(CNN) -- Marathon man John Isner was knocked out in straight sets in his second round match at Wimbledon on Friday by Dutchman Thiemo de Bakker.
Less than 20 hours after finishing off Nicolas Mahut of France after 11 hours and five minutes of action and an record breaking 183 games, 23rd seed Isner had to drag his weary body on to Court Five at the All England club to face the rather fresher de Bakker.
Isner had won the final set against Mahut with an astonishing 70-68 scoreline, he lost the first set against a player ranked 30 places below him without winning a game.
The American rallied in the second set, but it was to no avail as he went down 6-0 6-3 6-2 in just one hour 14 minutes. He served a record 112 aces against Mahut but could not manage a single one against de Bakker.
Isner has also had to pull out of the doubles with compatriot Sam Querrey and knew he was in the trouble from the start.
"I have never been this exhausted before," he told gathered reporters.
"I was low on fuel out there so I do not really have a chance."
When asked about what he was doing for the next coupe of week, he joked: "Anything but tennis."
Isner is actually slated to play in a big-money exhibition match against Andy Roddick in the Dallas Cowboys stadium on July 10.
Dutch number one de Bakker had every sympathy for his opponent. "It's tough because you know he's struggling," he said. "In the second set, he was trying a little bit better, in the third also."
In other men's action on Friday, number one seed Roger Federer cruised into the third round with a straight sets victory over Arnaud Clement.
Federer took just one hour and 35 minutes to despatch his French opponent 6-2 6-4 6-2 and set up a third round meeting with Austrian Jurgen Meltzer.
Serbian third seed Novak Djokovic eased past Spain's Albert Montanes, the 28th seed, in straight sets, winning 6-1 6-4 6-4.
He will play a rejuvenated 2002 champion Lleyton Hewitt in the fourth round after the Australian dispatched Gaels Monfils of France in straight sets.
American Andy Roddick beat Philipp Kohlschreiber, of Germany, 7-5 6-7 6-3 6-3 to book a third round date with Yen Hsun Lu of Tapei.