Washington (CNN) -- Newt Gingrich is determined to stay in the race for the Republican nomination, his communications director said Wednesday, even though he's laid off one-third of his staff and faces increasing calls to cede the contest to front-runner Mitt Romney.
Joe DeSantis said Gingrich's decision to lay off staff and replace his campaign manager was a reorganization that would enable him to fight on to the Republican National Convention in the summer and win the nomination there.
The overhaul comes as a CNN/ORC International poll released Tuesday indicated that most Republicans would like to see Gingrich and Texas Rep. Ron Paul end their White House bids.
But they want conservative challenger Rick Santorum to stay in the race.
The poll, conducted over the weekend, showed that about six in 10 Republicans wanted Gingrich and Paul to halt their campaigns, while a similar number supported Santorum continuing his bid.
DeSantis said the poll "showed that Gingrich dropping out of the race would help Mitt Romney dramatically more than it helps Rick Santorum."
This would "virtually guarantee Mitt Romney the nomination," he said, as he urged conservatives to rally behind Gingrich to keep the former Massachusetts governor from victory.
According to CNN's latest estimate, Romney has secured 569 delegates and needs 575 more to reach the 1,144 required to clinch the GOP nomination.
Santorum, the former Pennsylvania senator, has 262 delegates, with Gingrich at 136 and Paul at 71.
DeSantis said Gingrich was still "pretty competitive" in terms of delegate numbers and would now focus on picking up delegates in key states and taking the fight to President Barack Obama on the national stage.
Meanwhile, the staff layoffs and reorganization reflect the need to plan around the "financial realities" of the campaign, DeSantis said.
Gingrich's campaign is being driven by small donations, he said, with 95% of its 176,000 donors giving less than $250 but a "steady stream" of donations still coming in.
Gingrich's team has struggled to keep pace with Romney's high spending in key states.
Romney took his campaign to the late-night airwaves Tuesday, making an appearance on "The Tonight Show" with host Jay Leno.
After cracking a few jokes, Romney and Leno settled into a discussion on health care. Many conservatives are uncomfortable with a health care reform package signed by Romney when he was governor of Massachusetts. The Obama administration later modeled -- in part -- its health care reform law on the Massachusetts plan.
Despite the poll showing long odds, none of the three trailing candidates seems close to giving up.
Santorum challenged the delegate math, telling CNN's Wolf Blitzer Monday that the Republican race was likely to continue until the party's national convention in August in Florida.
"There may be someone with what they say are enough delegates, but as you also know, Wolf, a huge number of delegates are uncommitted," Santorum said. "They may be for me, or they may be for Mitt, but they're technically uncommitted, and therefore you can't put them in your column."
Gingrich said Tuesday that he would drop out if Romney reaches the 1,144-delegate threshold to claim the nomination. However, Gingrich added he doubted that would happen before the convention.
"Gov. Romney is the front-runner but is a long way from a majority," Gingrich said at Maryland's capitol building in Annapolis. "If (Romney) does get, by the time Utah votes on the 26th of June, if he gets a majority, obviously I will support him and will be delighted to do anything I can to help defeat Barack Obama."
Paul also sounded committed to staying in the race, telling CNN's "Piers Morgan Tonight" Monday that "it's way too soon for you to write anybody off."
"Why should we just throw in the towel because people like you say, 'Hey, throw in the towel'?" Paul asked.
According to the new poll, 36% of Republicans support Romney for the nomination and 26% back Santorum. The two men were effectively tied in CNN's last national survey, in February, with Santorum at 34% and Romney at 32%.
The survey seemed to dispel the commonly held notion that Gingrich and Santorum were vying for conservative support against the more moderate Romney. According to the poll, most of Gingrich's supporters said Romney was their second choice, rather than Santorum.
"If you recalculate the GOP horse race using the Gingrich voters' second choice, Romney's lead over Santorum grows to 15 percentage points -- 45% for Romney and 30% for Santorum -- compared to the 10-point margin Romney currently has in the four-man field," CNN polling director Keating Holland said.
The primary calendar resumes next Tuesday with contests in Wisconsin, Maryland and the District of Columbia. A three-week break follows until April 24, when New York, Pennsylvania, Delaware, Connecticut and Rhode Island vote.
Those contests in more moderate states in the Northeast, mid-Atlantic and Midwest appear to favor Romney over Santorum, with the possible exception of Pennsylvania, which Santorum represented in Congress for nearly two decades.
CNN's Paul Steinhauser, Tom Cohen and Mark Preston contributed to this report.