BRISTOL, ENGLAND - JANUARY 07:  In this photo-illustration a man holds a burger purchased from a fast food outlet on January 7, 2013 in Bristol, England.  A government-backed TV advert - made by Aardman, the creators of Wallace and Gromit - to promote healthy eating in England, is to be shown for the first time later today. England has one of the highest rates of obesity in Europe - costing the NHS 5 billion GDP each year - with currently over 60 percent of adults and a third of 10 and 11 year olds thought to be overweight or obese.  (Photo by Matt Cardy/Getty Images)
BRISTOL, ENGLAND - JANUARY 07: In this photo-illustration a man holds a burger purchased from a fast food outlet on January 7, 2013 in Bristol, England. A government-backed TV advert - made by Aardman, the creators of Wallace and Gromit - to promote healthy eating in England, is to be shown for the first time later today. England has one of the highest rates of obesity in Europe - costing the NHS 5 billion GDP each year - with currently over 60 percent of adults and a third of 10 and 11 year olds thought to be overweight or obese. (Photo by Matt Cardy/Getty Images)
PHOTO: Matt Cardy/Getty Images
Now playing
01:19
What goes into the fast food meat you eat?
PHOTO: @Virgin_Orbit
Now playing
01:03
Watch this rocket launch from the wing of a jumbo jet
WASHINGTON, DC - JUNE 22: Facebook
WASHINGTON, DC - JUNE 22: Facebook's Chief Operating Officer Sheryl Sandberg speaks with AEI president Arthur C. Brooks during a public conversation on Facebook's work on 'breakthrough innovations that seek to open up the world' at The American Enterprise Institute for Public Policy Research on June 22, 2016 in Washington, DC. (Photo by Allison Shelley/Getty Images)
PHOTO: Allison Shelley/Getty Images North America/Getty Images
Now playing
01:23
Hear Sandberg downplay Facebook's role in the Capitol riots
Passengers look out at American Airlines flight 718, a Boeing 737 Max, parked at its gate at Miami International Airport as people load for the flight to New York on December 29, 2020 in Miami, Florida. The Boeing 737 Max flew its first commercial flight since the aircraft was allowed to return to service nearly two years after being grounded worldwide following a pair of separate crashes. (Photo by Joe Raedle/Getty Images)
Passengers look out at American Airlines flight 718, a Boeing 737 Max, parked at its gate at Miami International Airport as people load for the flight to New York on December 29, 2020 in Miami, Florida. The Boeing 737 Max flew its first commercial flight since the aircraft was allowed to return to service nearly two years after being grounded worldwide following a pair of separate crashes. (Photo by Joe Raedle/Getty Images)
PHOTO: Joe Raedle/Getty Images
Now playing
03:15
Airlines & TSA boost security ahead of Inauguration
Philanthropist Chief Executive Officer of Las Vegas Sands Sheldon Adelson listens to US President Donald Trump address to the Israeli American Council National Summit 2019 at the Diplomat Beach Resort in Hollywood, Florida on December 7, 2019. (Photo by MANDEL NGAN / AFP) (Photo by MANDEL NGAN/AFP via Getty Images)
Philanthropist Chief Executive Officer of Las Vegas Sands Sheldon Adelson listens to US President Donald Trump address to the Israeli American Council National Summit 2019 at the Diplomat Beach Resort in Hollywood, Florida on December 7, 2019. (Photo by MANDEL NGAN / AFP) (Photo by MANDEL NGAN/AFP via Getty Images)
PHOTO: Mandel Ngan/AFP/Getty Images
Now playing
03:14
Major GOP donor and casino magnate Sheldon Adelson dies
Democratic presidential candidate and former US Vice President Joe Biden speaks on the state of the US economy on September 4, 2020, in Wilmington, Delaware. (Photo by JIM WATSON / AFP) (Photo by JIM WATSON/AFP via Getty Images)
Democratic presidential candidate and former US Vice President Joe Biden speaks on the state of the US economy on September 4, 2020, in Wilmington, Delaware. (Photo by JIM WATSON / AFP) (Photo by JIM WATSON/AFP via Getty Images)
PHOTO: JIM WATSON/AFP/Getty Images
Now playing
02:02
Why Wall Street is hopeful about Biden despite economic challenges
Now playing
05:39
Ben & Jerry's calls for Trump's removal
