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Iranian women chant slogans during an anti-US demonstration outside the former US embassy headquarters in the capital Tehran on May 9, 2018. - Iranians reacted with a mix of sadness, resignation and defiance on May 9 to US President Donald Trump's withdrawal from the nuclear deal, with sharp divisions among officials on how best to respond.
For many, Trump's decision on Tuesday to pull out of the landmark nuclear deal marked the final death knell for the hope created when it was signed in 2015 that Iran might finally escape decades of isolation and US hostility. (Photo by ATTA KENARE / AFP)        (Photo credit should read ATTA KENARE/AFP/Getty Images)
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Iranian women chant slogans during an anti-US demonstration outside the former US embassy headquarters in the capital Tehran on May 9, 2018. - Iranians reacted with a mix of sadness, resignation and defiance on May 9 to US President Donald Trump's withdrawal from the nuclear deal, with sharp divisions among officials on how best to respond. For many, Trump's decision on Tuesday to pull out of the landmark nuclear deal marked the final death knell for the hope created when it was signed in 2015 that Iran might finally escape decades of isolation and US hostility. (Photo by ATTA KENARE / AFP) (Photo credit should read ATTA KENARE/AFP/Getty Images)
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Iranian lawmakers burn two pieces of papers representing the U.S. flag and the nuclear deal as they chant slogans against the U.S. at the parliament in Tehran, Iran, Wednesday, May 9, 2018. Iranian lawmakers have set a paper U.S. flag ablaze at parliament after President Donald Trump's nuclear deal pullout, shouting, "Death to America!". President Donald Trump withdrew the U.S. from the deal on Tuesday and restored harsh sanctions against Iran. (AP Photo)
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Iranian lawmakers burn two pieces of papers representing the U.S. flag and the nuclear deal as they chant slogans against the U.S. at the parliament in Tehran, Iran, Wednesday, May 9, 2018. Iranian lawmakers have set a paper U.S. flag ablaze at parliament after President Donald Trump's nuclear deal pullout, shouting, "Death to America!". President Donald Trump withdrew the U.S. from the deal on Tuesday and restored harsh sanctions against Iran. (AP Photo)
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ISFAHAN, IRAN - MARCH 30:  A worker walks inside of an uranium conversion facility March 30, 2005 just outside the city of Isfahan, about 254 miles (410 kilometers), south of capital Tehran, Iran. The cities of Isfahan and Natanz in central Iran are home to the heart of Iran's nuclear program. The facility in Isfahan makes hexaflouride gas, which is then enriched by feeding it into centrifuges at a facility in Natanz, Iran. Iran's President Mohammad Khatami and the head of Iran's Atomic Energy Organisation Gholamreza Aghazadeh is scheduled to visit the facilities. (Photo by Getty Images)
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(CNN) —  

President Donald Trump announced Tuesday he is quitting the Iran nuclear deal, pitting him against the United States’ closest allies and leaving the future of Tehran’s nuclear ambitions in question.

“It is clear to me that we cannot prevent an Iranian nuclear bomb under the decaying and rotten structure of the current agreement,” Trump said from the White House Diplomatic Room. “The Iran deal is defective at its core. If we do nothing we know exactly what will happen.”

In announcing his long-telegraphed decision, Trump said he would initiate new sanctions on the regime, crippling the touchstone agreement negotiated by his predecessor. Trump said any country that helps Iran obtain nuclear weapons would also be “strongly sanctioned.”

“This was a horrible one-sided deal that should have never, ever been made,” the President said in remarks that, at times, misrepresented the international agreement’s provisions. “It didn’t bring calm, it didn’t bring peace, and it never will.”

Trump’s decision could have explosive consequences, straining longstanding US alliances, disrupting oil markets and boosting tensions in the Middle East, even if the US reversal doesn’t lead Iran to restart its atomic program.

While Trump supporters praised the move, analysts and critics said it undermines Washington’s credibility in future negotiations – particularly with North Korea – and potentially empowers the very hardliners in Iran that Trump vilified in his remarks.

It also further isolates Trump on the global stage, where he has angered even the staunchest US allies by reneging on US commitments to the Paris climate accord and pulling out of the Trans-Pacific Partnership trade agreement.

Reaction was swift

Former President Barack Obama, who rarely comments on his successor, issued a statement describing Trump’s move as a “serious mistake” that could leave the US with a “losing choice between a nuclear-armed Iran or another war in the Middle East.”

Some of the US’ closest allies, the UK, France and Germany, issued a statement expressing “regret and concern” about the decision, emphasizing Iran’s compliance with the deal and their “continuing commitment” to the Joint Commission Plan of Action, as the deal is formally known.

Iran’s President, Hassan Rouhani, said he had ordered the country’s atomic industry to be ready to restart industrial uranium enrichment, while the country’s foreign minister said he would work with the pact’s remaining partners – France, the UK, Germany, China and Russia – to see whether they could ensure “full benefits for Iran. Outcome will determine our response,” Javad Zarif tweeted.

Tensions in the region are high, with US officials citing “concerns” that Iran might attack Israel, without citing their evidence for the claim, while Israel called up reserves and the State Department issued a security alert for US citizens in the Golan Heights.

Turkish President Recep Tayyip Erdogan told CNN that he fears that “new crises” will break out in the Middle East as a result of the US decision.

“We don’t need new crises in the region,” Erdogan told CNN’s Becky Anderson.

US foes used the decision to portray the US as an international outlier, underscoring that the US, not Iran, is now technically in violation of the deal.

“The position promulgated by Washington represents a significant violation of the JCPOA,” the Russian foreign ministry said in a statement, describing Trump’s decision as “new confirmation of Washington’s incompetence.”

The Russians also said that US “claims regarding Iran’s absolutely legitimate nuclear activities are just a cover for keeping political scores with the country.”

Indeed, senior Trump administration officials – including Secretary of State Mike Pompeo and the Director of National Intelligence Daniel Coats – have said Iran is adhering to its commitments under the deal.

But Trump has argued while they may be sticking to the letter of the accord, they have violated its spirit by fostering discord in the region, supporting groups like Hezbollah, Houthi rebels in Yemen, and the Syrian regime.

Trump derided the deal as an embarrassment that gave the regime dollars at the same time it sponsored terrorism.