NEW YORK, NY - APRIL 26:  Republican presidential candidate Donald Trump  speaks to supporters and the media at Trump Towers following the conclusion of primaries Tuesday in northeastern states on April 26, 2016 in New York, New York. Trump again gained more delegates to move  him closer to the Republican presidential nomination.  (Photo by Spencer Platt/Getty Images)
NEW YORK, NY - APRIL 26: Republican presidential candidate Donald Trump speaks to supporters and the media at Trump Towers following the conclusion of primaries Tuesday in northeastern states on April 26, 2016 in New York, New York. Trump again gained more delegates to move him closer to the Republican presidential nomination. (Photo by Spencer Platt/Getty Images)
PHOTO: Spencer Platt/Getty Images
Now playing
01:50
Highlights from Super Tuesday 4 speeches
clinton trump woman card origwx bw_00001517.jpg
clinton trump woman card origwx bw_00001517.jpg
PHOTO: CNN
Now playing
00:47
Hillary Clinton and Donald Trump on the 'woman card'
PHOTO: Pool
Now playing
01:23
Super Tuesday in under 90 seconds
Now playing
00:10
This video is no longer available
Republican frontrunner Donald Trump speaks at Trump Tower in New York on April 26 after winning primaries in Pennsylvania, Maryland, Connecticut, Rhode Island and Delaware.
Republican frontrunner Donald Trump speaks at Trump Tower in New York on April 26 after winning primaries in Pennsylvania, Maryland, Connecticut, Rhode Island and Delaware.
PHOTO: KENA BETANCUR/AFP/Getty Images
Now playing
01:37
Donald Trump: I'm winning, why should I change?
PHOTO: Pool
Now playing
00:56
Clinton: Our campaign is about restoring confidence
van jones donald trump bizarre outcome sot ac_00002728.jpg
van jones donald trump bizarre outcome sot ac_00002728.jpg
PHOTO: CNN
Now playing
01:23
Van Jones: Donald Trump's sweep a 'bizarre outcome'
PHOTO: Pool
Now playing
01:05
Sanders: We have bigger lead over Trump than Clinton
PHOTO: cnn
Now playing
01:55
Ted Cruz: Trump 'likely to win some states'
PHOTO: CNN
Now playing
01:07
Trump: Hillary will be easier to beat than others
HAGERSTOWN, MD - APRIL 24:  Republican presidential candidate Donald Trump speaks while campaigning at the Hagerstown airport April 24, 2016 in Hagerstown, Maryland. Maryland holds their presidential primary on Tuesday, along with Delaware, Pennsylvania, Rhode Island and Connecticut.  (Photo by Win McNamee/Getty Images)
HAGERSTOWN, MD - APRIL 24: Republican presidential candidate Donald Trump speaks while campaigning at the Hagerstown airport April 24, 2016 in Hagerstown, Maryland. Maryland holds their presidential primary on Tuesday, along with Delaware, Pennsylvania, Rhode Island and Connecticut. (Photo by Win McNamee/Getty Images)
PHOTO: Win McNamee/Getty Images
Now playing
01:23
Polls shows voters warming towards Trump nomination
PHOTO: Getty Images/CNN Politics
Now playing
02:09
3 things to watch for on Super Tuesday 4
PHOTO: Win McNamee/Getty Images
Now playing
00:54
Jane Sanders: Bernie 'will not play role of spoiler'
Democratic presidential candidate former Secretary of State Hillary Clinton speaks during her primary night gathering on March 15, 2016 in West Palm Beach, Florida.
Democratic presidential candidate former Secretary of State Hillary Clinton speaks during her primary night gathering on March 15, 2016 in West Palm Beach, Florida.
PHOTO: Justin Sullivan/Getty Images
Now playing
02:20
Highlights from Super Tuesday 3 speeches
PHOTO: CNN
Now playing
02:04
Highlights from the Super Tuesday 2 speeches
best of super tuesday speeches wrap origwx nws_00004301.jpg
best of super tuesday speeches wrap origwx nws_00004301.jpg
Now playing
01:41
The best of the Super Tuesday speeches
super tuesday coverage two minutes origwx js_00005610.jpg
super tuesday coverage two minutes origwx js_00005610.jpg
Now playing
