Before him, "there hasn't really been anybody who I saw doing NFL and neurosurgery," the 6-foot-2 former NFL player said in an interview with CNN's chief medical correspondent, Dr. Sanjay Gupta.
Now, Rolle will be treating patients and training amid concerns and contention within the medical field about the safety of American football. He wants to help his two worlds -- medicine and football -- find common ground, he said.
Not until "toward the end of my career, I started to think about concussions and what the effects of repetitive concussions can do," he said.
"Football has done so much for me, given me friends, family, given me life lessons that now I can use in the operating room or just as a leader," he said. "I would hate to see it go, and I would love to see it around."
A blow to the head, such as what might be experienced during a tackle in a football game, can cause a concussion
, a type of traumatic brain injury.
Rolle believes he has a duty to talk to younger players about safely playing the sport he loves.
"The fundamentals have to be emphasized: tackling the correct way. Having the right equipment. Making sure that you don't have very violent practices or contact practices," said Rolle, who sees brain injuries in sports and pediatrics as specialties of interest.
"I will tell you in person, 'Yes, play, but be careful; be safe, and understand some of these things that need to go into it for you to enjoy it,' " he said.
The tight-knit Rolle brothers
Rolle's interest in both neuroscience and football started at a young age, with help from his four older brothers: Marchant, Marvis, Mordecai and McKinley.
He was in the fifth grade when he read the book "Gifted Hands" by Dr. Ben Carson
, which sparked his interest in medicine. Since then, Rolle said, neurosurgeon Carson has become something of a mentor.
Their father, Whitney Rolle, said Myron's oldest brother, Marchant, gave Myron the book.
"That kind of propelled him into that area," Whitney said.
While Marchant gave Myron books to read, his third oldest brother, Mordecai, taught him the game of football.
Myron quickly excelled on the field, and McKinley, the brother closest in age to Myron, often trained with him. Now, McKinley is a high school football coach and teacher in Florida, where he also serves as Myron's business manager.
Growing up, Whitney said, Myron's older brothers not only encouraged him to pursue his dreams, they also had his back.
When the boys were children, "they put dishwashing liquid in the aquarium, and let me tell you, the entire living room was in bubbles," Whitney said, chuckling at the memory.
At the time, Whitney repeatedly asked his sons who was behind the bubble prank. No one answered.
"I threatened them. I told them I was going to punish them, and they would not tell on each other. Nobody would squeal," Whitney said.
"As much as I was being tough on them, I was in the back of my mind smiling to see how they just stick together," he said. "I've always enforced that they care for each other. They support each other."
Whitney and his wife, Beverly, moved with the oldest three boys from the Bahamas to the United States in 1980, when Whitney was transferred to work at Citibank.
Then came two more sons. By the time Myron was born in 1986, the family had settled into a middle-class life in New Jersey.
He points to his parents, and the sacrifices they made to provide for him and his brothers, as a source of his motivation today.
"When I was younger, trying to afford football camps, my parents would sometimes have to miss bills," he said. "They sacrificed these things for me because they saw I had a goal.
"My repayment for that sacrifice is to continue to move forward, be the best I possibly can be, whether that's on the football field when I played or now as a future neurosurgeon."
From suiting up to scrubbing up
Among all of Rolle's efforts to be the best he can be, he points to November 22, 2008, as the day when he felt the most proud.
On that day, Rolle -- then a student athlete at Florida State University -- had to be in Birmingham, Alabama, to interview as a Rhodes Scholar finalist. At the same time, he was expected to play in a game against the University of Maryland in College Park.
Dating back to 1904, Rhodes Scholarships
are the oldest and among the most prestigious international fellowship awards in the world. Each year, only 32 American students are selected as Rhodes Scholars to pursue a degree at the University of Oxford in England.
To interview, Rolle took a quick flight to Birmingham. After he completed the two-hour interview, he said, he waited another hour or so to receive the results.
"The judges came out and said that I won the scholarship," Rolle said, but he didn't have much time to celebrate. He still had a game to play.
"I got on a plane from Alabama to Maryland, got to the game around the second quarter," he said.
McKinley, the brother closest in age, was in the press box when Rolle arrived at the stadium in Maryland. Their other family members were in the stands.
"I just remember there was so much emotion going through our family at that time," McKinley said.
When Rolle arrived at the stadium, he received a standing ovation. Then, on that chilly November night, his team won the game
Rolle postponed his NFL career for a year to complete his Rhodes Scholarship at Oxford, where he earned a master's degree in medical anthropology.
He then went on to play safety for the Tennessee Titans
and the Pittsburgh Steelers before retiring in 2013 to attend the Florida State University College of Medicine. He graduated on Saturday.
"I'm glad that I walked into my purpose," Rolle said. "I'm glad that I walked into something that was a smooth transition from football."
He has already become something of a family doctor, McKinley said. If a relative suffers an injury or illness, it's likely Rolle will be summoned for help.
"I know he's going to be one of the best neurosurgeons in the world," McKinley said. "Myron has worked for everything and has earned everything that has happened to him."
McKinley recalled moments when he would walk downstairs in the middle of the night and see Myron studying at 2 or 3 o'clock in the morning.
"He studied for this, and he has prepared for it," McKinley said.
After interviewing Rolle, Gupta, a practicing neurosurgeon, said that such a strong work ethic will be needed in his future.
"There's no question Myron will probably be working harder than he's ever worked in his life for the next seven years, despite having been in the NFL and training as a professional athlete," Gupta said. "I think, however, it is all about immersing yourself in your task, and Myron has shown that he's nearly superhuman at doing that. I think he unquestionably has a bright future as a neurosurgeon."