In the early stages, you may have no osteomalacia symptoms, although signs of osteomalacia may be apparent on X-ray pictures or other diagnostic tests. As osteomalacia worsens, you may experience bone pain and muscle weakness.

Bone pain
The dull, aching pain associated with osteomalacia most commonly affects the:

• Lower spine
• Pelvis
• Legs

Muscle weakness
Osteomalacia may result in:

• Decreased muscle tone
• Weakness in your arms and legs
• Reduced ability to get around
• A waddling gait

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Your body uses calcium and phosphate to build strong bones. Osteomalacia may occur if you don't get enough of these minerals in your diet or if your body doesn't absorb them properly. These problems may be caused by:

• Insufficient exposure to sunlight. Sunlight produces vitamin D in your skin. Your body needs vitamin D to process calcium. Osteomalacia can develop in people who spend little time in sunlight, wear very strong sunscreen, remain covered while outside, or live in areas where sunlight hours are short or the air is smoggy.
• Insufficient vitamin D intake. A diet low in vitamin D is the most common cause of osteomalacia worldwide. However, it's a less common cause in the United States because many foods, such as milk and cereals, are fortified with vitamin D.
• Certain surgeries. Removing part or all of your stomach (gastrectomy) can cause osteomalacia because your stomach breaks down foods to release vitamin D and other minerals, which are absorbed in your intestines. Surgery to remove or bypass your small intestine also can lead to osteomalacia.
• Celiac disease. In this autoimmune disorder, the lining of your small intestine is damaged by consuming foods containing gluten, a protein found in wheat, barley and rye. A damaged intestinal lining doesn't absorb nutrients, such as vitamin D, as well as a healthy one does.
• Kidney or liver disorders. Problems with your kidneys or liver can interfere with your ability to process vitamin D.
• Drugs. Some drugs used to treat seizures, including phenytoin (Dilantin, Phenytek) and phenobarbital, can cause osteomalacia.

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The risk of developing osteomalacia is highest in people who have both inadequate dietary intake of vitamin D and little exposure to sunlight, such as older adults and those who are housebound or hospitalized.

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If you have osteomalacia, you're more likely to experience broken bones, particularly in your ribs, spine and legs.

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While you may initially consult your family physician, he or she may refer you to a rheumatologist — a doctor who specializes in arthritis and other diseases of the joints, muscles and bones.

What you can do
You may want to write a list that includes:

• Detailed descriptions of your symptoms
• Information about medical problems you've had
• Information about the medical problems of your parents or siblings
• All the medications and dietary supplements you take
• Questions you want to ask the doctor

What to expect from your doctor
Your doctor will want to know if there's anything in your medical history — such as celiac disease or gastric bypass surgery — that may increase your risk of vitamin D deficiency. He or she will ask about any pain you've been having, and may press on your bones to check for tender spots.

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In order to pinpoint the underlying cause of osteomalacia and to rule out other bone disorders, such as osteoporosis, you may undergo one or more of the following tests:

• Blood and urine tests. In cases of osteomalacia caused by vitamin D deficiency or by phosphorus loss, abnormal levels of vitamin D and the minerals calcium and phosphorus are often detected.
• X-ray. Slight cracks in your bones that are visible on X-rays, referred to as Looser transformation zones, are a characteristic feature of people with osteomalacia.
• Bone biopsy. During a bone biopsy, your doctor inserts a slender needle through your skin and into your bone to withdraw a small sample for viewing under a microscope. Although a bone biopsy is very accurate in detecting osteomalacia, it's not often needed to make the diagnosis.

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When osteomalacia arises from a dietary or sunlight deficiency, replenishing low levels of vitamin D in your body usually cures the condition.

Generally, people with osteomalacia take vitamin D supplements by mouth for a period of several weeks to several months. Less commonly, vitamin D is given as an injection or through a vein in your arm.

If your blood levels of calcium or phosphorus are low, you may take supplements of those minerals as well. In addition, treating any condition affecting vitamin D metabolism, such as kidney failure or primary biliary cirrhosis, often helps improve the signs and symptoms of osteomalacia.

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.

Osteomalacia caused by inadequate sun exposure or a diet low in vitamin D often can be prevented. Here are a few suggestions to help reduce your risk of developing osteomalacia:

• Spend a few minutes in the sun. For most people, 15 minutes of direct sun exposure a couple of times a week is sufficient for proper vitamin D production.
• Eat foods high in vitamin D. These include foods that are naturally rich in vitamin D, including oily fish (salmon, mackerel, sardines) and egg yolks. Also look for foods that are fortified with vitamin D, such as cereal, bread, milk and yogurt.
• Take supplements, if needed. If you don't get enough vitamins and minerals in your diet or if you have a medical condition affecting the ability of your digestive system to absorb nutrients properly, ask your doctor about taking vitamin D and calcium supplements.

©1998-2009 Mayo Foundation for Medical Education and Research (MFMER). Terms of use.