Margot Robbie will portray Batman villain (and the Joker's paramour) Harley Quinn in the eagerly awaited film "Suicide Squad."
Krysten Ritter stars as "Jessica Jones" in the Netflix series based on Marvel Comics' "Alias," about a semi-retired superhero-turned-private eye.
Gal Gadot's Wonder Woman from "Batman v Superman: Dawn of Justice" was unveiled at 2014's San Diego Comic-Con, and her first onscreen appearance in a trailer the following year. Her solo movie is due out in 2017.
Jennifer Lawrence is back as archer and freedom fighter Katniss Everdeen in "The Hunger Games: Mockingjay, Part 1" and coming soon, the final film, "Part 2."
Zoe Saldana stars in not one but three major sci-fi movie franchises. She's Lt. Nyota Uhura in the rebooted "Star Trek" movies, stars as former assassin Gamora in the Marvel hit "Guardians of the Galaxy" and is Neytiri in "Avatar" and its planned sequels.
Nichelle Nichols played Lt. Uhura, the communications officer on the Starship Enterprise, in the original "Star Trek" TV series and films. In the recent movie reboots, her role was played by Zoe Saldana.
Set in the post-World War II years, the new series "Marvel's Agent Carter" follows the continuing adventures of Peggy Carter, after the presumed death of her boyfriend Steve Rogers (a.k.a. Captain America).
Scarlett Johansson stole the movie in her first scene in "The Avengers" -- not an easy thing to do. Black Widow was pretty kickass in the film.
"Lucy" seems to have boosted Johansson's action movie cred. The actress is reportedly starring in the live-action remake of "Ghost In The Shell."
Buffy Summers, played by Sarah Michelle Gellar, was vampires' worst nightmare in the beloved TV series "Buffy the Vampire Slayer."
Lucy Lawless found fame on TV as the force of nature that was "Xena, Warrior Princess."
Sigourney Weaver faced off with aliens not once, but four times in the "Alien" films and became the very model of the modern sci-fi heroine.
Blasting her way out of the Death Star, we knew fairly quickly that Leia was not one to be trifled with in the "Star Wars" films. Carrie Fisher played the role.
Linda Hamilton (pictured) was the best known Sarah, but we look forward to seeing how Emilia Clarke takes on the Terminator in the upcoming reboot.
Carrie-Anne Moss' Trinity was the first main character we saw in the "Matrix" and immediately, we were hooked.
Tatiana Maslany's "clone club" brings new meaning to the term "girl power" on the critically-acclaimed BBC America series "Orphan Black." Maslany plays Sarah Manning on the show.
She may not have "wanted to believe" like her partner Fox Mulder, but Gillian Anderson as Scully on "The X-Files" was one of the best sci-fi characters of the past 20 years.
It's hard to choose a favorite Lois as there's been so many over the years, but we'll go with Margot Kidder's tough as nails reporter from the Christopher Reeve "Superman" movie series.
They switched genders on us with this character in the 2000s reboot, and casting Katee Sackhoff as Starbuck in "Battlestar Galactica" was a stroke of genius.
We didn't even see her face but when she used her katana to slice through zombies at the end of season two, we knew we really liked Michonne, actress Danai Gurira, from "The Walking Dead" right away.
Emma Watson's Hermione Granger in the "Harry Potter" movies always knew just the right spell to get out of any situation.
We'd rather not remember Halle Berry's take on the seductive thief, Catwoman, but Julie Newmar, Eartha Kitt, Lee Meriwether and Anne Hathaway were all splendid in the role. But for our money, Michelle Pfeiffer (pictured) in "Batman Returns" is the Catwoman to beat.
Leela, the pilot of the Planet Express ship, often acts as the voice of reason between Fry, Professor Farnsworth and the others in her crew on "Futurama." Katey Sagal is the voice of Leela.
Emilia Clarke's Daenerys Targaryen from "Game of Thrones" is so tough that she will literally walk through fire.
Mal trusts no one more than his right-hand woman Zoe, played by Gina Torres, in the beloved, short-lived series "Firefly."