(CNN) -- Forty-two delegates are up for grabs when Wisconsin holds its Republican presidential primary Tuesday, but for Rick Santorum, much more appears to be at stake.
The Badger State may be the former senator from Pennsylvania's final chance to convince Republicans that the race for the GOP nomination isn't over.
Wisconsin joins Maryland and the District of Columbia in holding primaries on Tuesday. While polls suggest former Massachusetts Gov. Mitt Romney is the overwhelming favorite in Maryland and D.C., Romney holds only a single-digit lead over Santorum in Wisconsin, which could be one of Santorum last opportunities to slow down Romney's march towards clinching the nomination.
"I think that because Wisconsin has been at the political epicenter of this country and represents some of the same arguments that are relevant in every corner of this country, whoever wins this Wisconsin primary is going to have some very serious bragging rights," said Republican National Committee Chairman Reince Priebus, a former chairman of the Wisconsin GOP.
Another strategist sees higher stakes than bragging rights.
"In a race where none of the 'must-wins' have actually turned out to be 'must-wins,' Wisconsin looks to be as close as Republicans have been to functionally wrapping up the nominating contest," says GOP strategist Gentry Collins, a former political director for the Republican National Committee and the Republican Governors Association.
Romney has 571 delegates, according to CNN's estimate. That's more than twice the 264 delegates Santorum holds, but only halfway toward securing the 1,144 delegates needed to clinch the nomination.
"I've got a ways to go before I've got 1,144 delegates, so I'm not counting the delegates before they hatch, but I'm going to keep working very hard and hope I get a good strong sendoff from Wisconsin, Romney said Saturday in Fitchburg, Wisconsin. "I've got a good boost from the folks in Illinois. And if I can get that boost also from Wisconsin I think we'll be on a path that'll get me the nomination well before the convention."
Since Romney's double-digit victory in Illinois two weeks ago -- followed by a wave of some of the party's major names and elder statesmen endorsing Romney and urging a quick conclusion to the divisive nomination battle -- the conversation regarding Romney seems to have changed, with the front-runner increasingly being called the inevitable nominee.
At an event in Middleton, Wisconsin, on Sunday, Romney said that the nominee "will probably be me."
Regardless of the increasingly daunting odds facing Santorum, he doesn't sound like a candidate about to end his White House bid.
"Cutting it short and getting the wrong candidate is worse than making this a fight for the heart and soul of America and the heart and soul of the Republican party," Santorum said Sunday in Green Bay, Wisconsin.
While Romney is far ahead of Santorum, former House Speaker Newt Gingrich and Rep. Ron Paul of Texas in the hunt for delegates, exit polls indicate he still has a problem locking in the conservative base of the party. And that continues to fuel Santorum's bid.
"The reason I'm here is because what the establishment is trying to shove down the throats of the folks of this country on the Republican ticket isn't being swallowed. And the reason it's not being swallowed is because they want someone who reflects their values, someone that they can trust, someone who's an authentic conservative," Santorum told voters Sunday in Milwaukee, Wisconsin.
While appearing more to be in general-election mode, targeting his firepower at President Barack Obama rather than his GOP rivals, Romney's not leaving anything to chance in Wisconsin, campaigning in the state over the three days leading up to the primary. And his campaign, along with an independent pro-Romney super PAC, will outspend Santorum and his super PAC by a nearly 4-1 margin to run TV ads in the state.
That led Santorum to ask Sunday in Mischicot, Wisconsin, "Why is he (Romney) spending $4 million in Wisconsin, if this race is over? If it's over and there's no chance, then why he is bothering even campaigning anymore, if it's over?"
Santorum has some help on the ground in the Badger State.
"Santorum's very capable deputy campaign manager, Jill Latham, ran the Republican party's turnout programs in Wisconsin through the 2006 cycle and knows the state well. She will be a big tactical asset in Wisconsin, and should be able to plus-up Santorum's chances on the ground," said Collins, who ran Romney's 2008 operation in Iowa but is not taking sides in this cycle.
A Santorum win in Wisconsin on Tuesday could revive the headlines that Romney is having trouble locking up the nomination. But a Santorum loss will most likely increase the chorus of voices for him to drop out.
"If Romney clean-sweeps Tuesday night, it's very hard to see a path for Santorum," CNN Chief Political Correspondent Candy Crowley said.
After Tuesday, there are three weeks before five more states vote on April 24. Romney appears to be the favorite in four of those states: New York, Connecticut, Rhode Island and Delaware. The fifth, Pennsylvania, is Santorum's home state, but polls show his once-large lead there has disappeared.
"Do you want to lose your home state? I don't think so. I think if Santorum wants any kind of future, how do you stay in and lose Pennsylvania," asked Crowley, anchor of CNN's 'State of the Union.'
Collins agrees, adding, "if it looks like Romney has the nomination locked up before then, Santorum will need to be careful to avoid a serious embarrassment in his own home state."
The candidate and his campaign say there's no talk of dropping out until Romney clinches the nomination. Crowley says any public mention right now of possibly calling it quits would be detrimental to Santorum.
"The minute you show any leg on getting out, your supporters are going to vote for Romney. So you're kind of stuck," she said. "Your words have to be bravado. I think his words on Wednesday will tell us more about his strategy than his words on Monday."
Santorum Communications Director Hogan Gidley points towards May, which looks friendly to the candidate. Santorum could be the favorite in primaries in North Carolina and West Virginia on May 8, Nebraska on May 15, Arkansas and Kentucky on May 22, and Texas a week later.
But it could be too little, too late by May. Sen. Hillary Clinton won most of the final contests against Sen. Barack Obama in the marathon 2008 Democratic presidential nomination battle, but in the end it didn't matter.
Says Crowley: "Santorum will win some states, but at the moment it's not about winning states, it's about winning the nomination, and that's where it gets difficult for Santorum."