Ongoing outbreak of rare eye infection found among contact lens wearers

Some patients with Acanthamoeba keratitis require cornea transplants.

Story highlights

  • Rates of Acanthamoeba keratitis, an infection of the cornea, tripled since 2011 in the southeast of England
  • Only 70% of patients are cured within 12 months, and some require cornea transplants

(CNN)An ongoing outbreak of a rare eye infection has been discovered in contact lens wearers in the UK, a new study reveals.

Researchers at University College London found that rates of Acanthamoeba keratitis, an infection of the cornea, have nearly tripled since 2011 in the southeast of England.
Infection with Acanthamoeba, a cyst-forming microorganism, causes an inflammation of the cornea. Symptoms include excessive pain and compromised vision.
    The disease is mostly preventable, said Dr. John Dart, a consultant ophthalmologist at Moorfields Eye Hospital who led the research.
    The infection is caused by the microorganism Acanthamoeba.
    "It was clear that there is a problem," he said. "Acanthamoeba keratitis is one of the worst corneal infections."
    Studies suggest that about 2 in 100,000 contact lens wearers in the UK are affected each year, aided by the way water is stored and supplied there, according to Moorfields Eye Hospital, meaning case numbers are higher in the UK than in other parts of the world.
    In the United States, the Centers for Disease Control and Prevention estimates occurrence at one or two cases in every million lens wearers; 85% of cases will occur in lens wearers.
    The new study identified a surge in the UK.
    Dart's team analyzed incidence data collected by Moorfields, where cases across the southeast of England are treated, and found an average of 50.3 cases of Acanthamoeba keratitis per year between 2011 and 2016, up from an average of 18.5 in prior years, between outbreaks.
    "Acanthamoeba keratitis is a rare infection, but when it occurs, it has a devastating effect for a long period of time on the patient's life," Dart said. "Only 70% of patients were cured within 12 months. For the remaining 30%, the treatment took over a year."
    The researchers say their findings apply across the UK, given that Moorfields Eye Hospital treats more than 35% of the country's cases.
    Acanthamoeba keratitis is 20 times less likely than bacterial infections among contact lens wearers. Severe occurrences take up to 10 months to treat with antiseptic eye drops followed by 38 months of followup visits, according to the new study.
    The most severe cases also lead to a permanent 75% decrease in vision because of scarring of the cornea, with a quarter of patients requiring corneal transplants, Dart said. He explained that corneal transplant surgeries are sometimes necessary to treat holes in patients' eyes due to ulcers caused by the infection or to restore vision.
    Irenie Ekkeshis, a 39-year-old daily disposable contact lens wearer, was diagnosed with Acanthamoeba keratitis in 2011, despite strict lens hygiene.
    Irenie Ekkeshis, 39, developed Acanthamoeba keratitis in 2011.
    She remembers waking one morning in January that year with horrific pain and a sore eye "that was very sensitive to bright light." The pain worsened over time, and Ekkeshis knew that something was "very wrong" with her eye.
    Her treatment took three years because the standard treatment with antiseptic eye drops was not effective. She had to undergo several other procedures, inclu