One of the most senior figures in the Vatican, Pell appeared at Melbourne Magistrates' Court Friday after he was charged by detectives from Victoria Police in June.
He is fighting multiple allegations of historic sexual abuse, although the details of the charges have not been made public.
His barrister Robert Richter QC already told the court in the first hearing in July his client would plead not guilty.
Cardinal Pell, who has stood down from his role in Rome to face court in his home country, has repeatedly and vehemently denied the allegations.
The witnesses will give evidence and will be cross-examined during a month-long committal hearing scheduled to take place from March 5 next year.
The committal hearing will determine whether there is enough evidence to commit him to stand trial at a higher court.
A huge media scrum followed Pell as he arrived and left court on Friday and supporters and protestors crowded for a chance to see the cardinal.
The 76-year-old has been given a leave of absence from his role at the Holy See as prefect of the Secretariat for the Economy while he fights the case in the city where he was once Archbishop.
'I am innocent of these charges'
Pell is the most senior cardinal in the history of the Catholic Church ever to face criminal charges.
The cardinal has long been a prominent figure in Australia's Catholic Church, serving first as the Archbishop of Melbourne and then the Archbishop of Sydney before heading to the Vatican.
Before taking a leave of absence, he was considered one of Pope Francis' top advisers.
Speaking at a media conference at the Holy See's press office in June after being charged he said: "I am looking forward, finally, to having my day in court.
"I am innocent of these charges; they are false. The whole idea of sexual abuse is abhorrent to me."
According to figures in the report, 7% of Australian priests were accused of abusing children between 1950 and 2010.
Additionally, the commission stated the Catholic Church had been reluctant to investigate the reported abuse and helped to cover up incident when they were reported.