Low-calorie sweetener use in kids jumps 200% | CNN

Health effects of artificial sweeteners: Where do we stand? —

Millions of Americans use tabletop artificial sweeteners each day. Millions more eat foods sweetened with combinations of the fake stuff. But just how healthy are they?

The 137-year history of these nonnutritive options is full of health concerns, both overblown and real.

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1879: First artificial sweetener, saccharin, is finger lickin' good-for-you —

Oddly enough, it was bad laboratory technique -- combined with poor hygiene -- that led to the discovery of several of today's top artificial sweeteners.

Russian chemist Constantin Fahlberg was eating dinner when he made an amazing discovery: The roll he'd just bitten into tasted extremely sweet. Realizing the sugary, metallic taste had come from his own hands, he rushed back to the lab to find the source. After tasting everything in sight -- not exactly good lab safety protocol -- he discovered the sweetness came from an accidental chemical reaction between coal tar derivatives (yum!), producing benzoic sulfinide.

That's one version of the story. Another account says Fahlberg's American boss, Dr. Ira Remsen, was the diner who forgot to wash up before eating. Regardless, it was Fahlberg who applied for a patent for saccharin as an inexpensive sugar substitute

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In the early 1900s, a <a href="http://toxsci.oxfordjournals.org/content/67/2/157.full" target="_blank" target="_blank">group of civil servants</a> was given free room and board if the men would eat food heavily laced with widely used chemical preservatives, including borax and saccharin. <br /><br />They were required to weigh in and take their vital signs before each meal and report any physical reactions. They also had to supply their urine and feces for analysis.

1900: Poison Squad eats food heavily laced with saccharin —

In the early 1900s, a group of civil servants was given free room and board if the men would eat food heavily laced with widely used chemical preservatives, including borax and saccharin.

They were required to weigh in and take their vital signs before each meal and report any physical reactions. They also had to supply their urine and feces for analysis.

FDA

The <a href="http://toxsci.oxfordjournals.org/content/67/2/157.full" target="_blank" target="_blank">"Poison Squad' </a>was the brainchild of Dr. Harvey Wiley, chief of the U.S. Department of Agriculture's chemical division. He strongly believed that saccharin was a danger to health and<a href="https://dash.harvard.edu/bitstream/handle/1/8852144/Gaughan.html?sequence=2" target="_blank" target="_blank"> took his case to President Theodore Roosevelt</a>. <br /><br />But Roosevelt would have none of it, as he was using saccharin to manage his weight. Wiley describes the President's reaction in his autobiography: "'You say saccharin is injurious to health? Why, Doctor Rixey gives it to me every day. Anybody who says saccharin is injurious to health is an idiot.'"

1908: Weight-watching President Roosevelt keeps saccharin from being banned —

The "Poison Squad' was the brainchild of Dr. Harvey Wiley, chief of the U.S. Department of Agriculture's chemical division. He strongly believed that saccharin was a danger to health and took his case to President Theodore Roosevelt.

But Roosevelt would have none of it, as he was using saccharin to manage his weight. Wiley describes the President's reaction in his autobiography: "'You say saccharin is injurious to health? Why, Doctor Rixey gives it to me every day. Anybody who says saccharin is injurious to health is an idiot.'"

FDA

The 1970s saw a <a href="http://science.sciencemag.org/content/165/3898/1139.short" target="_blank" target="_blank">number of studies</a> of <a href="http://www.ncbi.nlm.nih.gov/pubmed/5420548" target="_blank" target="_blank">lab rats</a> fed high doses of saccharin and a newly discovered sweetener, cyclamate. Cyclamate was linked to bladder, urinary, lung, stomach and reproductive tumors in the rodents. <br /><br />While later studies found the bladder issues were due to parasites and other urinary peculiarities unique to rats, the damage was done. The FDA banned cyclamate in 1970. While 100 other countries have declared cyclamate safe and use it in their food, the FDA ban remains in the United States.

1970: Cyclamate will give you cancer, if you are a lab rat —

The 1970s saw a number of studies of lab rats fed high doses of saccharin and a newly discovered sweetener, cyclamate. Cyclamate was linked to bladder, urinary, lung, stomach and reproductive tumors in the rodents.

