Drinking more coffee may help prevent alcohol-related cirrhosis

Updated 6:17 AM ET, Mon February 22, 2016

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Photos: Coffee's health history

It's thumbs up today, but the news on coffee has not always been positive. Take a look at the arguments for and against coffee through the centuries.

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Legend has it that coffee was discovered by Kaldi, an Ethiopian goatherd, after he caught his suddenly frisky goats eating glossy green leaves and red berries and then tried it for himself.

Photos: Coffee's health history

1500s headline: Coffee makes you frisky – Legend has it that coffee was discovered by Kaldi, an Ethiopian goatherd, after he caught his suddenly frisky goats eating glossy green leaves and red berries and then tried it for himself.

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But it was the Arabs who started coffeehouses, and that's where coffee got its first black mark. Patrons of coffeehouses were said to be more likely to gamble and engage in "criminally unorthodox sexual situations," according to author <a href="https://www.washington.edu/uwpress/search/books/HATCOF.html" target="_blank">Ralph Hattox</a>.

Photos: Coffee's health history

1500s headline: Coffee leads to illegal sex – But it was the Arabs who started coffeehouses, and that's where coffee got its first black mark. Patrons of coffeehouses were said to be more likely to gamble and engage in "criminally unorthodox sexual situations," according to author Ralph Hattox.

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As the popularity of coffee grew and spread, the medical community began to extol its benefits. It was especially popular in England as a cure for alcoholism, one of the biggest medical problems of the time.

Photos: Coffee's health history

1600s headline: Coffee cures alcoholism – As the popularity of coffee grew and spread, the medical community began to extol its benefits. It was especially popular in England as a cure for alcoholism, one of the biggest medical problems of the time.

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This 1652 ad by London coffee shop owner Pasqua Rosée popularized coffee's healthy status, claiming that coffee could aid digestion, prevent and cure gout and scurvy, help coughs, headaches and stomachaches, and even prevent miscarriages.

Photos: Coffee's health history

1600s headline: Coffee cures all? – This 1652 ad by London coffee shop owner Pasqua Rosée popularized coffee's healthy status, claiming that coffee could aid digestion, prevent and cure gout and scurvy, help coughs, headaches and stomachaches, and even prevent miscarriages.

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By 1730, tea had replaced coffee in London as the daily drink of choice. That preference continued in the colonies until 1773, when the famous Boston Tea Party made it unpatriotic to drink tea. Coffee houses popped up everywhere, and the marvelous stimulant qualities of the brew were said to contribute to the ability of the colonists to work longer hours.

Photos: Coffee's health history

1700s headline: Coffee helps you work longer – By 1730, tea had replaced coffee in London as the daily drink of choice. That preference continued in the colonies until 1773, when the famous Boston Tea Party made it unpatriotic to drink tea. Coffee houses popped up everywhere, and the marvelous stimulant qualities of the brew were said to contribute to the ability of the colonists to work longer hours.

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In the mid-1800s, America was at war with itself, and one side effect was that coffee supplies ran short. Enter toasted grain-based beverage substitutes such as Kellogg's "Caramel Coffee" and C.W. Post's "Postum" (still manufactured), which advertised with anti-coffee tirades to boost sales.

Photos: Coffee's health history

1800s headline: Coffee shortage – In the mid-1800s, America was at war with itself, and one side effect was that coffee supplies ran short. Enter toasted grain-based beverage substitutes such as Kellogg's "Caramel Coffee" and C.W. Post's "Postum" (still manufactured), which advertised with anti-coffee tirades to boost sales.

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Postum's ads <a href="https://books.google.com/books?id=Hy0YIUYybOsC&pg=PA131&lpg=PA131&dq=19th-century+inventor+C.+W.+Post+on+coffee+bad+for+you&source=bl&ots=g2hh-151v4&sig=puGib3_29lDVz6F027IKRlnTNNY&hl=en&sa=X&ved=0CCkQ6AEwAmoVChMIiY25raukxwIVSVw-Ch14BwLK#v=onepage&q&f=false" target="_blank">against coffee</a> were especially negative, claiming that coffee was as bad as morphine, cocaine, nicotine or strychnine and could cause blindness.

Photos: Coffee's health history

1800s headline: Coffee will make you go blind – Postum's ads against coffee were especially negative, claiming that coffee was as bad as morphine, cocaine, nicotine or strychnine and could cause blindness.

