"A lot of people don't know I'm from Puerto Rico," he told CNN on Monday. "I have my family there, I have my wife, my daughter, and I live there still ... and we really need your help."
The singer-rapper told CNN the devastation has been catastrophic and urged everyone, including the US government, to do more.
"A lot of people don't know Puerto Ricans are American citizens ... we need the federal money for the citizens and for the government to help the locals."
Appearing on CNN's "New Day" and while hosting a CNN Instagram live, Daddy Yankee emphasized the scale of the destruction by telling people to contrast the scenes in the "Despacito" music video to images of hurricane damage they're seeing now.
The video, which has more than 3.8 billion views on YouTube
, was filmed in the San Juan neighborhood of La Perla. It features Luis Fonsi and Daddy Yankee singing against a colorful backdrop of Puerto Rican street performers.
"Watching the images of the video and comparing it to the images I've seen so far -- it's devastated," said the singer, whose real name is Ramón Luis Ayala Rodríguez.
"I know a lot of people are struggling. There's no communication, no power on the island, the hospitals are not working," he added. "We need the government to be more proactive."
Yankee said he has personally donated $100,000 to Feeding America and another $100,000 to the Red Cross, as well as encouraging his fans to donate items such as water, insect repellent and batteries that he plans to personally bring to the island this weekend.
"We're doing the best we can, but we can't do it alone. We need everyone to get involved," he said.
To find out how you can help, head to CNN's Impact your World
page for a list of organizations working on the ground.
Correction: A previous version of this story incorrectly stated the amount Daddy Yankee donated to Feed America and the Red Cross. The correct amount is $100,000 to each charity.