New York (CNN) -- More than 30 years after six-year-old Etan Patz disappeared in New York City on his way to the bus stop, police and federal authorities were tearing apart a Lower Manhattan basement Thursday in search of clues as to what happened to the boy who became the face of missing children in America.
Etan Patz disappeared May 25, 1979, a block from his home in the city's SoHo neighborhood. It was the first time he walked to the bus stop by himself.
Authorities said both new and old information led them to a carpenter and part-time handyman who met Etan the day before he disappeared and gave the boy a dollar.
It was interest in the carpenter that prompted authorities to bring a cadaver dog to a SoHo basement, where Etan apparently encountered the 42-year-old carpenter, according to a source with knowledge of the investigation. The dogs picked up the scent of human remains, the source said.
Late Thursday, authorities set up a grid in the basement and were using jackhammers to rip up the concrete floor. They also took out part of the back wall of the basement, an unoccupied area beneath what was once a restaurant.
"We're looking for human remains, clothing or other personal effects of Etan Patz," New York Police Department spokesman Paul Browne said of the current investigation. "It's a very painstaking process."
In 2010, Manhattan District Attorney Cyrus Vance Jr. said his office decided to take another look at the decades-old mystery. FBI leads were then culled from that case file, sources said.
The investigation, which has often been described as a milestone case that helped draw the plight of missing children into the national consciousness, garnered headlines as authorities splashed the child's image on the sides of milk cartons in the hopes of gathering more information.
It's thought to be the first time that step was taken for a missing child.
Etan was officially declared dead in 2001 as part of a civil lawsuit filed by his family against a drifter, Jose Antonio Ramos, a convicted child molester acquainted with Etan's babysitter.
A judge found Ramos responsible for the death and ordered him to pay the family $2 million. He never paid the money.
Though Ramos has been considered a key focus of the probe for years, he has never been charged in the case. He is serving a 20-year sentence in a Pennsylvania prison for molesting another boy and is set to be released later this year.
A source said investigators now also want to expand the pool of possible suspects beyond Ramos.
The carpenter, now 75, is not in custody, though authorities say they know where he is and are currently in contact with him. CNN is not naming the man because he has not been charged with a crime.
Dozens of police and federal agents gathered outside the building on Manhattan's Prince Street on Thursday and are expected to continue their search over the next five days. FBI Special Agent Peter Donald said the bureau's Evidence Recovery Team is at the scene.
"We are cautiously optimistic" that the search will be helpful," FBI Special Agent Tim Flannelly told CNN.
Forensic evidence uncovered at the scene will be analyzed at the FBI laboratory in Quantico, Virginia, the sources said.
It is not clear whether authorities searched the basement in 1979, though a source said it "figured into" the investigation.
Authorities have reason to think the new search could lead to the discovery of the boy's remains at that location, though they remain wary after past leads in the case failed to pan out, according to two sources familiar with the probe.
"I hope they find something," said resident Sean Sweeney, who says he's lived in the neighborhood since 1976.
SoHo, a lower Manhattan neighborhood now known for its boutique shops, art galleries and loft apartments, at the time was considered a grittier locale, where abandoned storefronts dotted the city streets.
Sweeney said he remembers the initial investigation into Etan's disappearance when police first knocked on his door in search of clues.
"That's odd, isn't it," he said, referring to the fact that 33 years later, police are again in his neighborhood searching for the boy.
On the day of his disappearance, Etan's mother, Julie Patz, learned after her son failed to return home from school that he hadn't been in classes that day. She called the school, then called the homes of all his friends. When she found no one who had seen her son, she called police and filed a missing person report.
By evening, more than 100 police officers and searchers had gathered with bloodhounds. The search continued for weeks, but no clues to Etan's whereabouts were found.
The boy's disappearance was thought to raise awareness of child abductions and led to new ways to search for missing children.
President Ronald Reagan named May 25, the day Etan went missing, National Missing Children's Day.
CNN's Tom Foreman contributed to this report.