WASHINGTON, DC - SEPTEMBER 27:  Secretary of Veterans Affairs David Shulkin (L) testifies before the Senate Veterans Affairs Committee September 27, 2017 in Washington, DC. The committee heard testimony on the topic of "Be There: What more can be done to prevent veteran suicide?"  (Photo by Win McNamee/Getty Images)
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WASHINGTON, DC - SEPTEMBER 27: Secretary of Veterans Affairs David Shulkin (L) testifies before the Senate Veterans Affairs Committee September 27, 2017 in Washington, DC. The committee heard testimony on the topic of "Be There: What more can be done to prevent veteran suicide?" (Photo by Win McNamee/Getty Images)
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(CNN) —  

President Donald Trump announced Wednesday he will replace his Veterans Affairs Secretary David Shulkin with Ronny Jackson, who currently serves as physician to the President.

Trump thanked Shulkin via Twitter for his “service to our country and to our GREAT VETERANS” and said Robert Wilkie, the under secretary of defense for personnel and readiness, will serve as acting secretary until Jackson is confirmed.

A White House official said the embattled Shulkin was no longer effective in his role, saying his “distractions were getting in the way of carrying out the President’s agenda.”

RELATED: Who is Dr. Ronny Jackson?

Shulkin is the second member of Trump’s Cabinet to be ousted this month, following Secretary of State Rex Tillerson. A handful of senior White House officials have also resigned or been fired over the last two months, fueling chaos and uncertainty inside the West Wing.

Jackson, who is an active duty Navy physician, was nominated last week for a military promotion by the President. He was appointed as physician to the president by President Barack Obama in 2013, after having served on the White House medical team since 2006. He continued in that role after Trump came into office and quickly developed a bond with the President.

“He’s like central casting – like a Hollywood star,” Trump told donors during a fundraiser at Mar-a-Lago last month, according to audio of his remarks obtained by CNN.

Jackson took on an unusually public role for a presidential physician earlier this year when he took to the White House briefing room to field questions about Trump’s health, just days after questions about Trump’s mental fitness for office were raised.

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Shulkin’s departure from the administration is a stark reversal of fortunes for the VA leader, who served as undersecretary of health in the Obama administration. He’d been held in high regard by Trump, who publicly praised him and touted a series of legislative wins regarding veterans issues.

Soured on Shulkin

Trump even joked last year that his signature phrase, “you’re fired” would never be used with Shulkin.