02:03
Six hours of Super Tuesday coverage in 2 minutes
Saturday Night Live Trump hand size orig vstan dlewis_00000000.jpg
Saturday Night Live Trump hand size orig vstan dlewis_00000000.jpg
PHOTO: Fox News / "Saturday Night Live" / Broadway Media
Now playing
01:03
'SNL' mocks Trump's hand-size feud
brokered convention possibility explained orig_00000000.jpg
brokered convention possibility explained orig_00000000.jpg
Now playing
01:35
What is a brokered convention?
Trump and Clinton
Trump and Clinton
PHOTO: CNN
Now playing
01:22
Two victory speeches, two different messages
Hillary Clinton Arizona win primary speech sot  _00001913.jpg
Hillary Clinton Arizona win primary speech sot _00001913.jpg
Now playing
00:56
Clinton: Contest between fundamentally different views
PHOTO: Getty Images
Now playing
02:19
Super Tuesday scenarios: Can Sanders slow Clinton?
HOUSTON, TX - FEBRUARY 25:  Republican presidential candidates  Florida Sen. Marco Rubio (R-FL), Donald Trump, and Texas Sen. Ted Cruz (R-TX) stand on stage for the Republican National Committee Presidential Primary Debate at the University of Houston
HOUSTON, TX - FEBRUARY 25: Republican presidential candidates Florida Sen. Marco Rubio (R-FL), Donald Trump, and Texas Sen. Ted Cruz (R-TX) stand on stage for the Republican National Committee Presidential Primary Debate at the University of Houston's Moores School of Music Opera House on February 25, 2016 in Houston, Texas. The candidates are meeting for the last Republican debate before the Super Tuesday primaries on March 1. (Photo by Joe Raedle/Getty Images)
PHOTO: Joe Raedle/Getty Images
Now playing
01:47
Super Tuesday scenarios: Can Donald Trump be stopped?
Bernie Sanders speaks during a campaign rally at West High School on March 21, 2016 in Salt Lake City, Utah.
Bernie Sanders speaks during a campaign rally at West High School on March 21, 2016 in Salt Lake City, Utah.
PHOTO: George Frey/Getty Images
Now playing
00:45
Bernie Sanders: We're gaining on Clinton
PHOTO: Nigel Parry for CNN
Now playing
00:53
CNN projection: Trump, Clinton win Arizona Primary
super tuesday march 15 in 2 minutes origwx js_00005623.jpg
super tuesday march 15 in 2 minutes origwx js_00005623.jpg
Now playing
01:57
Six hours of Super Tuesday #3 on CNN in 2 minutes
PHOTO: Nigel Parry for CNN
Now playing
01:00
Projection: Gov. John Kasich, Hillary Clinton win Ohio
@ 20: 48 - crowd cheers when CNN calls Ohio for Kasich
@ 20: 48 - crowd cheers when CNN calls Ohio for Kasich
PHOTO: Pool
Now playing
00:45
John Kasich: I will not take the low road
Donald Trump victory speech sot ac_00010508.jpg
Donald Trump victory speech sot ac_00010508.jpg
Now playing
01:17
Donald Trump: We have to bring our party together
CHARLOTTE, NC- MARCH 14:  Democratic presidential candidate former Secretary of State Hillary Clinton speaks during a Get Out the Vote event at Grady Cole Center on March 14, 2016 in Charlotte, North Carolina. Hillary Clinton is campaiging Illinois and North Carolina.  (Photo by Justin Sullivan/Getty Images)
CHARLOTTE, NC- MARCH 14: Democratic presidential candidate former Secretary of State Hillary Clinton speaks during a Get Out the Vote event at Grady Cole Center on March 14, 2016 in Charlotte, North Carolina. Hillary Clinton is campaiging Illinois and North Carolina. (Photo by Justin Sullivan/Getty Images)
PHOTO: Justin Sullivan/Getty Images
Now playing
00:48
Hillary Clinton: We're moving closer to the nomination
RENO, NV - FEBRUARY 23:  Republican presidential candidate Donald Trump speaks at a rally at the Nugget February 23, 2016 in Sparks, Nevada. The Nevada GOP caucus is tonight. (Photo by David Calvert/Getty Images)
RENO, NV - FEBRUARY 23: Republican presidential candidate Donald Trump speaks at a rally at the Nugget February 23, 2016 in Sparks, Nevada. The Nevada GOP caucus is tonight. (Photo by David Calvert/Getty Images)
