Chemicals in plastics damage babies' brains and must be banned immediately, expert group says

Phthalates, human-made chemicals in the plastics we use, are negatively impacting brain development in kids, according to a group of volunteer scientists, health professionals and child advocates.

(CNN)Synthetic chemicals called phthalates are damaging children's brain development and therefore must be immediately banned from consumer products, according to a group of scientists and health professionals from Project TENDR.

Project TENDR, which stands for Targeting Environmental Neuro-Development Risks, is a group of volunteer scientists, health professionals and child advocates working to study and reduce children's exposure to neurotoxic chemicals and pollutants.
"What we want to accomplish is to move the public health community, including regulators, toward this goal of elimination of phthalates," said lead author Stephanie Engel.
    "We have enough evidence right now to be concerned about the impact of these chemicals on a child's risk of attention, learning and behavioral disorders," said Engel, a professor of epidemiology at the University of North Carolina at Chapel Hill Gillings School of Global Public Health.
      "I hope that this paper will act as a wake-up call to understand that early life exposure to this class of chemicals is affecting our children," said toxicologist Linda Birnbaum, former director of the National Institute for Environmental Health Sciences, as well as the National Toxicology Program. She was not involved in the paper.
        "When you have the same kind of findings repeated in multiple populations, done by different investigators using different tools and approaches and you keep coming up with the same finding, I think you can begin to say that the data is pretty clear," Birnbaum said.
        CNN reached out for comment from the trade association American Chemistry Council.
          "While we are encouraged by continuous research efforts into the science and health of phthalates, we are concerned about the over interpretation of studies that have not established a causal link between phthalates and human adverse health effects," said Eileen Conneely, senior director of the chemical products and technology division of ACC.

          'Everywhere chemicals'

          Called "everywhere chemicals" because they are so common, phthalates are added to consumer products to make the plastic more flexible and harder to break.
          Phthalates are found in hundreds of auto, home, food and personal care items: food packaging; detergents; vinyl flooring, clothing, furniture and shower curtains; automotive plastics; lubricating oils and adhesives; rain and stain-resistant products; and scores of products including shampoo, soap, hair spray and nail polish, in which they make fragrances last longer.
          Phthalates must be listed among the ingredients on product labels, unless they are added as a part of the scent. Under current US Food and Drug Administration regulations, phthalates can be simply labeled "fragrance," even though they could be as much as 20% of the product, studies say.
          Phthalates are also in PVC plumbing and building products and items such as medical tubing, garden hoses, and some children's toys. Globally, approximately 8.4 million metric tonnes of phlathates and other plasticizers are consumed annually, according to European Plasticizers, an industry trade association.

          Neurotoxins

          The new call to action, published Thursday in the American Journal of Public Health, focuses specifically on the link between phthalate exposure and long-lasting neurodevelopmental harm in fetuses, infants and children.
          By 2019, more than 30 studies had examined prenatal exposure to different types of phthalates, and long-term studies had been done in 11 different countries or territories around the globe, the report said. Not all of the papers had found consistent results, especially in the area of cognitive development, but the report's authors said that might be due to difference in study designs and children's ages.
          The report said the strongest associations have been found with hyperactivity, aggression, defiance, emotional reactivity, delinquent behaviors and other signs of attention deficit hyperactivity disorder, or ADHD, after exposure to phthalates.
          One study, for example, found children of mothers with the highest levels of phthalates in their urine during their second trimester had almost three times the odds of being diagnosed with ADHD as children with mothers who had much lower levels.
          A link between phthalate exposure and poorer working memory and intelligence has also been found. One study discovered children who were exposed to higher levels of phthalates in utero had an IQ level that was seven points lower than children with less exposure. The highest-risk kids also had reduced perceptual reasoning and verbal comprehension.
          Conneely of the ACC, however, pointed to recent systematic reviews that pulled together available data on neurobehavioral and cognition effects and "concluded that there was no association between DINP and DIDP and neurobehavioral or cognitive effects."
          Diisononyl phthalate (DINP) and di-isodecyl phthalate (DIDP) are two of the many types of chemicals in the family of phthalates.
          In addition, Conneely said, "data from the US Centers for Disease Control and Prevention clearly show exposure levels to phthalates are well below the levels determined by US Environmental Protection Agency (EPA) and other regulatory bodies to be safe."
          It's true that "federal regulation of phthalates in the United States has been minimal with several exceptions, including restrictions on 8 phthalates in children's toys and childcare articles," the study said.
          However, the study continued, "we strongly urge both federal and state agencies to move rapidly to eliminate phthalate use," adding that "states should not wait for the federal government to act, as state action can galvanize federal regulation."
          In response to CNN's request, an EPA spokesperson provided the following comment.
          "As the Biden-Harris Administration works to advance EPA's mission of protecting human health and the environment, the agency is committed to ensuring the safety of chemicals used by all Americans.
          "The agency is actively working to ensure all (Toxic Substances Control Act) chemical risk evaluations, including the ongoing evaluations for seven phthalates, follow the science and the law and that any resulting risk management actions protect human health, particularly the health of more vulnerable groups like children and workers, and the environment."

          Timing of exposure

          Unlike toxic metals such as lead, arsenic, cadmium and mercury, phthalates are more rapidly metabolized and typically leave the body once exposure is removed.
          "They have much shorter biological half lives than, say, the heavy metals, which can hang around for decades," said David Bellinger, a professor of neurology and psychology at Boston Children's Hospital and a member of Project TENDR who was not involved in the new paper.
          The problem, Bellinger added, is that once the baby's developing brain is impacted by the chemical in utero, the damage has been done.
          "The brain might be exposed at just the wrong time," Bellinger said. "That's the concern."
          Critics argue that studies showing distinct neurodevelopmental harm have only been done in animals, while studies on young children focus on behavioral impacts, such as increases in behavioral disorders and attention and learning deficits.
          "There will never be gold-standard randomized clinical trials," said Birnbaum, because science would never deliberately expose a child to such chemicals. That's the whole issue with environmental exposures."

          Elimination is the goal

          The paper called for the elimination of the entire class of phthalates from products that lead to the exposure of pregnant women, women of reproductive age, infants and children.
          Banning them one-by-one won't adequately lessen the threat, Engel said.
          "We're exposed to multiple phthalates, and that mixture can come within a single product, but also across multiple products that people are exposed to in a day," Engel said. "The reality is that we need to think of phthalates as a class because that's how people are exposed to them."
          Another reason that the entire class of phthalates should be regulated, BIrnbaum said, is to keep manufacturers from replacing one "bad actor" with another phthalate that hasn't been as thoroughly studied.
          "This is the whole history of these chemicals," Birnbaum said, "whether you call it 'whack a mole' or 'chemical conveyor belt' or 'unfortunate substitution.' We move from one chemical that we have concerns about to another one which we just haven't studied yet, which often turns out to be just as problematic.
          "We can't continue to test these things one at a time," Birnbaum continued. "I could make an argument that if one chemical can be substituted for another without changing the process, then why would you think the biology would be different?"
          Critics point to the expense of removing an entire class of chemicals from the marketplace.
          "Cost is always the counter argument to change," Engel told CNN. "But the current system has costs, too. It's just that we've become accustomed to paying them. Right now families, health care, school systems are shouldering the costs of a lack of health protective regulation for children."
          Engel also argues that elimination of the entire class of chemicals is possible "because manufacturers are already showing us that it's feasible," and points to a number of actions already taken by the marketplace. Apple, the paper said, has removed "phthalates as a class from almost all products," while other companies like CVS and The Home Depot have reduced the use of phthalates in beauty, personal care products, household products and vinyl flooring.