Jerusalem CNN  — 

Separate attacks in the West Bank and Tel Aviv killed three people on Friday after Israel struck Palestinian militant targets in southern Lebanon and Gaza, concluding three days of rising tensions in the region following police raids on the al-Aqsa mosque in Jerusalem.

The Israeli strikes came hours after dozens of rockets were fired from Lebanon into Israeli territory, an attack the Israeli military blamed on Palestinian militants. The barrage from Lebanon was the largest since a 2006 war between the two countries.

Violence continued to spiral Friday when two sisters, aged 16 and 20, with dual British-Israeli citizenship, were killed and their mother was seriously wounded in a shooting attack in the occupied West Bank.

Later in the evening, a group of tourists was hit by a vehicle during an attack in Tel Aviv, described by Israeli authorities as a “terror attack.” An Italian man was killed and seven people were wounded, including three British tourists and an Italian citizen. Of the seven injured, three were still in hospital as of Saturday morning local time, according to the Ichilov Medical Center. The four others had been released.

Israeli Prime Minister Benjamin Netanyahu has “instructed the Israel Police to mobilize all border police units in reserve and the IDF (Israel Defense Forces) to mobilize additional forces in face of terrorist attacks,” according to his office.

The Israeli military said it was on high alert, calling up an unspecified number of reservists amid what it described as “very volatile times.”

The US said it “strongly condemns (the) terrorist attacks in the West Bank and Tel Aviv.”

“The three horrific attacks today, in which three were killed and at least eight others wounded, affected citizens of Israel, Italy and the United Kingdom. The targeting of innocent civilians of any nationality is unconscionable,” State Department deputy spokesperson Vedant Patel said in a statement issued Friday.

“The United States stands with the government an