This illustration picture shows the social media website from Parler displayed on a computer screen in Arlington, Virginia on July 2, 2020. - Amid rising turmoil in social media, recently formed social network Parler is gaining with prominent political conservatives who claim their voices are being silenced by Silicon Valley giants. Parler, founded in Nevada in 2018, bills itself as an alternative to "ideological suppression" at other social networks. (Photo by Olivier Douliery/AFP/Getty Images)
This illustration picture shows the social media website from Parler displayed on a computer screen in Arlington, Virginia on July 2, 2020. - Amid rising turmoil in social media, recently formed social network Parler is gaining with prominent political conservatives who claim their voices are being silenced by Silicon Valley giants. Parler, founded in Nevada in 2018, bills itself as an alternative to "ideological suppression" at other social networks. (Photo by Olivier Douliery/AFP/Getty Images)
PHOTO: Olivier Douliery/AFP/Getty Images
Now playing
03:49
Parler sues Amazon in response to being deplatformed
Panasonic
Panasonic's Augmented Reality Heads-up Display
PHOTO: Panasonic USA
Now playing
01:06
This tech gives drivers directions on the road in front of them
PHOTO: Wimkin
Now playing
03:18
The online warning signs of the violent Capitol siege
PHOTO: Twitter
Now playing
02:39
Twitter permanently suspends Donald Trump from platform
PHOTO: CNN
Now playing
03:56
'What are we supposed to do?': Rioter speaks to CNN reporter
President Donald Trump arrives to speak at a rally protesting the electoral college certification of Joe Biden as President, Wednesday, Jan. 6, 2021, in Washington. (AP Photo/Evan Vucci)
President Donald Trump arrives to speak at a rally protesting the electoral college certification of Joe Biden as President, Wednesday, Jan. 6, 2021, in Washington. (AP Photo/Evan Vucci)
PHOTO: Evan Vucci/AP
Now playing
01:38
Facebook blocks Trump through end of presidency
PHOTO: CNN
Now playing
02:56
CNN speaks to Trump supporters about Trump's election lies
NEW YORK, NY - JUNE 3: The Google logo adorns the outside of their NYC office Google Building 8510 at 85 10th Ave on June 3, 2019 in New York City. Shares of Google parent company Alphabet were down over six percent on Monday, following news reports that the U.S. Department of Justice is preparing to launch an anti-trust investigation aimed at Google. (Photo by Drew Angerer/Getty Images)
NEW YORK, NY - JUNE 3: The Google logo adorns the outside of their NYC office Google Building 8510 at 85 10th Ave on June 3, 2019 in New York City. Shares of Google parent company Alphabet were down over six percent on Monday, following news reports that the U.S. Department of Justice is preparing to launch an anti-trust investigation aimed at Google. (Photo by Drew Angerer/Getty Images)
PHOTO: Drew Angerer/Getty Images North America/Getty Images
Now playing
03:25
Google employee on unionizing: Google can't fire us all
FILE - In this undated file photo issued by the University of Oxford, a researcher in a laboratory at the Jenner Institute in Oxford, England, works on the coronavirus vaccine developed by AstraZeneca and Oxford University. Britain on Wednesday, Dec. 30, authorized use of a second COVID-19 vaccine, becoming the first country to greenlight an easy-to-handle shot that its developers hope will become the "vaccine for the world." The Department of Health said it had accepted a recommendation from the Medicines and Healthcare Products Regulatory Agency to authorize the vaccine developed by Oxford University and U.K.-based drugmaker AstraZeneca.  (John Cairns/University of Oxford via AP, File)
FILE - In this undated file photo issued by the University of Oxford, a researcher in a laboratory at the Jenner Institute in Oxford, England, works on the coronavirus vaccine developed by AstraZeneca and Oxford University. Britain on Wednesday, Dec. 30, authorized use of a second COVID-19 vaccine, becoming the first country to greenlight an easy-to-handle shot that its developers hope will become the "vaccine for the world." The Department of Health said it had accepted a recommendation from the Medicines and Healthcare Products Regulatory Agency to authorize the vaccine developed by Oxford University and U.K.-based drugmaker AstraZeneca. (John Cairns/University of Oxford via AP, File)
PHOTO: John Cairns/University of Oxford/AP
Now playing
02:36
AstraZeneca vaccine provides 'logistical convenience'