PHOTO: David Calvert/Getty Images North America/Getty Images
Now playing
00:59
Donald Trump: Marco Rubio has a great future
PHOTO: CNN
Now playing
00:49
Marco Rubio: Not God's plan that I be president in 2016
Bernie Sanders phoenix arizona truth sot ac_00000119.jpg
Bernie Sanders phoenix arizona truth sot ac_00000119.jpg
Now playing
01:07
Bernie Sanders defiant despite primary losses
CNN Candidate Photography
John Kasich
ph: Nigel Parry
CNN Candidate Photography John Kasich ph: Nigel Parry
PHOTO: NIGEL PARRY for CNN
Now playing
03:25
John Kasich: We're proud of what we've done
PHOTO: Nigel Parry for CNN
Now playing
01:55
Projection: Donald Trump, Hillary Clinton win Florida
SHELBURNE, MA - MARCH 01: Voters check in before casting their ballots in the Shelburne Town Hall on March 01, 2016 in Shelburne, Massachusetts. Officials are expecting a record turnout of voters in Massachusetts, one of a dozen states holding Super Tuesday presidential primaries or caucuses. (Photo by Matthew Cavanaugh/Getty Images)
SHELBURNE, MA - MARCH 01: Voters check in before casting their ballots in the Shelburne Town Hall on March 01, 2016 in Shelburne, Massachusetts. Officials are expecting a record turnout of voters in Massachusetts, one of a dozen states holding Super Tuesday presidential primaries or caucuses. (Photo by Matthew Cavanaugh/Getty Images)
PHOTO: Matthew Cavanaugh/Getty Images
Now playing
00:56
High stakes for GOP on Super Tuesday
john kasich votes for president media avail sot nr_00005310.jpg
john kasich votes for president media avail sot nr_00005310.jpg
PHOTO: CNN
Now playing
00:54
John Kasich casts his vote in Ohio
The assassination of Julius Caesar (100 - 44 BC) at the Senate in Rome, 15th March 44 BC. (Photo by Archive Photos/Getty Images)
The assassination of Julius Caesar (100 - 44 BC) at the Senate in Rome, 15th March 44 BC. (Photo by Archive Photos/Getty Images)
PHOTO: Archive Photos/Getty Images
Now playing
01:54
Politicians, beware the Ides of March
PHOTO: CNN
Now playing
03:58
Sanders hopes to replicate Michigan magic in Ohio, Illinois
PHOTO: AFP/Getty Images
Now playing
01:44
Bernie Sanders wins case to allow 17-year-olds vote
PHOTO: KTVI
Now playing
02:38
Donald Trump on rallies: There's not much violence
PHOTO: AFP/Getty Images
Now playing
01:36
The fight for Mississippi and Michigan in 90 seconds
Democratic presidential candidate Sen. Bernie Sanders, I-Vt., speaks during a primary night rally in Essex Junction, Vt., Tuesday, March 1, 2016, on Super Tuesday. (AP Photo/Jacquelyn Martin)
Democratic presidential candidate Sen. Bernie Sanders, I-Vt., speaks during a primary night rally in Essex Junction, Vt., Tuesday, March 1, 2016, on Super Tuesday. (AP Photo/Jacquelyn Martin)
PHOTO: Jacquelyn Martin/AP/FILE
Now playing
02:10
Sanders: Michigan is proof of a political revolution
Hillary Clinton speech to supporters sot_00014514.jpg
Hillary Clinton speech to supporters sot_00014514.jpg
Now playing
01:47
Clinton: Campaigns should be about results, not insults
Now playing
00:53
Donald Trump talks about his steaks and wine
Republican presidential candidate Donald Trump speaks during a news conference at the Trump National Golf Club, Tuesday, March 8, 2016, in Jupiter, Fla. (AP Photo/Lynne Sladky)
Republican presidential candidate Donald Trump speaks during a news conference at the Trump National Golf Club, Tuesday, March 8, 2016, in Jupiter, Fla. (AP Photo/Lynne Sladky)
PHOTO: Lynne Sladky/AP
Now playing
01:26
Donald Trump: Voter turnout biggest story in politics
hillary clinton wins mississippi exit polls favor donald trump sot blitzer tsr_00001418.jpg
hillary clinton wins mississippi exit polls favor donald trump sot blitzer tsr_00001418.jpg
Now playing
00:55
Hillary Clinton wins Miss. as exit polls favor Trump

