(CNN) -- Richard C. Holbrooke, the high-octane diplomat who spearheaded the end of the Bosnian war and most recently served as the Obama administration's point man in the volatile Afghan-Pakistani war zone, died Monday at George Washington University Hospital in Washington. Following are reactions to his death:
Secretary of State Hillary Clinton
"Tonight America has lost one of its fiercest champions and most dedicated public servants. Richard Holbrooke served the country he loved for nearly half a century, representing the United States in far-flung war-zones and high-level peace talks, always with distinctive brilliance and unmatched determination. He was one of a kind -- a true statesman -- and that makes his passing all the more painful. From his early days in Vietnam to his historic role bringing peace to the Balkans to his last mission in Afghanistan and Pakistan, Richard helped shape our history, manage our perilous present, and secure our future. He was the consummate diplomat, able to stare down dictators and stand up for America's interests and values even under the most difficult circumstances. He served at every level of the Foreign Service and beyond, helping mentor generations of talented officers and future ambassadors. Few people have ever left a larger mark on the State Department or our country. From Southeast Asia to post-Cold War Europe and around the globe, people have a better chance of a peaceful future because of Richard's lifetime of service."
President Barack Obama
"For nearly 50 years, Richard served the country he loved with honor and distinction. He worked as a young foreign service officer during the Vietnam War and then supported the Paris peace talks which ended that war. As a young Assistant Secretary of State for East Asian and Pacific Affairs, he helped normalize relations with China. As U.S. Ambassador to Germany, he helped Europe emerge from a long Cold War and encouraged NATO to welcome new members. As Assistant Secretary of State for European and Canadian Affairs, he was the tireless chief architect of the Dayton Accords that ended the war in Bosnia 15 years ago this week, saving countless lives. As Ambassador to the United Nations, Richard helped break a political impasse and strengthen our nation's relationship with the UN and elevated the cause of AIDS and Africa on the international agenda. And throughout his life, as a child of refugees, he devoted himself to the plight of people displaced around the world."
Vice President Joe Biden, former chairman of the Senate Foreign Relations Committee
"Today, I lost a great friend and America lost one of its greatest warriors for peace. Richard Holbrooke was a larger than life figure, who through his brilliance, determination and sheer force of will helped bend the curve of history in the direction of progress. He touched so many lives and helped save countless more. He was a tireless negotiator, a relentless advocate for American interests, and the most talented diplomat we've had in a generation."
Commander Gen. David Petraeus, commanding general of U.S. Forces in Afghanistan
"This is a tragic loss for our country, this region, and our world," said Gen. Petraeus. "Richard Holbrooke was a true titan in the diplomatic arena and a central figure in the effort in Afghanistan and Pakistan. It was a privilege to work closely with Ambassador Holbrooke when I was at CENTCOM and then as the commander here in Afghanistan. Indeed, it was with considerable pride that we called him our 'diplomatic wingman.' He was, in short, a tremendous diplomatic partner, a great American, and a good friend. Our thoughts are with Kati and his family."
Former President Bill Clinton
"In a lifetime of passionate, brilliant service on the front lines of war and peace, freedom and oppression, Richard Holbrooke saved lives, secured peace, and restored hope for countless people around the world. Tomorrow marks the 15-year anniversary of the signing of the Dayton Accords - the agreement Dick negotiated which stopped the killings in Bosnia and paved a path to peace in the Balkans that endures today. He was central to our efforts to limit ethnic cleansing in Kosovo and pave the way for its independence, and he found a way to break the stalemate in talks in Cyprus. I was proud to nominate him as the United States' ambassador to the United Nations, where he helped equip the UN to meet the challenges of our 21st Century world. For the last two years, he worked hard to counter terrorism and to build a secure, democratic future for Afghanistan and Pakistan. Our nation is safer, and our world stronger, because of the work he did. I will miss my friend very much."
