Since "Dawson's Creek," James Van Der Beek has made fans laugh with a slew of "Funny or Die" sketches and the hilarious Van Der Memes Tumblr. ABC recently pulled "Don't Trust the B---- in Apartment 23," on which he plays a fictional version of himself. He'll next guest-star in an episode of "How I Met Your Mother." Imeh Akpanudosen/Getty Images
After Katie Holmes won fans over as Joey Potter, she went on to appear in films like "Batman Begins" and "The Romantics." She has played Jackie Kennedy in the miniseries "The Kennedys" and recently appeared in "Dead Accounts" on Broadway. She started a clothing line called Holmes & Yang in 2008, and in 2012 her split with Tom Cruise made headlines. WB/Andrew H. Walker/Getty Images
Joshua Jackson appeared in several films before starring as Peter Bishop on Fox's "Fringe" for five seasons. The drama's series finale aired on January 18, leaving "Apartment 23" fans crossing their fingers for a Pacey-Dawson reunion. WB/Alberto E. Rodriguez/Getty Images
Post Jen Lindley, Michelle Williams has starred in films like "Brokeback Mountain," "Blue Valentine" and "My Week with Marilyn," all of which have earned the actress Oscar nods. She'll next appear as Glinda in "Oz the Great and Powerful."
Kerr Smith said goodbye to Jack McPhee and hello to characters like "Charmed's" Kyle Brody and "Life Unexpected's" Ryan Thomas. He'll next appear in Carl T. Evans' "Criticized." WB/Jason Kempin/Getty Images
After playing Andie McPhee on the WB drama, Meredith Monroe guest-starred on a number of TV shows and appeared in films such as "Nowhere to Hide" and "Transformers: Dark of the Moon." WB/Joe Kohen/Getty Images
Busy Philipps, who joined the cast as Audrey Liddell in 2001, guest-starred on a recent episode of Van Der Beek's "Apartment 23" as a fictional version of herself. She has appeared in films like "White Chicks" and "I Don't Know How She Does It," as well as TV shows like "Love, Inc." and "ER." She currently appears on "Cougar Town." WB/Kevork Djansezian/Getty Images
Mary Beth Peil appeared in films such as "The Stepford Wives" and "Flags of Our Fathers" after playing Grams on "Dawson's Creek." She eventually returned to TV in the role of Jackie Florrick on CBS' "The Good Wife." WB/Michael N. Todaro/Getty Images