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Medical concerns and negative public beliefs about the benefits of coffee rose in the early 1900s. Good Housekeeping magazine <a href="https://books.google.com/books?id=ve5AAQAAMAAJ&pg=PA113#v=onepage&q&f=false" target="_blank">wrote about how coffee stunts growth</a>. <br />

Photos: Coffee's health history

1916 headline: Coffee stunts your growth – Medical concerns and negative public beliefs about the benefits of coffee rose in the early 1900s. Good Housekeeping magazine wrote about how coffee stunts growth.

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In a 1927 Science magazine article, 80,000 elementary and junior high kids were asked about their coffee drinking habits. Researchers found the "startling" fact that most of them drank more than a cup of coffee a day, which was compared with scholarship with mostly negative results.

Photos: Coffee's health history

1927 headline: Coffee will give you bad grades, kids – In a 1927 Science magazine article, 80,000 elementary and junior high kids were asked about their coffee drinking habits. Researchers found the "startling" fact that most of them drank more than a cup of coffee a day, which was compared with scholarship with mostly negative results.

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In 1978, the same year Baseball Hall of Famer Joe DiMaggio began selling Mr. Coffee on TV, a <a href="http://www.ncbi.nlm.nih.gov/pubmed/339084" target="_blank">New England Journal of Medicine</a> study found a short-term rise in blood pressure after three cups of coffee. <br /><br />And a<a href="http://www.nejm.org/doi/full/10.1056/NEJM197307122890203#t=articleTop" target="_blank"> 1973 study</a> found that drinking one to five cups of coffee a day increased risk of heart attacks by 60%, while drinking six or more cups a day doubled that risk to 120%.

Photos: Coffee's health history

1970s headline: Coffee is as serious as a heart attack – In 1978, the same year Baseball Hall of Famer Joe DiMaggio began selling Mr. Coffee on TV, a New England Journal of Medicine study found a short-term rise in blood pressure after three cups of coffee.

And a 1973 study found that drinking one to five cups of coffee a day increased risk of heart attacks by 60%, while drinking six or more cups a day doubled that risk to 120%.

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Now begins the era of the meta-analysis, in which researchers look at hundreds of studies and apply scientific principles to find those which do the best job of randomizing and controlling for compounding factors, such as smoking. The results for coffee: mostly good.<br /><br />But first, a couple of negatives: A <a href="http://www.ncbi.nlm.nih.gov/pubmed/11369742" target="_blank">2001 study</a> found a 20% increase in risk of urinary tract cancer for coffee drinkers but not tea drinkers. That finding was repeated in a <a href="http://www.nature.com/articles/srep09051" target="_blank">2015 meta-analysis</a>. So if this is a risk factor in your family history, you might want to switch to tea.<br /><br />And a 2010 <a href="http://www.ncbi.nlm.nih.gov/pubmed/19362749" target="_blank">meta-analysis</a> found a correlation between coffee consumption and lung disease, but the study found it impossible to completely eliminate the confounding effects of smoking.

Photos: Coffee's health history

2000 era headline: Time for meta-analysis – Now begins the era of the meta-analysis, in which researchers look at hundreds of studies and apply scientific principles to find those which do the best job of randomizing and controlling for compounding factors, such as smoking. The results for coffee: mostly good.

But first, a couple of negatives: A 2001 study found a 20% increase in risk of urinary tract cancer for coffee drinkers but not tea drinkers. That finding was repeated in a 2015 meta-analysis. So if this is a risk factor in your family history, you might want to switch to tea.

And a 2010 meta-analysis found a correlation between coffee consumption and lung disease, but the study found it impossible to completely eliminate the confounding effects of smoking.

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A<a href="http://aje.oxfordjournals.org/content/174/9/993.long" target="_blank"> meta-analysis</a> of 11 studies on the link between stroke risk and coffee consumption between 1966 and 2011, with nearly a half a million participants, found no negative connection. And a 2012 <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3526718/" target="_blank">meta-analysis</a> of studies between 2001 and 2011 found four or more cups a day had a preventative effect on your risk for stroke. <br /><br />This <a href="http://www.sciencedirect.com/science/article/pii/S0016508507005689" target="_blank">meta-analysis </a>showed that drinking two cups of black coffee a day could reduce the risk of liver cancer by 43%. Those findings were <a href="http://www.sciencedirect.com/science/article/pii/S1542356513006095" target="_blank">replicated</a> in 2013 in two <a href="http://www.biomedcentral.com/1471-230X/13/34" target="_blank">other studies. </a><br /><br />As for prostate cancer, a <a href="http://www.ncbi.nlm.nih.gov/pubmed/21586702" target="_blank">2011 study</a> followed nearly 59,000 men from 1986 to 2006 and found drinking coffee to be highly associated with lower risk for the lethal form of the disease.

