkel said.

The Chancellor also said that in a bid to speed up the rollout of coronavirus vaccines, Germany will aim to swiftly distribute the shots through its network of family doctors’ practices.  

"At the end of March and the beginning of April, the second strand will be the supply of vaccines to the general practitioners in addition to the vaccination centers, so that there will be even more flexibility in the entire vaccination process,” she announced.

The change to Germany’s dosing strategy comes after real-world data from studies appeared to vindicate the UK's strategy of vaccinating as many high-risk people as possible with a first vaccine dose, and delaying the second shot.

The UK policy is for both Pfizer/BioNTech and AstraZeneca second doses to be administered towards the end of the recommended vaccine dosing schedule of 12 weeks, which has allowed for more than 20 million people to receive a first dose of a vaccine. 

Germany has administered around 4 million first doses and 2 million second doses since beginning its vaccination campaign in January, according to official data.

The country's vaccination authority has also approved the use of AstraZeneca's coronavirus shot on the over-65s, the German health ministry told CNN on Thursday.

“The Standing Commission on Vaccination recommends the AstraZeneca vaccine also for persons over 65 years of age,” Health Minister Jens Spahn said in a statement.
“This is good news for all older people who are waiting to be vaccinated. They can be vaccinated more quickly.”

The statement added that new study data showed that when the interval between the first and second vaccination with the AstraZeneca vaccine is extended to twelve weeks, “it is even more effective.” 

In January this year, Germany’s vaccine commission said AstraZeneca should not be given to people older than 65, citing insufficient data on its effectiveness.

But the policy u-turn comes after data from Public Health England released Monday suggested that a single dose of the AstraZeneca vaccine is highly effective against severe infection and hospitalization among elderly populations.

8:32 a.m. ET, March 4, 2021

Worrying Covid resurgence in Eastern Europe, WHO warns, as Hungary goes into lockdown

From CNN's Chloe Adams and Samantha Tapfumaneyi

The World Health Organization (WHO) has warned of a concerning resurgence in coronavirus cases in central and eastern parts of Europe.

“New cases are also on the rise in several western European countries where rates were already high,” Dr. Hans Kluge, WHO regional director for Europe, said during a Thursday news conference.

The continued strain on our hospitals and health workers is being met with acts of medical solidarity between European neighbors. Nonetheless, over a year into the pandemic, our health systems should not be in this situation,” he added

During the WHO news conference, it was also revealed that recent data around the Pfizer/BioNTech and AstraZeneca vaccines have been promising and could lead to further recommendations on dosing intervals.

“The recent data on the Pfizer and AstraZeneca vaccines are encouraging, and I think this will lead us to the review of the earlier recommendations being made,” said Dr. Siddhartha Datta, WHO Europe’s program manager for vaccine preventable disease and immunization. 

A total of 45 countries have started vaccinations in the European region. So far, 1.9% of the population in 40 countries and 24.5% of health workers in 20 countries have received both doses of a vaccine. 

Meanwhile, Hungary will enter another lockdown on March 8 as Covid-19 cases spike across the eastern European country, government spokesman Zoltan Kovacs tweeted on Thursday. 

As part of the lockdown, most shops will be closed and schools will shift to remote learning. The government will also extend state income support to sectors that have to close down from March 8 until March 22.

Kovacs spoke to CNN’s Becky Anderson on Tuesday and warned that the third wave of Covid-19 pandemic would be the hardest one.

The country of around 9.7 million people has reported a total of more than 446,000 Covid-19 cases and around 15,400 deaths, according to the Johns Hopkins University tally.

8:05 a.m. ET, March 4, 2021

Iraq prepares for the visit of Pope Francis

From CNN's Aqeel Najim, Mohammed Tawfeeq in Baghdad and Hamdi Alkhshali

Health workers operate a mobile Covid-19 testing unit at Shorja market in Baghdad, Iraq, on February 22.
Health workers operate a mobile Covid-19 testing unit at Shorja market in Baghdad, Iraq, on February 22. Ahmad Al-Rubaye/AFP/Getty Images

Pope Francis is set to begin his first papal visit to Iraq on Friday, and is scheduled to be in the country for three days. 

The Iraqi government said there will be a 24-hour lockdown for his visit. Last month, it announced a series of restrictive measures, "in light of the increasing number of infections among citizens," to contain the spread of coronavirus." Those measures are scheduled to run through March 8.

Read more on the Pope's visit to Iraq here:

Iraq's Ministry of Health reported 5,043 new confirmed coronavirus cases and 24 fatalities on Thursday, bringing the country's total infections to 713,994 and death toll to 13,507 since the pandemic began.

Additionally, to help fight Covid-19, the Kurdistan region’s borders, in line with other Iraqi provinces, will be closed from Thursday March 4 to Saturday March 6, except for the movement of government delegations, diplomats, coalition forces, and United Nations agencies and organizations.

7:49 a.m. ET, March 4, 2021

Relaxing Covid-19 restrictions in US now is "inexplicable," says Fauci

From CNN's Madeline Holcombe

People visit Pearl Brewery in San Antonio, Texas, on March 3.
People visit Pearl Brewery in San Antonio, Texas, on March 3. Eric Gay/AP

While tens of thousands of Americans are infected with the coronavirus each day and more research suggests variants threaten another surge, some US state leaders are loosening Covid-19 restrictions against the recommendations of health experts.

The decision to rollback measures is "inexplicable," said Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases.

"I understand the need to want to get back to normality, but you're only going to set yourself back if you just completely push aside the public health guidelines -- particularly when we're dealing with anywhere from 55 to 70,000 infections per day in the United States," Fauci told CNN's Erin Burnett.

The governors of Texas and Mississippi said Tuesday they were lifting mandates and allowing businesses to operate at full capacity, announcements that came in the midst of health experts warning that the spread of more transmissible variants risks sending infection rates soaring once again.

Read more here: