Seven reasons we’re at more risk than ever of a global pandemic

Updated 2:21 PM EDT, Mon April 10, 2017
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As people cross borders regularly and live closer together, the risk of outbreaks is greater than ever

Experts say climate change and civil unrest are also contributing to the risk

(CNN) —  

It could take just one cough, one kiss, one touch or even one bite to change not only your life, but the lives of everyone around you – and for months or even years.

In most cases, the closer those people are to you, the greater the risk. But it isn’t always that simple.

The risk at hand: an infectious outbreak.

Public health experts believe we are at greater risk than ever of experiencing large-scale outbreaks and global pandemics like those we’ve seen before: SARS, swine flu, Ebola and Zika.

More than 28,000 people were infected during the 2014-16 Ebola epidemic, with over 11,000 deaths. And as of March 10, 84 countries have reported Zika transmission. That disease was discovered in the 1940s, but had its first outbreak in 2007 in Micronesia, and more recently began spreading toward the end of 2015.

Every time, the infection’s arrival is unexpected and its scale unprecedented, leaving the world vulnerable.

Experts are unanimous in the belief that the next outbreak contender will most likely be a surprise – and we need to be ready.

“We’re only as secure in the world as the weakest country,” said Jimmy Whitworth, professor of international public health at the London School of Hygiene & Tropical Medicine. With so many health systems and economies in a fragile state, this means we are far from secure.

“Infectious diseases respect no boundaries,” he said. The World Health Organization is alerted to hundreds of small outbreaks every month, he noted, which it investigates and uses to predict the chances of a bigger problem.

“There are little clusters of outbreaks occurring all the time, all over the place,” Whitworth said.

But with infections disregarding borders and their battle lines against humans drawn, he believes the way we live today is what opens us up to risk.

“(Many) aspects of modern life put us at more risk. We are more ready than before,” he points out, highlighting the International Health Regulations Global Outbreak Alert and Response Network and countries with national rapid response teams – such as the United States, UK and China – ready to tackle any emergency.

“But the stakes keep getting raised,” he said. Here’s why.

1. Growing populations and urbanization

The facts around urban living are simple: You live, eat, work and move closer to people than in any rural setting, and with this comes greater opportunity for disease to spread through air, mosquitoes or unclean water.

As populations grow, so will the number of city-dwellers, with the United Nations predicting that 66% of the global population will live in urban areas by 2050.

More people in cities can “put a strain on sanitation,” said David Heymann, head of the Centre for Global Health Security at the think tank Chatham House. Beyond people’s close proximity, “this is a second source of infection,” he said, and a third is increased food demand, causing farmers to grow more food, with more animals, making them likely to live closer to those animals as well.

Animals are reservoirs for many diseases, including cattle for tuberculosis and African sleeping sickness (trypanosomiasis) and poultry for avian flu.

With people moving more regularly from – and between – rural settings to urban ones, the chances of them becoming infected and then living in close quarters with others further boosts the potential for things to spread.

2. Encroaching into new environments

As numbers of people grow, so does the amount of land needed to house them. Populations expand into previously uninhabited territories, such as forests. With new territories comes contact with new animals and, inevitably, new infections.

For one example, “Lassa fever occurs because people live in the forest and destroy it for farming,” Heymann said.

Lassa fever is a viral disease spread by contact with the feces of infected rodents. It can cause fever and hemorrhaging of various parts of the body, including the eyes and nose. Person-to-person transmission is also possible, albeit less common. Outbreaks generally occur in West Africa, with higher than expected rates in Nigeria since 2016.

Heymann explains that Lassa is one example of people living near forest environments where infected rodents reside, but destruction of those forests for agriculture leaves the animals nowhere to go – other than humans’ homes.

“The rodents that live there can’t get food and go into human areas for food,” he said.

3. Climate change

Evidence continues to emerge that climate change is resulting in greater numbers of heat waves and flooding events, bringing more opportunity for waterborne diseases such as cholera and for disease vectors such as mosquitoes in new regions.

“Flooding is occurring with increased frequency,” Heymann said, and with that comes greater risk of outbreaks.

Between 2030 and 2050, climate change is projected to cause about 250,000 additional deaths per year from heat stress, malnutrition and the spread of infectious diseases like malaria, according to the World Health Organization.

With disease carriers like mosquitoes increasingly able to live in new unprotected territory, the risk of an outbreak is high.

Whitworth cited the current yellow fever outbreak in Angola, which has infected more than 350 people. He explained that as workers from China returned home from Angola, any yellow fever infection could have been transmitted by mosquitoes in China.

But, the workers’ return in winter meant the insects weren’t around to transmit through bites.

4. Global travel

“We’re vulnerable because of increased travel,” Whitworth said.

International tourist arrivals reached a record of almost 1.2 billion in 2015, according to the UN World Tourism Organization, 50 million more than 2014. It was the sixth consecutive year of above-average growth. And with greater numbers moving at all times come greater options for infections to hop a ride.

Global travel enables infections to spread before symptoms develop.
CARL DE SOUZA/AFP/Getty Images
Global travel enables infections to spread before symptoms develop.

“Infectious agents travel around in humans many times within their incubation period,” Heymann said. An incubation period is the time between infection and the onset of symptoms, meaning people can transmit an infection though they won’t appear to be sick.

The SARS (severe acute respiratory syndrome) pandemic of 2003 is thought to have begun with Dr. Liu Jianlun, who developed symptoms of the airborne virus on a trip to Huang Xingchu in China and then went to visit family in Hong Kong. He infected people at his hotel and his family. He was then hospitalized and died, as did one of his relatives.

In less than four months, about 4,000 cases and 550 deaths from SARS could be traced to Liu’s stay in Hong Kong. More than 8,000 other people became infected across more than 30 countries worldwide.

But Heymann stresses that “it’s not just humans” who spread disease through travel. Infections spread through insects, food and animals moved between countries. “It’s also trade,” he said, pointing to airport malaria, in which people in airports have become infected with malaria through mosquitoes that have hitched a ride on a plane or in food.

He also described bird flu that was stopped at the Belgian border in Thai eagles being traded as pets in 2004. Guinea rats shipped as pets in the United States in 2003 harbored infections with monkey pox, he noted, which then entered prairie dogs and eventually humans.

5. Civil conflict

“If a health system cannot handle (an outbreak), there’s pandemonium,” Heymann said. He believes that poor hygiene is not a valid excuse anywhere, even in developing settings, as sterilization and hand-washing are straightforward.

Civil unrest can impair the ability of a country's health system to handle an outbreak.
DELIL SOULEIMAN/AFP/Getty Images
Civil unrest can impair the ability of a country's health system to handle an outbreak.

But if a country is on the brink of breakdown from civil unrest, the ability to handle an intense and sudden problem like an outbreak could bring its people to their knees – and allow the infection to flourish.

“Outbreaks can completely paralyze countries,” said Whitworth, citing the 2014 Ebola epidemic in which Sierra Leone, Guinea and Liberia were “quite close to collapsing.”

Civil unrest had plagued all three countries, leaving their economic and health infrastructures in dire need of rebuilding – and ill-prepared for a major infection to strike.

That problem combined with human movement between these three countries and others more globally meant Ebola was able to spread, even though dozens of infections in previous years in nearby Democratic Republic of Congo were self-contained and often resolved themselves.

“If (an infection) stays local, it burns out,” Heymann said. “People learn what to do.”

6. Fewer doctors and nurses in outbreak regions

Beyond weak health systems, countries where outbreaks are more likely to occur – namely, more developing settings – also have fewer doctors and nurses to treat the population. Most have left for better prospects elsewhere.

“We have to deal with that as a reality,” Heymann said, adding that some countries even encourage young medical talent to travel to new regions.

“It’s difficult to manage health worker migration,” he said. But programs and strategies are underway to tackle this by “task-shifting,” moving responsibilities to new groups and training them to deliver care, such as community health workers.

“Communities have to be resilient,” he said, and assigning tasks to people at all levels could mean a greater team available when a new infection strikes.

7. Faster information

In the information age, new levels of communication bring even newer levels of fear and multiple ways to spread it, experts believe.

Although the majority of small outbreaks may once have gone largely unknown by populations farther from the epicenter, people today are more informed than ever and require transparent, factual information to be fast-flowing.

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