Jennifer Palmieri, Obama's communications director, left in spring 2015. She now serves as the director of communications for Hillary Clinton's 2016 presidential campaign.
Dan Pfeiffer, one of Obama's chief strategists and closest advisers, departed from the White House in early March, officials confirmed.
Marilyn Tavenner, the Centers for Medicare and Medicaid Services' top administrator who was involved in the roll-out of Obamacare, announced in an email to staff that she was resigning at the end of February 2015.
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Secret Service Director Julia Pierson resigned in October 2014 after multiple security breaches involving the President. The firestorm began after an intruder scaled the fence and entered the White House on September 19, 2014.
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Gen. David Petraeus stepped down as director of the CIA on November 9, 2012, after an FBI investigation confirmed he was having an affair with his biographer, Paula Broadwell. He served the position for a little over a year.
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Gen. Eric Shinseki resigned in May 2014 after it was revealed that Veterans Affairs administrators had conspired to cover up wait lists that were months long, leaving sick and dying veterans waiting for care.
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Kathleen Sebelius resigned as secretary of Health and Human Services in April 2014 after months of backlash against her role in the faulty roll-out of Healthcare.gov.
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Shirley Sherrod, a former official with the Department of Agriculture, was forced to resign from her position in 2010 after a conservative blogger published a video of her questioning whether to help a white man losing his farm since " so many black people lost their farm land" before him. When it was discovered that the video was taken out of context, the USDA offered her another job, which she declined.
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In June 2010, Obama relieved Gen. Stanley McChrystal from his post as commander of U.S. forces in Afghanistan after disparaging comments McChrystal made against the administration in Rolling Stone magazine.
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Three months after Tareq and Michaele Salahi crashed a state dinner in November 2009, Desiree Rogers stepped down as White House social secretary.
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Suzanne Barr, a senior Obama administration political appointee and longtime aide to Homeland Security Secretary Janet Napolitano, resigned September 1, 2012, amid allegations of inappropriate sexual behavior lodged by at least three Immigration and Customs Enforcement employees.