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(CNN) —  

A Louisiana congregation was in mourning after five children riding in a church van bound for Disney World were killed in a fiery Florida crash.

Bryan Ross, affiliated with Avoyelles House of Mercy, said that the group, which included the pastor’s wife, had set off from Marksville on Thursday morning.

The other two killed in Thursday afternoon’s collision were men driving semi-trucks, Florida Highway Patrol Lt. Patrick Riordan told reporters at a news conference.

The multivehicle crash happened on Interstate 75 near Gainesville, according to authorities.

Riordan said preliminary information indicates that a tractor trailer and a car traveling northbound on I-75 collided with each other and went through a guardrail, entering the southbound lanes. Those two vehicles then struck the large passenger van and another semi-truck. A fifth vehicle struck some of the occupants or debris in the roadway, Riordan said.

Three girls and two boys in the van died. The condition of the pastor’s wife was unknown.

“It’s just a tragedy,” Ross told CNN.

A photo posted by the Alachua County Fire Rescue showed a tractor-trailer in flames with a vehicle under its left side.

As many as eight others were hurt, the lieutenant said. Some of the patients transported from the scene have critical injuries, according to the fire and medical service.

A homicide investigation is underway, Riordan said.

The FHP will issue a detailed statement on the accident after the families of the victims have been notified.

Clarification: This story has been updated to fix the spelling of Disney World.

CNN’s Steve Almasy contributed to this report.