The Build Back Better bill is expected to undergo major revisions in the Senate as Democrats who have expressed concerns over aspects of the package are likely to demand significant changes.
That would then require the House to vote again — on a final version of the legislation — in the coming weeks before it goes to President Biden's desk.
Senate Democrats need all 50 members of their caucus to support the bill in order to pass it under a budget process they are using to advance the measure without GOP votes known as reconciliation. That makes the task for Democrats particularly difficult since it means there can be no defections and passage will require total unity.
In an early sign of the impending efforts to change the bill, Sen. Bernie Sanders of Vermont, an independent who caucuses with Democrats, said in a statement after the House vote that the Senate will "strengthen" the bill.
"I applaud Democrats in the House of Representatives for uniting to pass the Build Back Better Act. The Senate has an opportunity to make this a truly historic piece of legislation. We will listen to the demands of the American people and strengthen the bill," Sanders tweeted.
Senate Majority Leader Chuck Schumer said in a statement after the House vote that the Senate "will act as quickly as possible" to take up the legislation.
House Speaker Nancy Pelosi downplayed the potential for significant changes to the legislation in the Senate.
"Ninety-some percent of the bill was written together, House, Senate, White House. There were some differences at the end, and we'll deal with those as we go forward," Pelosi said at a press conference after the House vote.
"We'll see where we need to, shall we say, reconcile our differences, but at the end of the day we will have a great bill," she said.
Read up on what the Democrats' sweeping social spending plan might include once passed here.