(CNN) -- Former first lady Barbara Bush remained hospitalized on Wednesday in Houston for a "respiratory-related issue."
Bush, 88, the wife of the 41st President, George H.W. Bush, and the mother of the 43rd, George W. Bush, was admitted Monday to Methodist Hospital, family spokesman Jim McGrath said in a statement.
In his latest update, McGrath said there had been no change in her condition but provided no further details beyond saying she was suffering from a "respiratory-related issue."
He said previously she was in "great spirits" and receiving visitors, including her husband and other members of her family.
President and Mrs. Obama issued a statement offering their thoughts and prayers and wishing her a "speedy recovery."
Former President Bill Clinton tweeted that he will "be rooting for" her full recovery.