"The policy persistently pursued by the U.S. to stifle (North Korea), groundlessly stirring up bad blood towards it would only harden its will and resolution," a statement attributed to North Korea's Foreign Ministry said.
On Friday, the United States hit North Korea with the new sanctions after the FBI said North Korea was behind last month's computer hack at Sony.
The White House said a new executive order targets leaders in North Korea's government, preventing them from accessing property and entering the United States. The isolated nuclear regime, which has denied involvement in the Sony hack, was already subject to a strict set of U.S. economic restrictions.
The FBI has maintained North Korea was behind the broad computer breach at Sony, though some technology experts say others could be involved -- such as former employees of the studio.
On Friday, officials said the new set of sanctions was further indication of their confidence in North Korea's culpability, and said that private tech firms aren't privy to the intelligence proving Pyongyang's guilt.
Obama signed the executive order putting the new sanctions in place on the second-to-last day of his winter vacation in Hawaii. Before his vacation began in mid-December Obama said North Korea was responsible for the attack and the United States was preparing a response. The White House said Friday's announcement reflected the beginning of that response.
"The order is not targeted at the people of North Korea, but rather is aimed at the government of North Korea and its activities that threaten the United States and others," Obama wrote in a letter to House Speaker John Boehner.
The country poses a "continuing threat to the national security, foreign policy and economy of the United States," Obama wrote.
Among the agencies targeted by the new sanctions Friday was the Reconnaissance General Bureau, an intelligence agency the United States said was responsible for "major cyberoperations" in North Korea.
The new sanctions also target officials at North Korea's Mining Development Trading Corporation, which the United States says is responsible for the country's arms dealing and weapons export business.
Seven officials who represent North Korea's arms dealing trade in Africa, Iran, Russia and Syria were designated by the U.S. Treasury as subject to the new economic sanctions.
U.S. administration officials said the individuals targeted by Friday's sanctions are not thought to be responsible for the Sony hack. But in exposing their names and positions as North Korean arms dealers, the United States hopes to stymie their business prospects.
U.S. officials said they didn't know whether the 10 North Korean officials listed by the Treasury Department held any assets in U.S. institutions.
Treasury Secretary Jack Lew said the sanctions were meant to "isolate key North Korean entities and disrupt the activities of close to a dozen critical North Korean operatives."
"We will continue to use this broad and powerful tool to expose the activities of North Korean government officials and entities," Lew said.
Speaking to CNN late last month, Obama said the United States would respond to the Sony hacking "proportionately," without specifying what actions his government might take to punish Kim Jong Un's government.
White House Press Secretary Josh Earnest said on Friday, "Today's actions are the first aspect of our response."
That seemed to indicate the widespread Internet outages reported in North Korea last month were not a retaliatory response to the Sony hack, though administration officials would not confirm the blackout came at the hands of the United States.
"There are many possible explanations for (North Korea's) Internet outage, including the possibility that they had ended up doing it to themselves," one U.S. official said.