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Iraqis protest against Baghdad and Iran
04:07 - Source: CNN
CNN  — 

At least 12 demonstrators were killed and 22 others wounded Friday when gunmen in several vehicles opened fire on a protest site in central Baghdad, medical sources and activists told CNN, marking one of the most violent days in the Iraqi capital for weeks.

As thousands of anti-government demonstrators rallied in Baghdad’s Tahrir Square – the epicenter of the protest movement – the gunmen seized a nearby parking garage that is used by activists.

The gunmen have not yet been identified.

An ambulance arrives in Tahrir Square after gunmen opened fire on anti-government protesters.

Hundreds of members of pro-government militias have descended on Tahrir Square in a show of force over recent days, raising fears over further unrest, several activists told CNN.

During his weekly Friday sermon, Iraq’s top Shiite cleric warned against meddling, saying that the country’s new premier must be chosen “without any foreign interference.” The clock is ticking for lawmakers to replace Prime Minister Adil Abdul Mahdi, who announced his resignation last week, calling on Iraq’s government to “preserve the blood of its people” and “avoid slipping into a cycle of violence, chaos and devastation.”

News of Abdul Mahdi’s departure was greeted in Baghdad’s Tahrir Square with fireworks.

Grand Ayatollah Ali al-Sistani has previously condemned the killing of unarmed protesters, as well as the government’s failure to handle the demonstrations, sparked over endemic corruption, high unemployment, inadequate public services and Iran’s interference in the country. Protesters blame Iran for being complicit in the Iraqi government’s failures, and now its crackdown.

Al-Sistani’s remarks came on the same day that the United States imposed sanctions on four Iraqis, including “three leaders of Iran-backed militias” over corruption and human rights abuses. According to a statement released by the Treasury Department, the militias were behind the killing of dozens of peaceful protesters.

Demonstrators rally in Baghdad's Tahrir Square.

“Iraqis have played a step and bloody price” because of the Iranian regime’s involvement in the country, assistant secretary of state David Schenker said.

Schenker noted that Qassem Suleimani, leader of Iran’s elite Quds Force, has recently been in Iraq in part “to determine the next political leader of Iraq.”

“It is not normal,” Schenker said. “This is unorthodox … a huge violation of Iraqi sovereignty.”

Some 432 people have been killed since anti-goverment demonstrations began in Iraq on October 1, according to a source with the Independent High Commission for Human Rights of Iraq. Another 19,136 people have been injured in the demonstrations, the Commission has said.

Activists are calling for the government to step down and hold early elections under direct supervision of the United Nations, in response to the deadly crackdown.

CNN’s Nicole Gaouette and Kylie Atwood contributed to this report.