(CNN) -- It was supposed to be a celebration -- sun, fun and relaxation on a tropical island for recent graduates savoring the heady taste of approaching adulthood.
But instead, the trip to Aruba by a group of Birmingham, Alabama, high school seniors ended in tragedy, as one of their members, 18-year-old Natalee Holloway, never returned home. Questions surrounding her fate are unanswered five years later.
Now, Joran van der Sloot, the youth twice arrested and released in Holloway's disappearance -- seen by many as a privileged playboy who has displayed no remorse or concern over her whereabouts -- has been named a suspect in the stabbing death of a woman in Peru, allegations that hint at a chilling pattern.
Holloway was last seen in the early hours of May 30, 2005, leaving an Oranjestad, Aruba, nightclub with van der Sloot and two other men, brothers Deepak and Satish Kalpoe. She was visiting the island with about 100 classmates to celebrate their graduation from Mountain Brook High School in suburban Birmingham.
Holloway failed to show up for her flight home the following day, and her packed bags were found in her hotel room.
Van der Sloot and the Kalpoes were arrested and released in 2005 in connection with the case, then arrested a second time in 2007 after Aruba's then-chief prosecutor Hans Mos said he had received new evidence in the case. Van der Sloot, then attending college in the Netherlands, was brought back to Aruba. But judges ruled the new evidence -- which included an Internet chat the same day Holloway disappeared with one of the three youths writing that she was dead -- was not enough to keep them in custody.
In the years since Holloway vanished, van der Sloot has consistently denied any involvement in her disappearance, police said.
"He's just totally, totally dragged us all through hell," Holloway's anguished mother, Beth Twitty, has said.
In 2008, a videotape surfaced on Dutch television. In it, van der Sloot tells a man he thought was a friend he had sex with Holloway on the beach after leaving the nightclub, then she "started shaking" and lose consciousness. He said he panicked when he could not rescuscitate her and called a friend who had a boat. The two put Holloway in the boat, van der Sloot said, and he went home. The friend told him the next day that he had carried the body out and dumped it into the ocean.
"I don't lose a minute of sleep over it," van der Sloot said.
He later claimed the account was a lie, saying he told the man what he wanted to hear. A court ruled there was not enough evidence to re-arrest him. Aruba chief prosecutor Peter Blanken said the story was "unbelievable and not true."
But it's been van der Sloot's cavalier attitude toward the case that has fueled criticism, as well as conflicting statements he's made. He told Fox News in a 2008 interview he sold Holloway to human traffickers for $10,000, then in a taped interview denied it.
At the time his name first surfaced in the Holloway investigation, suspicion swirled around his parents, particularly his father, an Aruban lawyer training to be a judge. Paul van der Sloot was briefly taken into custody in 2005 on suspicion of involvement in the Holloway case. Authorities said he told his son that police had no case without a body. He was released after three days of questioning.
Holloway's parents, however, have said they met with Paul van der Sloot and continue to believe he had the answers to questions regarding their daughter.
"I remember the day I met with Paul at the prison," Dave Holloway has said. "And the thing that stuck out in my mind was I asked him all the questions, why he hid from the news media. And the last question that I had was, was he involved, and he said no. He said, 'Dave, I can understand your position, but you've got to understand mine. Joran's my son and I'll do everything I can to protect him.' And I believe it."
Van der Sloot's mother, Anita, has said her son told her he was on the beach with Holloway but left her there because she wanted to stay. She has maintained her son's innocence.