ad info

CNNin
 MAIN PAGE
 WORLD
 ASIANOW
 U.S.
 LOCAL
 POLITICS
 WEATHER
 BUSINESS
 SPORTS
 TECHNOLOGY
 NATURE
 ENTERTAINMENT
 BOOKS
 TRAVEL
 FOOD
 HEALTH
 AIDS
 Alternative
 Cancer
 Diet & Fitness
 Heart
 Men
 Seniors
 Women
 STYLE
 IN-DEPTH

 Headline News brief
 daily almanac
 CNN networks
 CNN programs
 on-air transcripts
 news quiz

  CNN WEB SITES:
CNN Websites
 TIME INC. SITES:
 MORE SERVICES:
 video on demand
 video archive
 audio on demand
 news email services
 free email accounts
 desktop headlines
 pointcast
 pagenet

 DISCUSSION:
 message boards
 chat
 feedback

 SITE GUIDES:
 help
 contents
 search

 FASTER ACCESS:
 europe
 japan

 WEB SERVICES:
Health

Doctors build a new thumb joint for injured man

Operation is a first in tissue engineering on humans

August 15, 1998
Web posted at: 6:32 p.m. EDT (2232 GMT)

BOSTON (CNN) -- When surgeons built a new thumb joint Friday, it was a tiny step forward for reconstructive surgery -- about an inch. But according to researchers, that inch is an important first step in a new field of medicine.

The process is called tissue engineering: doctors harvest key cells from a patient's body, culture them, and shape them to create a new organ or body part.

Most of this work has been done on animals, but on Friday researchers at the University of Massachusetts Medical Center performed an operation to restore a man's thumb. Most of the last joint of his thumb had been lost in a car accident.

The surgeons built a scaffolding in the same shape as the bone in the last thumb joint.

That scaffolding was then encased in flaps of skin and fat at the end of his thumb, and stem cells destined to grow into bone were put into the scaffolding.

Bone cells grow to fill scaffolding

Capillaries were diverted to feed those immature bone cells, with the hope they will grow into the shape of the scaffolding, and provide the man with skeletal structure for a new thumb tip.

If this procedure works, they will perform a second operation to attach cartilage and tendons, so it can become a working appendage.

The key researcher, Dr. Charles Vacanti, said the operation appeared successful, but that it would take 12 to 16 weeks before they knew if the new bone was forming properly.

The patient was released from the medical center Saturday, according to the center's administrative manager, Steven Pease, but will return frequently for evaluations.

10 years of trials on animals

Vicanti said they had been working on these techniques in animals for about 10 years and had demonstrated their ability to build new ears and tracheas for animals.

Friday's operation was their first attempt at creating new bones for humans. The researchers said they were optimistic because of their success in the animal models.

Growing skin, bone, cartilage and tendons is quite practical, but they say the holy grail of tissue engineering -- nerves -- is still out of reach.

In order to create a whole new finger or limb, nerves would have to be grown, too, so that feeling and motor control could be conducted.

The technology for growing new nerves is still in it's earliest stages, even though some preliminary success has been reported in test trials with rats.

Latest Headlines

Today on CNN

Related sites:

Note: Pages will open in a new browser window

External sites are not
endorsed by CNN Interactive.

SEARCH CNN.com
Enter keyword(s)   go    help

  
 

Back to the top
© 2000 Cable News Network. All Rights Reserved.
Terms under which this service is provided to you.
Read our privacy guidelines.