(CNN) -- Inter Milan's new strikers Samuel Eto'o and Diego Milito were on target again as they beat Napoli 3-1 in the San Siro on Wednesday to go top of Serie A.
Brazilian ace Lucio celebrates his third goal for Inter in the San Siro.
With previously perfect Sampdoria losing 2-0 at Fiorentina, it left the four-time defending champions on top again.
Juventus, winners of their first four games, can leapfrog them as they host Genoa on Thursday.
But fellow giants AC Milan were beaten 1-0 at Udinese, with Antonio Di Natale scoring the only goal, and are already six points adrift of arch-rivals Inter.
Eto'o seized on his chance in the box after just two minutes and Milito got behind the Napoli defense just three minutes later for the second.
Brazilian center back Lucio made it 3-0 with a header from a 32md minute corner to score for the first time since moving from Bayern Munich.
Ezequiel Lavezzi pulled one back for Napoli in the 30th, but Inter held out for a comfortable win.
In England, top two Chelsea and Manchester United both scored 1-0 wins in the League Cup, fielding below-strength teams against Queens Park Rangers and Wolves.
Fit-again Joe Cole set up Salomon Kalou for a second half winner against QPR while Danny Welbeck, assisted by Michael Owen, scored for United at Old Trafford.
Holders United played for much of the game with 10 men after Fabio Da SIlva was sent off in the first half.
Elsewhere, Tottenham, beaten by United in the final of the competition last season, thrashed Preston 5-1 with Peter Crouch getting a hat-trick.
Manchester City needed extra time to beat fellow Premier League side Fulham 2-1 at Eastlands.
In the German Cup, Cologne beat Bundesliga champions Wolfsburg 3-2, while leaders SV Hamburg were shocked by third flight Osnabrueck on penalties.
The shocks continued as Bayer Leverkusen, second in the Bundesliga, lost 2-1 to Kaiserslautern, who play in the second flight.