(CNN) -- Austrian side Rapid Vienna prolonged Aston Villa's miserable start to the season with an upset 1-0 victory in their Europa Cup first leg qualifier on Thursday night.
Aston Villa manager Martin O'Neill was left to reflect on another disappointing defeat.
Villa, who challenged for a Champions League spot for much of last season, never recovered from falling a goal behind after just a minute in the Gerhard Hanappi Stadium in Vienna.
Nikica Jelavic scored the only goal of the game and it could have been worse for Villa with Christopher Drazan having a shot cleared off the line for the dominant hosts.
Villa began their English Premier League campaign with a home defeat to Wigan on Saturday, but manager Martin O'Neill remains in bullish mood.
"They had a number of chances but we did too and could have capitalized on it," he told Press Association.
"We are still well in the game and have a great match to look forward to next week."
Villa's Premier League rivals Everton and Fulham enjoyed better fortunes in their qualifying round matches.
Everton shrugged off a 6-1 thrashing by Arsenal at the weekend and the furor surrounding defender Joleon Lescott, who was rested, to beat Sigma Olomouc 4-0 at Goodison Park.
Lescott, linked to a move to Manchester City, watched from the stands as his teammates built up a comfortable first leg advantage.
Teenager Jack Rodwell scored two fine goals and Louis Saha also notched a brace as Everton look set for the group stages of the competition.
Fulham beat Russian side Amkar Perm 3-1 at Craven Cottage with Andy Johnson scoring the opener after just three minutes.
Further goals from Clint Dempsey and Bobby Zamora put Fulham three up but the visitors hit back with a late goal and there was an injury scare for Roy Hodgson's men as striker Johnson went off with an injured shoulder and is set to be out for two months.
On a night of few shocks, Italian giants AS Roma were given a scare against Slovakian side Kosice, but a Francesco Totti double saw them claim a 3-3 away draw. Jan Novak scored twice for the hosts.
German sides enjoyed big wins with Werder Bremen hammering Aktobe of Kazakhstan 6-3 while in-form Hamburg thrashed Guingamp of France 5-1 with Croat star Mladen Petric scoring a hat-trick.
Spanish international striker David Villa scored the second goal in Valencia's 3-0 away win over Stabaek, while Primera Liga rivals Villarreal won 3-1 at Dutch side NAC Breda.