Director of the Office of Management and Budget nominee Neera Tanden speaks during an event to name President-elect Joe Biden's economic team at the Queen Theater on December 1, 2020 in Wilmington, Delaware.
CNN  — 

President Joe Biden’s nominee to lead the Office of Management and Budget Neera Tanden will carry on with her outreach to senators next week after her confirmation was jeopardized Friday when Democratic Sen. Joe Manchin revealed he would vote against her.

So far, Tanden has met with 35 senators on both sides of the aisle, according to a source involved with the confirmation process. “That outreach, which began moments after she was named, is continuing into next week,” the source said.

The confirmation team has also been speaking with outside interest groups, including Asian American and Pacific Islander (AAPI) organizations, the business community, women business leaders, and labor unions, to drum up support for her nomination, the source said.

Manchin announced Friday he will vote against Tanden, making her confirmation unlikely given Republican resistance to her nomination. The senator’s decision means that unless a Republican senator comes forward to support Tanden’s nomination, it’s unlikely that she will be confirmed for the job, making key GOP votes more important than ever.

Senate Majority Leader Chuck Schumer has a narrow majority in a 50-50 Senate. Because Democrats control the White House, Vice President Kamala Harris can break ties, but without Manchin’s support, Democrats won’t have the votes on their own.

GOP Sen. Mitt Romney’s office won’t say how he will vote on Tanden, and there was no immediate response from Republican Sens. Susan Collins of