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The artists catch your eye, but don't lose sight of the best of the rest of Santiago.
CNN Insider Guides are thoroughly checked for accuracy. Given the fluid nature of the travel industry, however, some listings may fall out of date before guides can be updated. The best practice is to confirm current information on official websites before making plans to visit any business or attraction.
(CNN)Head east and in no time you'll reach the Andes; west and you hit the beaches and coastline of the Pacific Ocean.
Located in the middle of a long, narrow country, that directional review has for too long described Santiago's value to many onward-bound travelers.
But Santiago is an undervalued treasure among South American cities.
It's worth putting off Chile's other attractions a few days to get to know the best of Santiago's culture, food and pulsing nightlife.
There's a boomtown feel around Santiago these days.
The national economy is buoyant, corruption is low and the city's infrastructure is solid.
The last decade has seen countless bars, hotels and restaurants open.
Here's where to find the best of Santiago.
The Aubrey exudes class -- and arches -- inside and out.
The Aubrey is made up of two 1920s mansions.
Like a family home, the heart of the hotel is a large staircase.
Wide hallways come off each landing with art deco furniture, inviting you to sit back and take advantage of the constant supply of tea, coffee and fresh baked items.
The dark wood paneling is offset with block colors, printed fabrics and crystal chandeliers.
The restaurant opens onto a cobbled patio and outside there's an outdoor swimming pool with massage jets.
In the center of the wealthy El Golf neighborhood, the 205-room Ritz Santiago delivers on the luxury and service of the well-known brand.
Among features are four restaurants serving top Chilean cuisine, a spa, more than 9,000-square-feet of meeting space, rooftop fitness center overlooking the Andes and many rooms with tourist-board views of the Santiago skyline.
Among numerous awards and recognition, Travel+Leisure picked it as a top 10 hotel in Latin and South America for 2012.
In his mid-30s, Mexico City native and Sukalde owner/chef Matías Palomo calls the secret to his success a "knowledge of flavor."
He came to Chile at age 17 and fell in love with the local cooking traditions and ingredients, which he uses to stunning effect in his Chilean fusion cuisine.
There's lots of seafood on the menu, as well as novel creations such as organic salad with king prawn, rice paper and truffled vinaigrette.
There's a fun drink list, too, that includes papaya and calafate sours.
Sukalde, Nueva Costanera #3451, Santiago Chile; +56 2 228 5516
You'll find lots of seafood at this long-established best of Santiago award-winner.
What the restaurant describes as its "modern French" cuisine might take in anything from Patagonian hake with ratatouille and yellow tomato coullis to abalone served with a cilantro, parsley and olive oil sauce to superb grilled meats.
You'll find a variety of restaurants along Nuevo Costanera, so if Puerto Fuy is full or the menu doesn't appeal, you should find something nearby.
Puerto Fuy, Avenida Nueva Costanera 3969, Santiago Chile; +56 2 208 8908
El Jardín de Epicuro
Fine tapas, fantastic piscos.
This fun, fashionable place has a nice selection of tapas (ham, seafood, cheese, tortillas, tostadas), as well as heartier grilled meats and fish.
The bar serves a variety of excellent piscos.
The warm brick-and-wood interior will make you want to hang out for a while.
Astrid y Gastón is the Latin American chain sensation at the forefront of the upscale Peruvian cuisine movement that's taken hold across Spain, South America and parts of North America.
Maize, potatoes and quinoa take care of the starches.
From there the cuisine might best be described as Peru-meets-the-world. Roast lamb, duck, abalone, foie gras, even shrimp-stuffed ravioli make their ways onto the menu.
Don't be put off by the "chain" description.
Chef/co-founder Gastón Acurio is a celebrity chef often described along the lines of a Latin American Jamie Oliver and his upscale restaurant is a best of Santiago experience.
Astrid & Gaston, Antonio Bellet, 201 Providencia, Santiago Chile; +56 2 650 9125
De La Ostia
There's high energy and generally a happy crowd at this informal neighborhood favorite that does excellent sangria and pisco sours.
Fans often describe the vibe (and sangria) as more Spanish than Chilean.
The tapas are decent (calamari, tortilla with potato and chorizo), but this is mostly a place to hang out for a few rounds.
De la Ostia, Orrego Luco 065, Santiago Chile; +56 2 335 1422
The Opera Catedral's upstairs restaurant is also a winner.
Of many excellent bars in Lastarria, Opera Catedral is a classy pick.
With wood paneling and wood ceiling, the medium-sized drinkery showcases a variety of live music, from DJs to torch singers.
There's a good restaurant on the top floor.
Opera Catedral, Jose Miguel de la Barra esq. Merced, Santiago Chile; +56 2 664 3048
This "100 percent Chileno" bar might seem rough around the edges to some, but if you're looking for an easy authentic local experience (yes, it's touristy, but locals come as well), this is a good place.
The big draw is the Chilean national cocktail, the "terremoto" (earthquake).
It's intended to make you feel shaky afterward.
The terremoto is made with a sweet, fermented wine called pipeño and served with fernet alcohol and pineapple sherbet or sorbet in a large glass.
You get an "aftershock" (same drink, half the amount) following the first round.
This is without doubt a best of Santiago experience and not to be missed.
La Piojera, Aillavillu, 1030 near Puente Cal y Canto, Santiago Chile; +56 2 698 1682
This chic, modern wine bar is the place to do it.
The special flight of six Chilean wines are each paired with a light tapas.
Bocanariz, Avenue Jose Victorino Lastarria 276 Santiago Historico, Santiago Chile;
Club La Feria
Santiago's nightlife doesn't get a lot of international hype, but the late-night club scene in the capital can stand toe-to-toe with any on the continent.
Club La Feria is the reigning DJ, dance and light-show champ.
It's loud and has plenty of scenery to gawk at, but the smallish club fits only 250 people.
That means the dance floor is PACKED.
Show up before midnight and you'll hear crickets chirping.
As at most Santiago discos, the heavy activity gets going between 2 and 3 a.m. (And ends at 5 p.m., when bars close in the city.)
Club La Feria, Constitucion 275, Santiago 7520291 Chile; +56 22 735 8433
Pueblito Los Dominicos
This cute, adobe-and-tile-roofed craft market is the place to browse and buy small gifts and souvenirs: clothes, fabrics, ceramics, paintings, furniture, carvings, glasswork, more.
A series of stalls in a small village-like setting sell crafts made by more than 150 Chilean artists.
There are relaxing outdoor cafes in the complex with coffee and empanadas.