Now playing
01:42
Merkley: Violence on Gaza border 'horrific'
TOPSHOT - Palestinian protesters pull a metal cable as they try to take down a section of barbed wire during clashes with Israeli forces on April 20, 2018, east of Khan Yunis, in the southern Gaza Strip during mass protests along the border of the Palestinian enclave, dubbed "The Great March of Return," which has the backing of Gaza's Islamist rulers Hamas. (Photo by SAID KHATIB / AFP)        (Photo credit should read SAID KHATIB/AFP/Getty Images)
SAID KHATIB/AFP/AFP/Getty Images
TOPSHOT - Palestinian protesters pull a metal cable as they try to take down a section of barbed wire during clashes with Israeli forces on April 20, 2018, east of Khan Yunis, in the southern Gaza Strip during mass protests along the border of the Palestinian enclave, dubbed "The Great March of Return," which has the backing of Gaza's Islamist rulers Hamas. (Photo by SAID KHATIB / AFP) (Photo credit should read SAID KHATIB/AFP/Getty Images)
Now playing
02:11
The history of Gaza in 2 minutes
dpatop - Palestinian protesters use slingshots to hurl stones towards Israeli security forces during clashes along the Israel-Gaza border, on the 70th anniversary of Nakba Day (Day of the Catastrophe), which marks the displacement that preceded and followed the Israeli Declaration of Independence in 1948, in Khan Yunis, Southern Gaza Strip, 14 May 2018. Photo by: Wissam Nassar/picture-alliance/dpa/AP Images
Wissam Nassar/picture-alliance/dpa/AP Images
dpatop - Palestinian protesters use slingshots to hurl stones towards Israeli security forces during clashes along the Israel-Gaza border, on the 70th anniversary of Nakba Day (Day of the Catastrophe), which marks the displacement that preceded and followed the Israeli Declaration of Independence in 1948, in Khan Yunis, Southern Gaza Strip, 14 May 2018. Photo by: Wissam Nassar/picture-alliance/dpa/AP Images
Now playing
02:06
What sparked the latest Palestinian protests?
An injured Palestinian woman is carried by protesters as they run for cover during clashes with Israeli security forces following a demonstration commemorating Land Day near the border with Israel, east of Khan Yunis, in the southern Gaza Strip on March 30, 2018.
Clashes erupted as thousands of Gazans marched near the Israeli border in a major protest dubbed "The Great March of Return". / AFP PHOTO / SAID KHATIB        (Photo credit should read SAID KHATIB/AFP/Getty Images)
SAID KHATIB/AFP/AFP/Getty Images
An injured Palestinian woman is carried by protesters as they run for cover during clashes with Israeli security forces following a demonstration commemorating Land Day near the border with Israel, east of Khan Yunis, in the southern Gaza Strip on March 30, 2018. Clashes erupted as thousands of Gazans marched near the Israeli border in a major protest dubbed "The Great March of Return". / AFP PHOTO / SAID KHATIB (Photo credit should read SAID KHATIB/AFP/Getty Images)
Now playing
02:21
Palestinians: Over a dozen killed in protests
Abid Katib/OREL COHEN/AFP/Getty Images
Now playing
00:51
What's the Israeli-Palestinian two-state solution?
UNTV
Now playing
01:31
Haley to Abbas: US embassy decision is final
CNN
Now playing
07:22
Spokesman: Deliberate violence in Gaza
jerusalem palestine shuafat refugee camp liebermann pkg_00010911.jpg
jerusalem palestine shuafat refugee camp liebermann pkg_00010911.jpg
Now playing
02:00
Refugee camp island of isolation in Jerusalem
Now playing
02:36
Trump: Good chance for Middle East peace
A picture shows the skyline of Jerusalem with the Dome of the Rock mosque, at the Al-Aqsa mosque compound in the city?s old city, where thousands of Muslim pilgrims crowded for the first Friday noon prayer of Ramadan on September 5, 2008. Israel beefed up its police deployments in Jerusalem as tens of thousands of Muslim faithful were expected to attend the first Friday prayers of Ramadan at the Al-Aqsa mosque compound in the Old City. AFP PHOTO/MARCO LONGARI (Photo credit should read MARCO LONGARI/AFP/Getty Images)
MARCO LONGARI/AFP/AFP/Getty Images
A picture shows the skyline of Jerusalem with the Dome of the Rock mosque, at the Al-Aqsa mosque compound in the city?s old city, where thousands of Muslim pilgrims crowded for the first Friday noon prayer of Ramadan on September 5, 2008. Israel beefed up its police deployments in Jerusalem as tens of thousands of Muslim faithful were expected to attend the first Friday prayers of Ramadan at the Al-Aqsa mosque compound in the Old City. AFP PHOTO/MARCO LONGARI (Photo credit should read MARCO LONGARI/AFP/Getty Images)
Now playing
03:21
How the Six Day War reshaped the Middle East
exp ctw grief of a palestinian mother _00010203.jpg
exp ctw grief of a palestinian mother _00010203.jpg
Now playing
02:52
Israel-Palestine Conflict: Grief of a mother
Israeli forensics search at the scene of an explosion on a bus in Jerusalem on April 18, 2016.
THOMAS COEX/AFP/Getty Images
Israeli forensics search at the scene of an explosion on a bus in Jerusalem on April 18, 2016.
Now playing
01:09
Police: Bus explosion 'no doubt' was an attack
israeli police confirm device in bus fire liebermann_00001307.jpg
Getty Images
israeli police confirm device in bus fire liebermann_00001307.jpg
Now playing
03:05
Israeli police confirm explosive device in bus fire
Jerusalem bus explosion_00005513.jpg
Jerusalem bus explosion_00005513.jpg
Now playing
01:04
Bus catches fire in Jerusalem
(CNN) —  

