Prior to the assassination, President John F. Kennedy, First Lady Jacqueline Kennedy, and Texas Governor John Connally ride through the streets of Dallas, Texas on November 22, 1963. Included as an exhibit for the Warren Commission. (Photo by © CORBIS/Corbis via Getty Images)
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Prior to the assassination, President John F. Kennedy, First Lady Jacqueline Kennedy, and Texas Governor John Connally ride through the streets of Dallas, Texas on November 22, 1963. Included as an exhibit for the Warren Commission. (Photo by © CORBIS/Corbis via Getty Images)
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Program note: Explore the Kennedy family’s rise to power on “American Dynasties: The Kennedys” Sundays at 9 p.m. ET/PT on CNN TV and CNNGo.

(CNN) —  

The death of Robert F. Kennedy’s granddaughter adds to a series of tragedies that have befallen America’s prominent political dynasty for generations.

For some, the string of untimely deaths and scandals in President John F. Kennedy’s family may seem too unlikely to chalk up as bad luck.

In fact, JFK’s brother, the late Sen. Edward “Ted” Kennedy, actually wondered out loud if his family were victims of an “awful curse” — as if curses could be real.

Most people know about the assassinations of President Kennedy and his brother Robert F. Kennedy in the 1960s.

But, depending on your generation, these other terrible events within the Kennedy clan may not be so well known.

John F. Kennedy Jr. and his wife, Carolyn Bessette Kennedy, in May 1999, a few months before they died in a plane crash.
Manny Ceneta/AFP/Getty Images
John F. Kennedy Jr. and his wife, Carolyn Bessette Kennedy, in May 1999, a few months before they died in a plane crash.

1. The Kennedy family’s history of deadly plane crashes

Many remember the 1999 small plane crash off Massachusetts that killed JFK’s son, John F. Kennedy Jr., his wife, Carolyn Bessette Kennedy, and sister-in-law Lauren Bessette. The crash was blamed on JFK Jr., who was piloting the plane at night and became disoriented before crashing into the Atlantic.

But perhaps not as well known: 35 years earlier, Ted Kennedy survived a 1964 plane crash that killed two people.

JFK's brother Sen. Edward "Ted" Kennedy survived this deadly plane crash in Massachusetts in 1964.
Charles Dixon/The Boston Globe/Getty Images
JFK's brother Sen. Edward "Ted" Kennedy survived this deadly plane crash in Massachusetts in 1964.

This tragedy happened during a campaign flight from Washington to Westfield, Massachusetts. Ted Kennedy was flying with a fellow senator, the senator’s wife and a legislative aide. The pilot and aide were killed.

Low clouds and fog made flying difficult as the plane approached Westfield’s airport. The plane lost altitude and crashed in an orchard not far from the runway, killing the pilot and the aide.

Kennedy suffered a broken back and ribs. Federal investigators blamed the crash on pilot error.

Ted Kennedy wondered if his family fell victim to an "awful curse."
Barbara Alper/Getty Images
Ted Kennedy wondered if his family fell victim to an "awful curse."

President Kennedy’s oldest brother, Joe Kennedy Jr., died in a 1944 air disaster, after volunteering to pilot a secret and extremely dangerous World War II bombing mission in Nazi-occupied France.

During the mission, two in-flight explosions rocked his bomber aircraft “resulting in the death of its two pilots,” according to the JFK Presidential Library. The cause of the explosions remain a mystery.

Joseph P. Kennedy Jr.
Bettmann Archive/Getty Images
Joseph P. Kennedy Jr.

Four years after the family lost Joe Jr., another plane crash killed President Kennedy’s sister Kathleen Kennedy, who was nicknamed “Kick.”

Kathleen "Kick" Kennedy was close to her brother and future president, John F. Kennedy.
Horace Abrahams/Hulton Archive/Getty Images
Kathleen "Kick" Kennedy was close to her brother and future president, John F. Kennedy.

Kick Kennedy had married William Cavendish, England’s Marquess of Hartington, giving her the title Lady Hartington. In 1948, she and three others died when their small plane crashed in France while flying in a storm. She was 28.

Kick Kennedy Cavandish died in a 1948 plane crash in France.
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Kick Kennedy Cavandish died in a 1948 plane crash in France.

2. Woman dies in car driven by Ted Kennedy

It was known simply as Chappaquiddick, the tragedy that followed Ted Kennedy throughout his political career. Chappaquiddick was the Massachusetts island where campaign worker Mary Jo Kopechne died in a 1969 car crash, with Kennedy at the wheel.

