Studies have shown that there is an association with Frank's sign, the visible external crease on the earlobe, and increased risk of atherosclerosis, a disease in which plaque builds up inside your arteries.
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Yellow, fatty bumps known as xanthomas can appear on the elbows, knees, buttocks or eyelids. The bumps themselves are harmless, but they can be a sign of bigger problems.
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A phenomenon known as digital clubbing may also be a sign that all is not well with your heart. The fingernails change shape, becoming thicker and wider.
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Fat deposits may also be seen as a gray ring around the outside of the iris, the colored part of the eye.
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Studies have shown that tooth loss and inflamed gums (periodontitis) are markers of heart disease.
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The lips are usually red, but they can take on a bluish color (cyanosis) in people with heart problems due to the failure of the cardiovascular system to deliver oxygenated blood to tissues.