A picture taken early on January 21, 2019 shows Syrian air defence batteries responding to what the Syrian state media said were Israeli missiles targeting Damascus. - Israel struck what it said were Iranian targets in Syria today in response to rocket fire it blamed on Iran, sparking concerns of an escalation after a monitor reported 11 fighters killed. Israel openly claimed responsibility for the strikes against facilities it said belonged to the Iranian Revolutionary Guards' Quds Force, continuing its recent practice of speaking more openly about such raids. (Photo by STR / AFP)        (Photo credit should read STR/AFP/Getty Images)
STR/AFP/Getty Images
A picture taken early on January 21, 2019 shows Syrian air defence batteries responding to what the Syrian state media said were Israeli missiles targeting Damascus. - Israel struck what it said were Iranian targets in Syria today in response to rocket fire it blamed on Iran, sparking concerns of an escalation after a monitor reported 11 fighters killed. Israel openly claimed responsibility for the strikes against facilities it said belonged to the Iranian Revolutionary Guards' Quds Force, continuing its recent practice of speaking more openly about such raids. (Photo by STR / AFP) (Photo credit should read STR/AFP/Getty Images)
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Israel carried out a series of airstrikes early Monday against Iranian targets in Syria, the Israeli military said, in response to an Iranian missile fired at the Golan Heights, capping off a volatile 24 hours between the two regional enemies with the possibility of more fighting ahead.

The Israel Defense Forces (IDF) struck Iranian targets in and around Damascus, including the city’s international airport, IDF Spokesman Lt. Col. Jonathan Conricus said. The overnight strikes targeted munitions depots, intelligence sites, a training camp and more, Conricus said.

The IDF also struck Iranian warehouses at the Damascus International Airport, Conricus said, noting that Israel observed secondary explosions, indicating that weapons had been hit.

Israel also attacked Syrian anti-aircraft batteries when those batteries fired dozens of missiles at Israeli aircraft carrying out the strikes, Conricus said. Israel relayed a message to Syria that the military was only targeting Iranian forces and warned Syria not to fire at Israeli jets.

The wide-ranging strikes were in response to a medium range surface-to-surface missile fired toward the Israeli-occupied Golan Heights on Sunday afternoon. The missile was made by Iran and launched by Iranian forces, Conricus said, adding that it’s the first time a missile with such a payload has been fired by Iranian forces at Israel.

The missile was fired from an area near Damascus, Conricus said, which is approximately 50 kilometers from the Golan Heights. Russia had assured Israel that no Iranian forces would be this close to Israel, according to Conricus.

Missiles flying into the sky near international airport, in Damascus, Syria.
SANA/AP
Missiles flying into the sky near international airport, in Damascus, Syria.

On Monday, Netanyahu promised Israel would continue to act against Iran’s presence in Syria.

“We will not ignore such acts of aggression as Iran attempts to entrench itself militarily in Syria and given explicit statements by Iran that it intends to destroy Israel, as the commander of the Iranian air force has just said,” said Netanyahu, speaking at the opening of an airport in southern Israel. “We are acting against Iran and against the Syrian forces that abet the Iranian aggression. Whoever tries to hurt us – we hurt them. Whoever threatens to destroy us will bear the full responsibility.”

Russian state media agency RIA-Novosti reported four Syrian soldiers were killed and another six wounded in the Israeli strikes, citing Russia’s defense control center.

The London-based Syrian Observatory for Human Rights (SOHR) said 11 were killed in the strike, including 2 Syrian nationals. The SOHR described the Israeli attack as the “most intense and violent attack against the regime forces and their allies in terms of casualties since May 2018,” when Israel carried out a large-scale attack on Iranian targets in Syria following dozens of rockets launched from Syria toward Israel. Israel accused Iran of firing the rockets.

But Iran’s state-run FARS news agency denied that any casualties had taken place and reported that Syrian air defenses managed to intercept seven Israeli missiles fired into Syrian territory.

Syrian air defenses destroyed more than 30 cruise missiles and guided air bombs in the course of repelling the attack, Russian state media reported.

The head of Iran’s air force, Brig. Gen. Aziz Nasirzadeh, said Iran was growing impatient to fight Israel and promised to destroy the “Zionist regime.”

“The young people in the air force are fully ready and impatient to confront the Zionist regime and eliminate it from the Earth,” said Nasirzadeh, quoted by the Young Journalists Club, a website supervised by state television.

Israel’s military remains on elevated alert in the north and the ski area in the Golan Heights has been closed, but there are no other restrictions on civilian movement, Conricus said.

The IDF hinted that military activity could continue, saying it was “prepared for all scenarios and will continue operating as needed to defend Israeli civilians.”

CNN’s Joshua Berlinger and Mary Ilyushina contributed to this report