Burrowing rodents of the genus Cynomys, like this prairie dog, can harbor fleas infected with Yersinia pestis, the bacterium that causes plague.  

PLAGUE

WHAT IS IT?
The causative agent of plague, Yersinia pestis, is found in rodents and their fleas.

HOW DOES IT SPREAD?
The plague bacterium could be disseminated by aerosol, resulting in the pneumonic form with the potential for secondary spread of cases through respiratory droplets of those infected.

SYMPTOMS:
Within one to six days after exposure, the first signs of illness are fever, headache and weakness, which can lead to shock and death within two to four days.

TREATMENT:
Antibiotics within 24 hours of first symptoms.

Source: CDC; American Medical Association