MOSCOW, Russia (CNN) -- Russian President Dmitry Medvedev has invited U.S. Secretary of State Hillary Clinton to his private residence in suburban Barvikha for a discussion Tuesday on a broad range of issues in what one senior State Department official called a "relaxed setting."
President Obama praised Dmitry Medvedev for the "excellent working relationship" the two have developed.
Issues on the agenda for the two-hour meeting include the next steps on Iran, the Mideast conflict, cooperation on Afghanistan, possible joint work on a missile defense system, Russia's "neighborhood" and climate change.
Clinton also will meet with Foreign Minister Sergey Lavrov, following up on many of the same issues, as well as getting progress reports on the new bilateral presidential commission they jointly chair. The commission, created by presidents Medvedev and Barack Obama during the latter's July visit to Moscow, has 16 working groups dealing with a number of aspects of the relationship, from arms control to health care.
A key issue during Clinton's two-day visit to Russia will be arms control and reaching an accord to replace the 1991 Start II arms control agreement, which expires in December.
Also at the top of the agenda are Iran and international efforts to induce Tehran to end its nuclear program. A senior administration official, briefing reporters on background because of the diplomatic sensitivity of the talks, said Clinton will speak with Medvedev and Lavrov "about what specific forms of pressure Russia would be prepared to join the U.S. and other nations in."
The Obama administration has been cautiously optimistic about previous comments by Medvedev that sanctions "sometimes are inevitable." Russia traditionally opposes sanctions and Prime Minister Vladimir Putin has been highly critical of such steps. Other Russian officials have made contradictory statements on the issue.
Putin will not be in Moscow during the Clinton visit. A State Department official said he is on a previously scheduled trip to China.
During her visit, Clinton also will meet with members of Russia's civil society, including human rights leaders. She will stop by a center where Russian engineers design airplanes for U.S.-based Boeing.
She will hold a town-hall-style meeting with students at Moscow State University, attend an opera at the Bolshoi Theater and participate in the dedication of a statue to American poet Walt Whitman, one of the favorite poets of many Russians.