The American Film Institute's top villains include some of the most evil characters to ever grace the silver screen, from a criminal mastermind with an appetite for human flesh to a jealous queen with magical powers.
Anthony Hopkins plays Hannibal Lecter, a cannibalistic mastermind, in "The Silence of the Lambs."
Anthony Perkins plays Norman Bates, a knife-wielding serial killer, in Alfred Hitchcock's "Psycho."
David Prowse physically portrayed Darth Vader in "Star Wars," though James Earl Jones dubbed his dialogue throughout the film.
In "The Wizard of Oz," the Wicked Witch of the West, played by Margaret Hamilton, vows to take revenge on Dorothy after her house kills a fellow witch.
Louise Fletcher won an Oscar for her portrayal of the cruel Nurse Ratched in "One Flew Over the Cuckoo's Nest."
Lionel Barrymore famously played a balding, wheelchair-bound businessman, Mr. Potter, in "It's a Wonderful Life."
Glenn Close was nominated for an Oscar for her role as Alex Forrest, who develops a "Fatal Attraction" to a married man with whom she has an affair.
Barbara Stanwyck plays the manipulative Phyllis Dietrichson in Billy Wilder's "Double Indemnity," in which she plots to have her husband killed for the insurance money.
Regan MacNeil becomes possessed with a demonic spirit in "The Exorcist." Linda Blair was nominated for an Oscar for best actress in a supporting role for her head-spinning performance.
The Queen in "Snow White and the Seven Dwarfs" becomes jealous when her "mirror, mirror on the wall" informs her that she is no longer the fairest of them all. In her elderly form, she offers a poisoned apple to the film's heroine.