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Angelina Jolie undergoes double mastectomy

By Ed Payne, CNN
updated 8:09 AM EDT, Thu May 16, 2013
STORY HIGHLIGHTS
  • A blood test can detect if a woman is "highly susceptible" to breast or ovarian cancer
  • Jolie reveals she carries a gene that increases her risk for cancer
  • Her mother died of ovarian cancer in 2007
  • Jolie is a U.N. special envoy and won an Oscar for "Girl, Interrupted"

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(CNN) -- Actress Angelina Jolie announced in a New York Times op-ed article on Tuesday that she underwent a preventive double mastectomy after learning that she carries a mutation of the BRCA1 gene, which sharply increases her risk of developing breast cancer and ovarian cancer.

"My doctors estimated that I had an 87 percent risk of breast cancer and a 50 percent risk of ovarian cancer, although the risk is different in the case of each woman," Jolie wrote. "Once I knew that this was my reality, I decided to be proactive and to minimize the risk as much I could. I made a decision to have a preventive double mastectomy."

Five reasons we love Angelina Jolie

Jolie's mother, actress and producer Marcheline Bertrand, died of ovarian cancer in 2007 at the age of 56. Jolie is 37 years old.

In the Times op-ed, titled "My Medical Choice," Jolie said she finished three months of medical procedures at the Pink Lotus Breast Center in California on April 27 that included the mastectomies and reconstruction.

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Opinion: Jolie's choice carries risks with benefits

A mastectomy is an operation that removes all or part of the breast.

She wrote that her experience involved a three-step process. On February 2, the actress had a procedure that increases the chance that the nipple can be saved. Two weeks later, she had major surgery where the breast tissue was removed and temporary fillers were put in place. Nine weeks later, she described undergoing "reconstruction of the breasts with an implant."

"There have been many advances in this procedure in the last few years," she said, "and the results can be beautiful."

Why double mastectomies are up

"I wanted to write this to tell other women that the decision to have a mastectomy was not easy. But it is one I am very happy that I made," Jolie wrote. "My chances of developing breast cancer have dropped from 87 percent to under 5 percent."

BRCA stands for breast cancer susceptibility genes, a class of genes known as tumor suppressors, according to the National Cancer Institute.

Hollywood applauds Jolie for going public with surgery

Mutations of the BRCA1 and BRCA2 genes have been linked to hereditary breast and ovarian cancer. A blood test can determine if a woman is "highly susceptible" to the cancers.

Fellow actress Christina Applegate had a similar procedure in 2008. She also had a mutation of the BRCA1 gene.

My preventive mastectomy: Staying alive for my kids

Jolie may be best known for title role in the "Lara Croft" series of films, but she also won an Academy Award for best supporting actress in "Girl, Interrupted." She also received a Golden Globe Award and SAG Award for the same role.

Opinion: Jolie's brave message

Jolie serves as a special envoy for the United Nations High Commissioner for Refugees and has visited refugee camps around the world.

The actress has been in a relationship with actor Brad Pitt since the mid-2000s, and they are engaged. The couple has three biological and three adopted children.

Hugh Jackman underwent procedures in November 2013 and May and October 2014 to have basal cell carcinoma removed. His rep told People in October that the actor is "okay now." Hugh Jackman underwent procedures in November 2013 and May and October 2014 to have basal cell carcinoma removed. His rep told People in October that the actor is "okay now."
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On Friday, October 10, Britain's Queen Elizabeth II made Angelina Jolie an honorary dame for her work to root out sexual violence in war zones. While Jolie is now known for her humanitarian works and action movies, she has been in the spotlight since she was a child. Here's a look at her life. On Friday, October 10, Britain's Queen Elizabeth II made Angelina Jolie an honorary dame for her work to root out sexual violence in war zones. While Jolie is now known for her humanitarian works and action movies, she has been in the spotlight since she was a child. Here's a look at her life.
Life of Angelina Jolie
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Photos: Life of Angelina Jolie Photos: Life of Angelina Jolie

In telling her story, Jolie acknowledged that surgery might not be the right choice for every woman.

Tough choices in cancer gene fight

"For any woman reading this, I hope it helps you to know you have options," Jolie wrote. "I want to encourage every woman, especially if you have a family history of breast or ovarian cancer, to seek out the information and medical experts who can help you through this aspect of your life, and to make your own informed choices."

But for Jolie, the decision ultimately came down to her kids.

"I can tell my children that they don't need to fear they will lose me to breast cancer," she said.

iReporters: BRCA gene not a death sentence

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