(CNN)Samantha Bee is taking on anti-vaxxers.
The "Full Frontal" host used the set of Netflix's "Riverdale" as a backdrop for her message Wednesday, renaming it "Full Fronterdale."
She kicked off the segment by interviewing Ethan Lindenberger, the Ohio teen who made headlines after he went against his parents' wishes when he turned 18 and got vaccinated.
Bee transformed into a cheerleader who had been convinced by her mom that getting vaccinated is wrong.
When one of the show's characters, Archie Andrews [KJ Apa], approaches Bee with a Band-Aid on his arm, she immediately asks, "Oh my god, Archie, are you hurt?"