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AIDS virus can lurk for 60 years, study finds


April 27, 1999
Web posted at: 10:24 a.m. EDT (1424 GMT)

In this story:

Hiding in the immune system

Researchers aim fight at T-cells


WASHINGTON (CNN) -- HIV can hide in the human immune system for up to 60 years, even when patients take strong drug "cocktails" that reduce the virus to nearly undetectable levels, scientists said Monday.

Their findings, reported in "Nature Medicine," are bad news for doctors who had hoped the drugs could flush out the virus within three to five years.

Dr. Robert Siliciano and colleagues at Johns Hopkins University School of Medicine discovered HIV can evade even the most powerful anti-viral drugs available and remain hidden in what they described as reservoirs in the immune system.

"What we are showing is that there is a mechanism by which the virus can persist, essentially, for life, even in patients who are on optimal therapy as we currently define it," Siliciano told Reuters in a telephone interview.

The research team looked at 34 patients who were on the highly active antiretroviral therapy (HAART) drug "cocktails" and in whom the virus was suppressed to near-zero levels.

Hiding in the immune system

Researchers already had found that the virus hides in memory T-cells -- the immune system cells that are assigned to recognize a new invader and then remember it in case it ever attacks again, making it easier for the body to respond next time.

The latent pools of virus are hidden in white blood cells that are "resting" and do not activate until needed to fight an infection, such as influenza. If called upon to fight the flu, doctors fear, these resting immune-fighter cells could flood the patient's system with HIV.

AIDS experts hope a way can be found to activate these memory T-cells and thus expose the virus hiding in them to HAART. The drugs only work when the virus is actively replicating.

"We know that immunologic memory lasts 60 years. For example, if you have a measles infection as a child, you are protected 60 years later," Siliciano said.

The researchers did calculations to see if the HIV-infected memory T-cells would last this long and found they probably would.

Siliciano said the discovery of the persistence of the reservoirs "doesn't mean a cure for HIV is impossible, but it is an obstacle."

The discovery "emphasizes that patients need to stay on their medicine possibly for the rest of their lives," Siliciano said.

Researchers aim fight at T-cells

Some doctors, though, including several of those contributing to this latest research, believe it may be possible to take some patients off the drugs, which can have some serious and potentially dangerous side effects.

These doctors believe it may be possible to speed up the elimination of the hidden reservoirs of virus by tricking the body into fighting the resting immune-fighter cells.

Dr. Anthony Fauci at the National Institutes of Health is one of those attempting to find a faster way to flush the HIV reservoirs. He's using an old cancer drug, Interleukin-2 (IL-2), to boost the immune systems into fighting the resting HIV-infected cells.

Italian researcher Dr. Franco Lori, with labs at Georgetown University, is using another cancer drug, hydroxyurea, to achieve a similar effect. Both report promising early results in a few patients.

But Fauci stops short of using the word "cure," saying the ultimate test will be to stop all HIV therapy entirely and confirm the virus doesn't come back.

Fauci said he believes the discovery of the longer-than-expected life span of the virus confirms he and others are moving in the right direction.

"Those cells are not going to go away spontaneously. They won't eradicate on their own, so we have to figure out how to boost immunity and enhance the immune system to keep these pools suppressed without the help of drugs," he said.

As more patients experience problems with today's best drugs, doctors worry whether they can keep patients on such medicines for a lifetime. Patients who'd hoped they might have to take the two dozen or more pills each day for only a few years may face a much longer fight to be free of the AIDS virus.

Reuters contributed to this report.

FDA approves new drug to fight HIV
April 16, 1999

Centers for Disease Control and Prevention
National Institutes of Health (NIH) Office of AIDS Research (OAR)
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