Madeleine Albright, former Secretary of State
"With the death of Richard Holbrooke we have all lost a tremendous and devoted advocate for peace, diplomacy and human rights. I had the honor and privilege of working with Richard through many international crises over several decades, most particularly the wars in Bosnia and Kosovo. He could always be counted on for his imagination, dedication and forcefulness. He was a tireless defender of democracy and freedom, and continued working on these issues in Afghanistan and Pakistan until his final days. Above all, he loved our country. His death is a blow to American diplomacy and the goals to which he dedicated his life. All of his friends will miss his energy and determination. I am deeply saddened, and my thoughts and prayers are with his wife Kati and his entire family."
Samuel Berger, former National Security Advisor
"I am deeply saddened by the death of Richard Holbrooke-- a remarkable public servant and a dedicated force for good. Richard was an unrelenting advocate for peace, a superb diplomat and a dear friend. My thoughts and prayers are with his family."
Pakistani President Asif Ali Zardari
"Pakistan has a lost a friend. He was an accomplished and experienced diplomat who quickly gained the confidence of interlocutors. He was a key player in international diplomacy to bring peace to Bosnia and in confronting militancy in our part of the world. His services will be long
remembered. The best tribute to him is to reiterate our resolve to root out extremism and usher in peace. My thoughts are with his wife and family. May his soul rest in eternal peace."
Hussain Haqqani, Pakistani ambassador to the United States:
"In Richard Holbrooke's passing the world has lost a great diplomat while I have lost a personal friend and professional role model. Amb. Holbrooke showed great compassion for the people of Pakistan and was a strong supporter of Pakistan's progress and security as a modern Muslim democratic country. His attitude towards diplomacy was reflected in his response to my question at our breakfast on Thursday about how long he planned to keep working. He said 'As long as I can make a difference.' His greatest asset was his ability to be a personal friend and diplomatic interlocutor at the same time."
Rep. Ileana Ros-Lehtinen of Florida, ranking Republican on the House Foreign Affairs Committee
"Richard Holbrooke has been a dynamic force in American diplomacy for more than five decades. His stellar service is deeply appreciated and held in the highest esteem."
Sen. John Kerry, chairman of the Senate Foreign Relations Committee
"This awful news is almost incomprehensible, not least of all because I cannot imagine Richard Holbrooke in anything but a state of perpetual motion. He was always working. He was always a man on a mission, the toughest mission, and that mission was waging peace through tough as nails, never quit diplomacy - and Richard's life's work saved tens of thousands of lives. We loved his energy, we loved his resolve -- that's who Richard was, and he died giving everything he had to one last difficult mission for the country he loved. It is almost a bittersweet bookend that a career of public diplomacy that began trying to save a war gone wrong, now ends with a valiant effort to keep another war from going wrong."
Sen. Joe Lieberman, I-Connecticut
"Richard Holbrooke was a colossus of American diplomacy. From Vietnam to the Balkans and now Afghanistan and Pakistan, the history of our nation's foreign policy over the last forty years is inseparable from Richard's own remarkable and courageous life -- which was spent, both inside and outside government, in the distinguished service of the country he loved and in pursuit of the most noble ideals for which it stands. Richard Holbrooke has left the world far too soon, but he leaves it a far better place through his achievements."
Samuel Worthington, President of InterAction, an alliance of U.S.-based international non-governmental organizations
"The U.S. NGO community wishes to extend our sincere condolences to Ambassador Richard Holbrooke's family and to all of his colleagues at the State Department on his untimely passing. Ambassador Holbrooke was a longtime friend of the NGO community and his death was a shock to us all. He served on many non-profit boards and was deeply committed to the humanitarian values that guided the NGO response to the Pakistani floods. Ambassador Holbrooke's passing is a great loss to his colleagues, friends, family and to our country. He was a gifted diplomat, whose work over half a century made a difference in the lives of so many people, whether helping to end wars or dealing with their aftermath. His mark on history will be forever felt."