Sen. Jeff Merkley, D-Oregon, called Monday’s violence on the Gaza border “horrific” and said Palestinians view the US embassy’s move to Jerusalem as the end of the two-state solution.

Protests broke out Monday on the Israel-Gaza border, where according to the Palestinian Health Ministry, more than 50 people died during protests over

“The situation is certainly horrific, and I think that symbolically this move represents for many Palestinians the end of their hopes for a two-state solution,” Merkley said Monday night on CNN’s “Erin Burnett OutFront,” referring to the idea that a Palestinian state and an Israeli state can coexist.

Merkley, who sits on the Senate Foreign Relations Committee, said he has “very much” supported moving the embassy from Tel Aviv, but “when it is part of a strategy to go forward with two people living productively, peacefully, side-by-side.”

“The symbolism really represents to people living in the West Bank and Gaza that there is no path for them to ever have a land of their own, they’ve been under occupation,” Merkley told Burnett. “It’s an extraordinarily difficult life, and we have – we, the United States – have championed the vision that there would be a future, a brighter future ahead.”

President Donald Trump’s administration announced it was breaking with long-held tradition and moving the US Embassy to Jerusalem from Tel Aviv, but the relocation officially took place on Monday – a move that has been praised by Israeli Prime Minister Benjamin Netanyahu.

“What an amazing day! Thank you, @POTUS Trump,” Netanyahu said in a retweet to Trump.

Most people who died were killed by Israeli fire near the border, and more than 2,700 people were injured. CNN journalists heard gunshots in spurts and saw a tank moving towards the fence in the border area of Malaka. Israeli drones also dropped tear gas in an effort to disperse protesters.

The death toll on Monday was the most fatalities seen in one day since the protests started more than six weeks ago.

“Well there was a lot of bloodshed today, I don’t think this will be seen as the beginning of peace,” Merkley said about the embassy’s move.

CNN’s Ian Lee, Tamara Qiblawi, Abeer Salman, Nicole Gaouette and James Masters contributed to this report.