(CNN)If you're lonely, your brain might value Ellen DeGeneres, Mark Zuckerberg, your coworker and your best friend all the same — even though you clearly know some of them better than others.
When we're lonely, close friends, colleagues and celebrities all might seem the same to our brains
Loneliness — a perceived gap or disconnection between yourself and others — might affect how your brain perceives the people or relationships in your life, according to a study published Monday in the journal J. Neurosci.
Here's how that perception might happen.
Social connection is critical to our well-being, according to studies showing that having good relationships with friends and family boosts our mental and physical health. The more socially connected a person is, the higher his or her likelihood of reduced blood pressure, weight and stress.
On the flip side, social isolation has been linked with a higher risk of early death and a higher risk of diseases such as heart disease and cancer.
Although feeling close to others is so crucial, how the brain reflects that closeness has remained mostly obscure, according to the study. Filling this research gap was critical, the authors contended, as it might reveal mechanisms doctors and lonely patients could act upon to improve interpersonal connection and thus health.
With increased reports of loneliness around the world due to sheltering in place and social distancing, the impact of loneliness on people's health has researchers concerned.
Previous research has emphasized the strength of "weak ties" — those maintained by regular interactions with acquaintances with whom we work or attend school. Acquaintances might have an important role in well-being and social support.
"Our findings suggest that understanding how the brain represents weak ties may yield important insight into how loneliness links to negative outcomes," the study said.
Some recent articles on social distancing and working from home have cited the obscure importance and current absence of weak ties as reason for worry about the potential effects of both shifts on our mental health.
"We're missing out on a lot of that," said first author Andrea Courtney, a postdoctoral research fellow in psychology at Stanford University in California. "So that could be a part of why we're seeing increases in loneliness."
In the new study, the authors conducted brain scans on the medial prefrontal cortex (MPFC), the region of the brain associated with self-representation — the image a subject has of himself based on his own interpretation.
The purpose was to see how people organized representations of others based on how connected others were to participants' own identities, and whether loneliness affected that structure.
The MPFC is known to activate when thinking about oneself, but it has exhibited similar activation when thinking about people one is close with.
If the MPFC represented social connections, there were two possible ways, the researchers hypothesized: The MPFC would keep a map of social circles, with people organized by closeness; or interpersonal closeness would affect their own self-representations, with closer peers more similarly represented to themselves.
If the MPFC organized self- and other-representations in either of these ways, the following question was whether loneliness might be linked to alterations in that structure.
The scans showed that the MPFC maintained a network of social circles, based on closeness. The gap between oneself and others that lonely people often perceive was reflected by altered activity patterns in the brains of lonelier participants.
"Other people have looked at loneliness in the brain, but for the most part it's been how loneliness affects responses to other things" — for example, altered reward or threat responses in people who are lonely, Courtney said.
"We're really trying to get at what the mechanism is behind loneliness and really trying to tease apart this perceived self-other gap, which we think can not only help us understand neuroscience, but also helps us to understand maybe what loneliness is and where it's coming from."
Study participants included 43 college students and community members between ages 18 and 47 and with reported normal neurological histories.
Before the brain scans, they wrote the names of five people with whom they had the "closest, deepest, most involved and most intimate relationships" and five acquaintances, such as classmates, colleagues or neighbors, ranked in the order in which they felt closest to them.
Responses to the University of California, Los Angeles, Loneliness Scale determined how much participants felt they lacked companionship, had no one to turn to or that people were around them but not with them.
In the MRI experiments, the names and celebrity names were used to elicit brain activation associated with thinking about people close to them and those who were acquaintances.
Afterward, participants scaled their closeness to each target. People close to them were rated closer than acquaintances, who were determined closer than celebrities. The similarity of the people within each group was likewise rated.
Thinking about someone from each category corresponded with a different activity pattern in the medial prefrontal cortex: one each for the self; close others and acquaintances; and celebrities.
British evolutionary psychologist Robin Dunbar has "this idea of social circles in which, basically, there is a maximum number of people that you can maintain in your social circle due to the cognitive demands of interacting with a particular number of people," Courtney said. "There are sort of only so many people that can belong to your close, intimate circles."
The closer the subjects were to the participant, the more the activity pattern resembled the pattern seen when they thought of themselves.
But the patterns differed for lonelier individuals — the perceived similarity between themselves and others was reduced. Their brains also grouped all categories of people and those within them as similar — regardless of the fact that they actually listed different people as being close or acquaintances, and regardless of the person they thought about during the scan.
"You would expect there to be this differentiation between close others and acquaintances, but actually you're seeing less of that for people who are lonely," Courtney said.
"This blurring of social circles with loneliness was even observed in the similarity between close others and celebrities," the study said.
Though the participants' brains represented themselves separately from others, that distance was bridged by their brains' perceptions of their closest friends as the most similar to themselves.
"The social brain appears to map our personal ties, and alterations in this map may help explain why lonely individuals endorse statements such as 'people are around me but not with me,'" the study said.
That feeling "really gets at the idea that there's a di