Photos: Coffee's health history

2007-2013 headlines: Coffee reduces risk of stroke and some cancers – A meta-analysis of 11 studies on the link between stroke risk and coffee consumption between 1966 and 2011, with nearly a half a million participants, found no negative connection. And a 2012 meta-analysis of studies between 2001 and 2011 found four or more cups a day had a preventative effect on your risk for stroke.

This meta-analysis showed that drinking two cups of black coffee a day could reduce the risk of liver cancer by 43%. Those findings were replicated in 2013 in two other studies.

As for prostate cancer, a 2011 study followed nearly 59,000 men from 1986 to 2006 and found drinking coffee to be highly associated with lower risk for the lethal form of the disease.

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A similar analysis of studies on<a href="http://circheartfailure.ahajournals.org/content/5/4/401.long" target="_blank"> heart failure</a> found four cups a day provided the lowest risk for heart failure, and you had to drink a whopping 10 cups a day to get a bad association.<br /><br />And overall heart disease? A <a href="http://circ.ahajournals.org/content/129/6/643.long" target="_blank">meta-analysis</a> of 36 studies with more than 1.2 million participants found that moderate coffee drinking seemed to be associated with a low risk for heart disease; plus, there wasn't a higher risk among those who drank more than five cups a day.

Photos: Coffee's health history

A similar analysis of studies on heart failure found four cups a day provided the lowest risk for heart failure, and you had to drink a whopping 10 cups a day to get a bad association.

And overall heart disease? A meta-analysis of 36 studies with more than 1.2 million participants found that moderate coffee drinking seemed to be associated with a low risk for heart disease; plus, there wasn't a higher risk among those who drank more than five cups a day.

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How about coffee's effects on your overall risk of death? One 2013 analysis of <a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9205090&fileId=S0007114513003814" target="_blank">20 studies</a>, and another that included <a href="http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9627964&fileId=S1368980014001438" target="_blank">17 studies</a>, both of which included more than a million people, found that drinking coffee reduced your total mortality risk slightly.<br /><br />And as a sign of the times, in 2015, the<a href="http://health.gov/dietaryguidelines/2015-scientific-report/PDFs/Scientific-Report-of-the-2015-Dietary-Guidelines-Advisory-Committee.pdf" target="_blank"> US Department of Agriculture</a> agreed that "coffee can be incorporated into a healthy lifestyle," especially if you stay within three and five cups a day (a maximum of 400 milligrams of caffeine) and avoid fattening cream and sugar. You can read its analysis of data <a href="http://health.gov/dietaryguidelines/2015-scientific-report/10-chapter-5/d5-4.asp" target="_blank">here.</a>

Photos: Coffee's health history

2015 headline: Coffee is practically a health food – How about coffee's effects on your overall risk of death? One 2013 analysis of 20 studies, and another that included 17 studies, both of which included more than a million people, found that drinking coffee reduced your total mortality risk slightly.

And as a sign of the times, in 2015, the US Department of Agriculture agreed that "coffee can be incorporated into a healthy lifestyle," especially if you stay within three and five cups a day (a maximum of 400 milligrams of caffeine) and avoid fattening cream and sugar. You can read its analysis of data here.

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Story highlights

In eight out of nine studies examined, researchers found coffee consumption may have helped prevent cirrhosis
Alcoholism is the second most common cause of cirrhosis In the U.S.

(CNN)Make that black coffee order a double.

Upping your coffee intake may help reduce your chances of developing alcohol-related cirrhosis, according to a review done by the journal Alimentary Pharmacology and Therapeutics of multiple existing studies.

Drinking just two more cups of coffee every day may lower the risk of developing the liver condition by 44%, according to researchers who analyzed nine studies that examined the relationship between coffee consumption and the risk of cirrhosis.

READ: Is chocolate good or bad for health?

More than 430,000 participants were a part of the nine studies. The duration of these studies varied, but the longest one lasted about 20 years. In eight of the nine studies examined, researchers found increasing coffee consumption by two cups per day was "associated with a statistically significant reduction in the risk of cirrhosis." The review, published January 25, is the first meta-analysis to show the potential protective properties of coffee.

Dr. Oliver Kennedy, who conducted the research as part of a team at Southampton University in the United Kingdom, told CNN the team combined the data of these existing studies to calculate a more precise relationship between coffee and the risk of cirrhosis.