Story highlights

New report looks at antibiotic use in 25 US burger chain restaurants

Shake Shack and BurgerFi were the only two places to receive A grades

(CNN) —  

Twenty-five of the top US burger chains were graded on their antibiotic policies in a collaborative report released Wednesday. Only two chains received As, Shake Shack and BurgerFi; the other 23 got a D minus or F.

“It’s really exciting to hone in on beef because we know that Americans love burgers. It’s one of the most favorite foods in our country, and taking a closer look at what is and isn’t happening when it comes to responsible antibiotic use in that sector seemed particularly important,” said Lena Brook, lead researcher of the report and interim director of the food and agriculture program at the nonprofit Natural Resources Defense Council, one of the organizations involved in the research.

Brook said that after seeing positive changes in poultry used by fast food restaurants from the group’s past reports, it made the decision to focus on beef and burger chains for its fourth annual report.

Fast food restaurants were ranked by total US sales to get the top 25. The report grades the restaurants in three areas, according to Brook. The first is whether these companies are making pledges or policies to end the routine use of antibiotics, the second is how the companies are implementing the policies, and the third is verifying whether the claims being made by the companies are true.

The report identified Shake Shack and BurgerFi as the only two chains to serve antibiotic-free beef.

“What’s interesting about that is they also happen to be what I think of to be these younger upstarts that are disrupting the normal kind of operational model that burger chains have use for decades now, and customers are really responding to that,” Brook said. “They are being rewarded for the good food that they are serving and the good practices that stand behind that food, and serving responsibly raised beef is a part of that new business model.”

Smaller burger companies such as Elevation Burger, which has 50 locations in the United States and abroad and serves beef raised without antibiotics, according to the report authors, received honorable mentions. Brook said this suggests that there is an emerging type of chain that is adhering to good antibiotic use policies.

Wendy’s was given a D minus for a policy that the authors described as “while far from comprehensive … a positive step forward.” According to the company’s website, Wendy’s will get about 15% of its beef from producers that have committed to a 20% reduction in antibiotics used in their livestock and whose cattle’s antibiotic use can be tracked and reduced.

“As we go forward, we have a goal of eliminating routine antibiotic use in our beef and pork supply, while protecting the need for targeted, therapeutic use of an antibiotic in the limited cases where a sick animal needs to be treated individually, or in the unlikely case that animals have been exposed to an illness and treatment with an antibiotic is necessary to prevent a disease outbreak,” Liliana Esposito, chief communications officer for The Wendy’s Co., wrote in a blog post.

The other 22 chains, including places such as McDonalds, received F grades.

“Preserving the effectiveness of antibiotics for future generations is highly important to McDonald’s,” company spokeswoman Lauren Altmin wrote in an email. “In 2016, McDonald’s fully implemented its pledge to no longer serve chicken treated with antibiotics important to human medicine in its US restaurants, which led to the 2018 implementation of an antibiotic use policy for broiler chicken in markets around the globe. McDonald’s is currently finalizing a global antibiotics policy for beef, to begin roll out before the end of 2018.”

Only seven of the companies that were sent surveys responded to the researchers. But not returning a survey did not lead to an automatic failing grade, Brook said. Nonresponders were graded on publicly available information about their antibiotic policies while losing points only in the survey submittal category.

The report says that the “overuse of antibiotics in livestock production significantly contributes to the spread of antibiotic resistance.” The World Health Organization, the US Food and Drug Administration and the US Centers for Disease Control and Prevention consider antibiotic resistance a threat to public health.

“Sometimes, antibiotics are used to treat sick animals, and that’s great, we are 100% supporting of that, and they are a really important part of the veterinary tool kit. But unfortunately, oftentimes, they are also given to animals either to promote faster growth or for the so-called disease prevention purpose,” Brook said.

Charlie Arnet, CEO of the nonprofit Center for Food Integrity, agrees that antibiotics must be used responsibly.

“We all want healthy animals and safe food that is sustainably produced. The responsible use of antibiotics helps make that a reality,” he wrote in an email.

Antibiotic-resistant bacteria can be spread to humans in a number of ways, the CDC says. For example, resistant germs can lurk in the gut of an animal when it is killed, contaminating meat and other products, or animal waste containing resistant germs can be used as fertilizer or for irrigation on produce.

The CDC has reported that every year in the United States, at least 23,000 people die and 2 million get sick with antibiotic-resistant infections. Two of the bacteria that are commonly spread through food, salmonella and campylobacter, make more the 400,000 Americans sick each year.

“In simplest terms, what it means is that once a bacteria are resistant to antibiotics, that means the ability of doctors to treat the infection becomes extremely limited, and so that’s really scary, because it means that infections that were once really easily and commonly treated could actually be fatal, or common medical procedures would no longer be possible because of a risk of infection without antibiotics,” said Brook.

WHO credits the misuse of antibiotics, both in humans and in animals, as “accelerating the process” of antibiotic resistance. In 2015, it released recommendations around animal antibiotic use that included a reduction in medically important antimicrobials in food-producing animals, a restriction in these antimicrobials for growth promotion and a restriction of using them for non-diagnosed illnesses.

WHO classifies medically important antimicrobials as those that are critically important for human medicine.

The FDA released a five-year plan in September that supports steps to eliminate the use of these medically important antimicrobials in animal production. They include using antimicrobials only under the instruction of veterinarians and supporting the judicious use of the drugs in food animals, meaning they should only be used “when necessary for the treatment, control or prevention of specific diseases.”

“In simple terms, we believe medically important antimicrobial drugs should only be used when necessary to treat, control or prevent diseases. in addition, when such use is necessary, these antimicrobials should be used in an optimal manner. they should only be used under the oversight of a licensed veterinarian,” FDA Commissioner Dr. Scott Gottlieb said in a statement in July.

Get CNN Health's weekly newsletter

Sign up here to get The Results Are In with Dr. Sanjay Gupta every Tuesday from the CNN Health team.

For Brook, the consumer voice is an important one in the long-term goal of eliminating routine antibiotic use in livestock.

She encourages people to ask questions whenever they are making choices about meat, whether in a grocery store or in a restaurant, and to express a desire for meat that is raised without the routine use of antibiotics.

Corporations also listen to consumers, she says. “Communicating that desire on a more personal level but also on that kind of bigger platform through the campaigns that nonprofits are running and also through social media, I think, is really important.”