Rita Colwell has been studying cholera for half a century
Her team discovered an innovative way to control the disease in Bangladesh
Research has shown cholera is related to global warming, she says
Clean water availability is not "one-size-fits-all"
Cholera, a deadly diarrheal disease, has been rare in the United States since the early 1900s, but in the developing world, where access to clean drinking water is more difficult, it is still a serious problem.
Dr. Rita Colwell has studied cholera for nearly 50 years, and has written more than 700 publications and received at least 40 honorary degrees. The former director of the National Science Foundation and former president of the American Association for the Advancement of Science, Colwell is currently a distinguished professor at both the University of Maryland, College Park and Johns Hopkins University’s Bloomberg School of Public Health.
CNN spoke with Colwell about her research and how she and her team helped develop an incredibly simple method to help the people of rural Bangladesh have cleaner, safer drinking water. The following is an edited portion of that interview.
CNN: Tell me about cholera.
Colwell: Cholera is … transmitted by water. The bacteria that causes the disease … (naturally occurs) in the aquatic environment. That’s a discovery that my laboratory made some 25 to 30 years ago. When ingested, it attaches to the intestine and a toxin is most frequently produced. The result is severe vomiting, diarrhea and if a person doesn’t have their fluid replenished, dehydration and eventually death (results).
CNN: Is there an antibiotic for cholera?
Colwell: You can take an antibiotic. It’s generally susceptible to tetracycline, a broad-spectrum antibiotic, and other antibiotics. There’s been a discovery some years ago of what’s called oral rehydration therapy, ORT, whereby a mixture in water of table salt, bicarbonate of soda and table sugar is mixed in appropriate concentration and sipped. This replenishes the fluid loss and is very effective in treating cholera.
CNN: That’s interesting that it doesn’t seem people die from the bacteria attacking their systems, but rather the dehydration effects.
Colwell: That’s predominantly the case. The toxin can have other effects but mainly it’s the sodium-potassium transport mechanism that gets interfered with. Bangladesh has two major epidemics every year: spring, which is right about now, and fall: September, October, November. This occurs year after year with almost no exception due to the fact that, as we have shown, the bacteria are associated with plankton. As the plankton become abundant, they bloom in the spring and fall, after which the cholera bacteria become abundant in the water and the disease occurs.
CNN: Are cholera outbreaks connected to global warming?
Colwell: Temperature is a major regulator of the abundance of the cholera bacteria. The study that was carried out by Carla Pruzzo in Italy, with which we collaborated, was an analysis of plankton samples that had been stored for the past 40 years at a marine laboratory in England. They’d been collecting samples every year for 40 years and so we analyzed the samples, and what Dr. Pruzzo and our team found was that as the water temperature is increasing, the numbers of vibrios (small, comma-shaped bacteria) and the number of cases of diseases caused by vibrio, namely cholera, have been increasing. It has been directly related to the warming of the sea temperature.
CNN: Can you describe the method you developed in Bangladesh to control cholera?
Colwell: Having done an enormous amount of research showing the ecology of the cholera bacterium, (we found) it was definitely tied to plankton. The cholera bacteria is part of their natural flora. It occurred to us that by simple filtration to remove the plankton, we would filter about 99% of the bacteria, leaving just a few suspended in the water. So then, we hypothesized, we could reduce cholera significantly by educating women who collect water for their household to use cloth filtration.
We found that sari cloth that comprised the dresses that women wear, if folded about four times, gave a very nice mesh filter, with small enough pore size to trap plankton. A three-year study was funded by the National Institutes of Health and Nursing Institute that involved about 50 villages and over 150,000 people, and sure enough, by having women filter their water collected from the ponds and rivers every day, we showed about a 50% decrease in cholera. A very simple step, and very important.
CNN: How did you get the message out to everyone that they should be doing this?
Colwell: We worked with the women in the villages and we trained them, essentially as extension agents … to go to the villages every week with a meeting for the women of the village to explain to them why it’s good to filter, how to filter, and the difference it would make to the health of their children. So with this constant reinforcement, we found that indeed, they did filter because they found that their children didn’t get sick. And that, of course, was a big incentive. The project ended about six years ago, but we went back to see if they were still filtering, and we found 75% of them were.
CNN: So, do you think that clean water is the key to controlling waterborne diseases like cholera? Or, do you think it’s getting people the education about better sanitation?