Hall of Fame offensive lineman Mike Webster was the first former NFL player to be diagnosed with CTE. After his retirement, Webster suffered from amnesia, dementia, depression, and bone and muscle pain.
Evidence of CTE was found in the brain of football player Lew Carpenter after his death in 2010 at the age of 78.
Pro Football Hall of Famer Louis Creekmur, who played for the Detroit Lions from 1950 to 1959, suffered decades of cognitive decline before his death.
Linebacker John Grimsley of the Houston Oilers died of an accidental gunshot wound to the chest in 2008. Analysis of his brain tissue confirmed damage to the neurofibrillary tangles that had begun to affect his behavior and memory.