Kennedy was driving Kopechne home after a late-night party when he lost control of the vehicle and crashed into the water. Kopechne was trapped inside the car but Kennedy was able to swim ashore and walked back to his hotel.

He didn’t alert police until 10 hours later.

Eventually Kennedy pleaded guilty to leaving the scene of an accident and received a two-month suspended sentence.

He went on national TV to explain the tragedy, saying, “All kinds of scrambled thoughts … went through my mind … including such questions as … whether some awful curse did actually hang over all the Kennedys.”

A film titled “Chappaquiddick,” starring Kate Mara as Mary Jo Kopechne, is scheduled to hit theaters in April.

Mary Jo Kopeckne died after Ted Kennedy drove off a bridge on Chappaquiddick Island in 1969.
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Mary Jo Kopeckne died after Ted Kennedy drove off a bridge on Chappaquiddick Island in 1969.

A drug overdose

In 1984, David Kennedy, one of Ethel and Robert F. Kennedy’s children, died in a Florida hotel after a drug overdose. He reportedly watched his father’s assassination on live TV as a boy and later struggled with addiction. He was 28.

Family members accompany David Kennedy's body after his 1984 drug overdose.
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Family members accompany David Kennedy's body after his 1984 drug overdose.

A skiing accident

Michael Kennedy, another son of the late Robert F. Kennedy, died in 1997 during a ski accident in Colorado on New Year’s Eve. The New York Times reported that he was tossing a football with relatives while skiing down a mountain. The father of three was 39.

Family members carry a casket with the body of Michael Kennedy following a memorial service in 1997.
Allan Tannenbaum/The LIFE Images Collection/Getty Images
Family members carry a casket with the body of Michael Kennedy following a memorial service in 1997.

5. Kennedy nephew accused of rape

In 1991, Ted Kennedy was forced to testify about a bar-hopping weekend near the family’s vacation home in Palm Beach, Florida, that led to sexual battery charges against his nephew, William Kennedy Smith.

Smith was accused of raping a woman that he and the senator met at a trendy nightclub called Au Bar.

Eventually Smith was acquitted of all charges.

Because the trial was allowed to be televised live, cable news channels, including CNN and the newly launched Court TV, provided virtually nonstop coverage of testimony, creating fodder for the tabloid press, much to the chagrin of the Kennedy family.

Most news outlets chose not to identify Kennedy Smith’s accuser, whose face was covered by a blue blob during her testimony.

After Ted Kennedy’s emotional testimony, Kennedy Smith said of his uncle, “I think this process has been unfair to him,” Vanity Fair reported.

In 1991, William Kennedy Smith was tried and acquitted on sexual assault charges.
Lannis Waters/Sygma/Getty Images
In 1991, William Kennedy Smith was tried and acquitted on sexual assault charges.

6. Kennedy cousin Michael Skakel convicted of murder

Michael Skakel, nephew of Robert F. Kennedy’s widow Ethel Kennedy, was convicted in 2002 of bludgeoning his neighbor, Martha Moxley to death during a jealous rage in 1975. Both were 15 at the time of the killing and lived near each other in Greenwich, Connecticut.

In 2013, he was granted a new trial and freed on bail. Three years later, prosecutors appealed the decision and the state Supreme Court reinstated Skakel’s conviction. Skakel has asked the court to reconsider and remains free on bail.

In 1975, Michael Skakel and Martha Moxley were both 15.
Pool/Getty Images
In 1975, Michael Skakel and Martha Moxley were both 15.

A failed brain surgery

President Kennedy’s sister, Rosemary Kennedy, had part of her brain removed in 1941 in a relatively new procedure known as a prefrontal lobotomy. The family had long described her as “intellectually slow.” The operation only worsened her condition and she was institutionalized until her death in 2005 at age 86.

Eunice Kennedy, left, and her sister Rosemary Kennedy in 1938.
Bettmann Archive/Getty Images
Eunice Kennedy, left, and her sister Rosemary Kennedy in 1938.

An infant son dies

In 1963, President Kennedy and first lady Jacqueline Kennedy suffered yet another loss.

The President and first lady Jacqueline Kennedy at the White House in 1963.
National Archives
The President and first lady Jacqueline Kennedy at the White House in 1963.

A cancer battle

Cancer has also played a role in the Kennedy family tragedies.