While later studies found the bladder issues were due to parasites and other urinary peculiarities unique to rats, the damage was done. The FDA banned cyclamate in 1970. While 100 other countries have declared cyclamate safe and use it in their food, the FDA ban remains in the United States.

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1977: Saccharin gets a warning label —

Because saccharin had such a bitter, metallic aftertaste, cyclamate was added to the tabletop version, Sweet'N Low, in a 10-1 ratio. When cyclamate was banned, the makers of Sweet'N Low quickly switched to an all-saccharin version, but suspicions remained about saccharin's role as a carcinogen in rats.

In 1977 Congress decreed that any food sweetened with saccharin must carry a scary warning label: "Use of this product may be hazardous to your health. This product contains saccharin which has been determined to cause cancer in laboratory animals."

More studies disproved the connection and in 2000, Congress removed the warning label.

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1965: Another accidental find, in many ways 'Equal' to its predecessors —

Chemist James M. Schlatter was looking for an anti-ulcer drug when he stumbled upon the sweet taste of aspartame by (you guessed it) licking his finger. A mix of aspartic acid and phenylalanine, two naturally occurring amino acids, aspartame entered the growing artificial sweetener market in 1973. Today it's sold as Equal, Nutrasweet or Sugar Twin.

Unlike the other artificial sweeteners, which are usually excreted unchanged, aspartame can be metabolized, so it does have minimal calories (about 4 per gram). It also has some known uncommon health concerns. It should not be used by anyone with the genetic disorder phenylketonuria or certain rare liver disorders, or pregnant women with high levels of phenylalanine in their blood, because it doesn't metabolize properly in those individuals. The FDA requires any food made with aspartame to put that restriction on the label.

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1976: Another brave chemist tastes his delicious experiment —

Scientists were working with a chlorinated sugar compound in 1976 when one of the researchers decided to (what else?) taste it. Sucralose was born. It's made by replacing three hydrogen and oxygen atoms in sucrose with chlorine atoms, making it about 600 times sweeter than sugar.

Today we know this chlorine-based sugar derivative as Splenda. As the most heat-stable of all of the artificial sweeteners, it's popular with food manufacturers.

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2005: Diet sodas cause weight gain —

By 2005, millions of people were using artificial sweeteners for weight control. So it was a shock when researchers at the University of Texas found that conventional wisdom was wrong, when they analyzed eight years of data from the San Antonio Heart Study. The more diet sodas a person drank, the more likely he or she was to gain weight.

To this day, no one knows why. Was it due to the artificial sweetener? Was it something else in the soda? Does drinking a diet soda make it more likely a person might order a double size burger and fries?

Oh, and for the record, a 2013 review says there is still evidence that diet soda helps with weight loss.

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2012: Artificial sweetners probably safe, but some lingering health concerns —

Studying the effects of specific artificial sweeteners is a challenge in today's world, as many soda and food manufacturers create mixtures of sweeteners to mimic sugar and make their products taste unique. So it's hard to tease out which of the sweeteners might be a problem.

But studies continue to find concerns that bear watching. A 2008 study found drinking more than two servings of diet soda a day doubled the risk for kidney decline in women. A 2012 study suggested a possible connection between diet sodas and an increased risk for vascular events. And several studies have discovered a link between metabolic syndrome -- a sort of prediabetes -- and Type 2 diabetes, perhaps because it alters people's gut bacteria.

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History of health concerns for artificial sweeteners

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CNN —

Americans are scarfing down more and more low-calorie sweeteners, and researchers are raising some concerns.

The consumption of low-calorie sweeteners jumped a whopping 200% among children and 54% among adults from 1999 to 2012, according to a study published in the Journal of the Academy of Nutrition and Dietetics on Tuesday.

“We were somewhat surprised,” said Allison Sylvetsky, assistant professor at the Milken Institute School of Public Health at George Washington University, who was lead author of the study.

“While we anticipated an increase, the magnitude of the increase was much larger than we had anticipated, particularly in kids,” she said. “It is not surprising that low-calorie sweetener consumption continues to increase, though. … There has been a lot of pressure put on the food and beverage industry to reformulate, which has led to more lower-sugar, low-calorie sweetener contain

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Low-calorie sweetener use in kids jumps 200%, study finds

History of health concerns for artificial sweeteners

Story highlights