Updated 12:55 PM ET, Wed May 28, 2014
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Serena Williams' bid to claim a record-equaling 18th women's singles grand slam title came to an abrupt end in Paris after she was knocked out in the second round 6-2 6-2 by Spain's Garbine Muguruza. Matthias Hangst/Getty Images
Williams congratulates her conqueror Garbine Muguruza, the Spaniard later explaining what the defending champion had told her: "She said that if I continue playing like this, I can win the tournament. I said, 'I will try, I will try.'" Matthew Stockman/Getty Images
Muguruza's victory marked Serena's worst performance in a grand slam, as she'd never won less than five games previously. With Li Na's exit on Tuesday, it is the first time neither of the top two women's seeds have made it to the third round of a grand slam in the Open era. Matthew Stockman/Getty Images
Muguruza will now face the unseeded Anna Schmiedlova, who also took a Williams scalp on Wednesday. The Slovakian beat 2002 finalist Venus 2-6 6-3 6-4 and denied a mouth-watering clash between the Williams sisters in round three. Matthias Hangst/Getty Images
Venus has been hindered by debilitating autoimmune disease Sjogren's Syndrome in recent years, and is currently ranked 29th in the world. Only once in her last seven outings at Roland Garros has she made it past round three. Matthias Hangst/Getty Images
There were no such shocks at the top of the men's draw on Wednesday. Roger Federer, a 17-time grand slam champion and the No. 4 seed, eased through to round three with a comfortable straight sets win over Diego Sebastian Schwartzman from Argentina. Matthias Hangst/Getty Images
No. 2 seed Novak Djokovic was in typically ebullient mood during his routine victory over France's Jeremy Chardy. The Serbian is searching for a first French Open title to complete his own personal grand slam and will now face Marin Cilic in round three. Matthias Hangst/Getty Images