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Republican presidential nominee Donald Trump shakes hands with Democratic presidential nominee Hillary Clinton at the first presidential debate on Monday, September 26. David Goldman/AP
NBC's Lester Holt moderated the debate, which was held at Hofstra University in Hempstead, New York. Joe Raedle/Getty Images
The debate took place 43 days before Election Day. There are two more debates scheduled. Win McNamee/Getty Images
Clinton, 68, is the first woman to lead a presidential ticket for one of the major political parties. She has been a U.S. senator and secretary of state. Andrew Harrer/Bloomberg/Getty Images
This was the first one-on-one debate for Trump, a billionaire real estate developer and neophyte politician. The 70-year-old has shattered every rule and convention in politics with his stunning presidential campaign. Win McNamee/Getty Images
Clinton is clinging to a narrow lead in many national polls, but she now has almost no margin of error in the battleground states that will decide who will take the oath of office in January. Drew Angerer/Getty Images
Trump has been picking up momentum lately in the polls. CNN's Poll of Polls finds Clinton and Trump neck-and-neck nationally, with Clinton leading 44%-42%. Patrick Semansky/AP
Clinton answers a question during the debate. Julio Cortez/AP
The candidates clashed repeatedly over the economy, tax cuts for the wealthy and ISIS. Drew Angerer/Getty Images
Trump smiles during the debate. Win McNamee/Getty Images
Clinton smiles during the debate. Spencer Platt/Getty Images
Trump and Clinton shake hands before the start of the debate. Drew Angerer/Getty Images
The debate was attracting worldwide interest, with a television audience expected to approach 100 million. Drew Angerer/Getty Images
Clinton waves to the crowd after shaking hands with Trump. Evan Vucci/AP
Trump's wife, Melania, shakes hands with Clinton's husband, former U.S. President Bill Clinton. Patrick Semansky/AP
From left, in the front row, are Melania Trump; Trump's daughter Ivanka Trump; Trump's running mate, Indiana Gov. Mike Pence; Pence's wife, Karen; retired U.S. Army Gen. Michael Flynn; and former New York Mayor Rudy Giuliani. Evan Vucci/AP
Bill Clinton, sitting next to daughter Chelsea, waves to the audience before the debate. David Goldman/AP
The crowd was urged to stay quiet throughout the debate, but there was occasional applause and laughs. Spencer Platt/Getty Images
Trump and Clinton face off in the debate. JEWEL SAMAD/AFP/Getty Images
Clinton is seen on television monitors in the media center at Hofstra. Justin Sullivan/Getty Images
Trump appears on the media center screens. Justin Sullivan/Getty Images