Story highlights

Trump sweeps GOP races; Clinton wins 4 races; Sanders takes Rhode Island

172 GOP delegates up for grabs; 384 pledged delegates at stake for Democrats

(CNN) —  

Donald Trump and Hillary Clinton scored huge victories Tuesday that bring them closer to a monumental duel for the White House in the fall.

Trump’s political strength was on display with a clean sweep of races in Maryland, Delaware, Pennsylvania, Connecticut and Rhode Island. Clinton delivered big wins in Maryland and Pennsylvania – the biggest prizes of the night – along with Delaware and Connecticut. Bernie Sanders picked up his sole victory of the night in Rhode Island.

The wins for Trump – following a massive victory last week in New York – move him significantly closer to the 1,237 delegates he needs to win the nomination outright and avoid a contested Republican convention. That historic prospect is now the only way rivals Texas Sen. Ted Cruz and Ohio Gov. John Kasich could stop Trump from becoming the GOP nominee.

“This to me was our biggest night,” Trump said in his victory speech. “I consider myself the presumptive nominee.”

CNN 2016 delegate tracker

Clinton’s big wins, meanwhile, help bolster her campaign’s argument that it is time for Sanders to make a decision to stop personal and political attacks on the former secretary of state that could weaken her ahead of a showdown in November with Republicans.

She climbed on stage to cheers in her election night headquarters in Philadelphia, the city that will host the Democratic National Convention this summer.

“With your help, we are going to come back to Philadelphia for the Democratic National Convention with the most votes and the most pledged delegates,” Clinton declared. “And we will unify our party to win this election and build an America where we can all rise together, an America where we lift each other up instead of tearing each other down.”

General election clash

Clinton foreshadowed the potential general election clash with Trump that could center on women voters.

“The other day, Mr. Trump accused me, of playing the, quote, woman card,” she said. “Well, if fighting for women’s health care and paid family leave and equal pay is playing the woman card, then deal me in.”

Trump struck back during his victory speech.

“I think the only card she has is the women’s card,” Trump said. “She has got nothing else going. Frankly, if Hillary Clinton were a man, I don’t think she would get 5% of the vote.”

He added: “And the beautiful thing is women don’t like her, ok?”

As of 2 a.m. ET, Trump picked up at least 142 delegates on Tuesday, bringing him to 988 compared to Cruz at 568 and Kasich at 152, according to CNN estimates. Clinton won at least 214 delegates, boosting her total to 2,168, which includes 1,666 pledged and 502 superdelegates. Sanders holds 1,401 delegates, including 1,359 pledged delegates and 42 superdelegates.

There were the first signs that Sanders may be about to embrace a change of tactics, despite vowing to take his campaign all the way to the Democratic convention in July.

In a statement issued after the results rolled in, Sanders insisted that he was in the race until “the last vote is cast.” But he added: “That is why this campaign is going to the Democratic National Convention in Philadelphia with as many delegates as possible to fight for a progressive party platform.”

While Sanders mentioned his desire to fight to influence the issues the party will fight on in November, he did not promise to push for a personal victory in the campaign — a significant difference.

Not backing down

Trump’s challengers may have one last chance to stop him from winning the nomination outright by beating him in the Indiana primary next week.

Cruz, speaking before polls closed – in a clear sign that he expected a bad night – slammed the media for what he said was a premature judgment that the general-election nominees would be Clinton and Trump. He branded them “New York liberals.”

But he predicted things would change next week.

“I’ve got good news for you tonight, this campaign moves back to more favorable terrain,” Cruz told a crowd in Indiana.

But Trump already has his sights on a general election — and will move further into a national campaign mode with a major foreign policy address in Washington on Wednesday, part of a process of putting a more conventional and professional foundation under his campaign — even as he insists that his wild rallies and volatile rhetoric which powered his political rise will continue.

Clinton banking on a big night

In the Democratic race, Clinton’s victories build on her resounding success in New York, which stunted Sanders’ momentum and left the senator – for all his fundraising muscle and large rallies – fending off calls from Clinton supporters to fold his campaign so that she can start exclusively targeting Republicans.

Bitter Pennsylvania Senate primary has Democratic establishment on edge

Sanders and Clinton were competing for 384 pledged delegates on Tuesday. Clinton went into the night leading Sanders by 253 pledged delegates, according to a CNN estimate, and dominated the count among superdelegates – party officials and activists who also have a convention vote.

At her victory speech, Clinton extended an olive branch to Sanders in an apparent effort to begin the process of unifying the Democratic Party behind her candidacy.

“I applaud Sen. Sanders and his millions of supporters for challenging us to get unaccountable money out of politics and putting greater emphasis to closing the gap of inequality,” she said. “I know together we will get that done.”

CNN’s Dan Merica contributed to this report