The missiles targeting Homs were intercepted and did not cause damage, according to a reporter on Syrian state TV in Homs.
General Joseph Dunford, chairman of the Joint Chiefs of Staff, told reporters tonight that this particular round of airstrikes are over.
"This wave of air strikes is over and that is why we're out here speaking to you now," he said.
However, defense officials made clear tonight in the Pentagon briefing that this is a sustained campaign, and strikes will officially end when the Syrian regime ceases its chemical weapons use.
Defense Secretary James Mattis said the selected targets specifically targeted the Syrian regime's chemical weapons program.
He said that, as of now, there are no reports of losses to the United States.
General Joseph Dunford, chairman of the Joint Chiefs of Staff, said the strikes launched at 9 p.m. ET tonight struck targets associated with the Syrian regime's chemical weapons program.
Here are the three sites he listed:
- A scientific research center located in Damascus.
- A chemical weapons storage facility, which is located west of Homs, Syria.
- The third target, which was in the vicinity of the second target, contained a chemical weapons equipment storage facility and an important command post.
US Defense Secretary James Mattis is speaking at the Pentagon an hour after President Trump announced the start of precision strikes on Syria.
He said that President Trump directed the US military to conduct the operations with the goal of destroying the Syrian regime chemical weapons research and development and production capability.
He added: "Clearly the Assad regime did not get the message last year. This time our allies and we have struck harder. Together we have sent a clear message to Assad and his murderous lieutenants that they should not perpetrate another chemical weapons attack for which they will be held accountable."
Syrian state-run TV says there are reports of aggression targeting the research center in the Barzeh area of the city of Damascus
Syrian air defenses have also hit 13 missiles in Al Kiswah in the suburbs of Damascus, the state TV also reports.
Two US officials said attacks could continue beyond tonight, with a senior administration official saying “this isn't over."
A US official said a big concern is how much more sophisticated Russia’s capabilities are now compared to last year. The source says they are "significantly enhanced" in terms of anti-strike and anti-aircraft capabilities.
Part of the calculation this week has also been gaming out how Russia will respond either in the region or around the world.
“We are watching what Russians do in the next 24 hours,” the official said.
There will be intelligence collection to see what Russians are up to in the wake of the strikes, such as turning on their systems or talking about retaliating.
CNN's Nick Paton Walsh reports that witnesses say they are hearing explosions in Damascus, Syria, and that they began while President Trump was still addressing the nation.